1
Yasuharu Noishiki, Kazuhiko Kodaira, Masayasu Furuse, Teruo Miyata: Method of preparing antithrombogenic medical materials. Koken, Armstrong Nikaido Marmelstein & Kubovcik, February 21, 1989: US04806595 (97 worldwide citation)

In a method of preparing an antithrombogenic medical material having a heparinized collagen as an antithrombogenic component, there is provided a method comprising the steps of fixing a protamine to a collagen through a polyepoxy compound, and heparinizing the collagen by fixing heparin to the prota ...


2
Teruo Miyata, Kazuhiko Kodaira, Masayasu Furuse, Yasuharu Noishiki: Hemostatic agent composed of collagen/gelatin and protamine. Koken, Sherman and Shalloway, June 7, 1988: US04749689 (74 worldwide citation)

This invention relates to a hemostatic agent used in surgical operations, which can be produced in two ways: one blending collagen/gelatin with protamine, the other blending collagen/gelatin with protamine and a bi-functional cross-linking agent so as to make said collagen/gelatin have a covalent bo ...


3
Eisaburo Imamura, Yasuharu Noishiki, Hitoshi Koyanagi, Teruo Miyata, Masayasu Furuse: Bioprosthetic valve. Koken, Varndell Legal Group, January 14, 1992: US05080670 (62 worldwide citation)

A bioprosthetic valve made from a biological tissue containing collagen which has been cross-linked with a polyepoxy compound is disclosed. The valve has excellent biocompatibility and is durable and is free from calcification.


4
Yasuharu Noishiki, Teruo Miyata: Medical materials. Koken, Armstrong Nikaido Marmelstein & Kubovcik, November 3, 1987: US04704131 (59 worldwide citation)

The medical material contains heparinized collagen in which heparin has been bonded to protamine covalently fixed on collagen, and, owing to its excellent compatibility with living bodies, especially, its superb antithrombotic property, can be suitably used as a substituent material for tissues or o ...


5
Teruo Miyata, Kazuhiko Kodaira, Hitoshi Higashijima, Takashi Kimura, Yasuharu Noishiki: Biomaterial comprising a composite material of a chitosan derivative and collagen derivative. Katakura Chikkarin, Koken, Wenderoth Lind & Ponack, May 26, 1992: US05116824 (57 worldwide citation)

A biomaterial excellent in biocompatibility comprising a composite material of an N-acylchitosan and collagen is described. This biomaterial is suitable for used as a wound dressing material, vascular prosthesis, artificial skin or hemostatic agent.


6
Yasuharu Noishiki: Prosthesis containing bioabsorbable materials insolubilized without chemical reagents and method of making the same. Nicem, Varndell & Varndell PLLC, November 16, 1999: US05986168 (28 worldwide citation)

The present invention relates to a prosthesis comprising one or more bioabsorbable substances insolubilized and/or immobilized in place by a physical method which excludes chemical reagents. A growth factor can be bound to the bioabsorbable substance for simulating growth of, for example, fibroblast ...


7
Koji Watanabe, Miyoshi Okamoto, Yuichi Mori, Yasuharu Noishiki: Artificial vascular graft. Toray, Wegner & Bretschneider, September 22, 1987: US04695280 (25 worldwide citation)

The present invention relates to an artificial vascular graft having ultra fine fibers smaller than 0.5 denier in fineness as part of the inner wall. The artificial vascular graft of this invention is very flexible and produces very low blood leakage. The ease of performing anastomoses is greatly im ...


8
Teruo Miyata, Yasuharu Noishiki: Medical material. Koken, Armstrong Nikaido Marmelstein & Kubovcik, September 22, 1987: US04695281 (15 worldwide citation)

The medical material according to this invention contains collagen, which as been chemically modified by saccinylation of thermal --NH.sub.2 groups of said chains attached to poly peptide chains of the collagen so that the --NH.sub.2 groups are converted into groups having --COOH groups. This succin ...


9
Yasuharu Noishiki, Teruo Miyata: Antithrombogenic medical material and method of preparing same. Koken, Armstrong Nikaido Marmelstein Kubovcik & Murray, May 23, 1989: US04833200 (11 worldwide citation)

An antithrombogenic medical material with a remarkable antithrombogenic property and histocompatibility as well as sufficient physical strength, formed by fixing a heparinized collagen to a synthetic polymer material is provided. And a method of preparing an antithrombogenic medical material is prov ...


10
Yasuharu Noishiki, Kazuhiko Kodaira, Masayasu Furuse, Teruo Miyata, Takeaki Miyamoto, Hiraku Ito: Production process of an antithrombogenic and antiadhesive material for medical use. Koken Company, Sherman and Shalloway, September 1, 1987: US04690973 (10 worldwide citation)

This invention concerns a production process of an antithrombogenic and antiadhesive material which can favorably be used as artificial blood vessels, artificial valves, grafting patches for cardiovascular organs, artificial heart catheters and so on. The gist of this invention is constructed substa ...