1
Yoshikawa Seiji, Emori Eita, Matsuura Fumiyoshi, Clark Richard, Ikuta Hironori, Yasuda Nobuyuki, Nagakura Tadashi, Yamazaki Kazuto, Aoki Mika: Xanthine derivatives as dpp-iv inhibitors. Eisai, August 27, 2003: EP1338595-A2 (68 worldwide citation)

The present invention provides novel compounds exhibiting an excellent DPPIV inhibition effect. The compounds are represented by the formula: wherein, m is 0 or 1; n is 0; R, R, R, R, R, R, R, R, R, R, R, and R each represent a hydrogen atom; X represents an alkynyl group, an aryl group, and such, w ...


2
Yoshikawa Seiji, Emori Eita, Matsuura Fumiyoshi, Richard Clark, Ikuta Hironori, Kira Kazunobu, Yasuda Nobuyuki, Nagakura Tadashi, Yamazaki Kazuto: Novel fused imidazole derivative. Eisai, March 16, 2005: EP1514552-A1 (57 worldwide citation)

The present invention is related to compounds represented by the following formula, or salts or hydrates thereof wherein, T represents a 4- to 12-membered heterocyclic group containing one or two nitrogen atoms in the ring, which is a monocyclic or bicyclic structure that may have one or more substi ...


3
Yasuda Nobuyuki, Yamazaki Kazuto: (Ja) 併用医薬, (En) Combination drug. Eisai, Yasuda Nobuyuki, Yamazaki Kazuto, SHIMIZU Hatsushi, April 8, 2004: WO/2004/028524 (56 worldwide citation)

(EN) It is intended to provide a drug comprising a combination of a dipeptidyl peptidase IV (DPPIV) inhibitor with biguanide characterized by potentiating the effect of activated glucagon-like peptide-1 (GLP-1) in blood and/or activated glucagon-like peptide-2 (GLP-2) in blood.(JA) 本発明は、血中活性型グルカゴン様ペ ...


4
Yasuda Nobuyuki, Yamazaki Kazuto: Combination drug. Eisai, July 27, 2005: EP1557165-A1 (37 worldwide citation)

The present invention provides pharmaceutical agents comprising a dipeptidyl peptidase IV (DPPIV) inhibitor and a biguanide agent in combination, which enhance the effects of active circulating glucagon-like peptide-1 (GLP-1) and/or active circulating glucagon-like peptide-2 (GLP-2).


5
Shinoda Masanobu, Emori Eita, Matsuura Fumiyoshi, Kaneko Toshihiko, Ohi Norihito, Kasai Shunji, Yoshitomi Hideki, Yamazaki Kazuto, Miyashita Sadakazu, Hibara Taro, Seiki Takashi, Clark Richard, Harada Hitoshi: Carboxylic acid derivatives and drugs containing the same. Eisai, June 26, 2002: EP1216980-A1 (25 worldwide citation)

The present invention provides a novel carboxylic acid compound, a salt thereof or a hydrate of them useful as an insulin-resistant improver, and a medicament comprising the compound as an active ingredient. That is, the present invention provides a carboxylic acid compound represented by the follow ...


6
Matsuura Fumiyoshi, Emori Eita, Shinoda Masanobu, Clark Richard, Kasai Shunji, Yoshitomi Hideki, Yamazaki Kazuto, Inoue Takashi, Miyashita Sadakazu, Hihara Taro, Harada Hitoshi, Ohashi Kaya: Carboxylic acid derivative and salt thereof. Eisai, January 14, 2004: EP1380562-A1 (14 worldwide citation)

The present invention provides a novel carboxylic acid compound, a salt thereof or a hydrate of them useful as an insulin sensitizer, and a medicament comprising the compound as an active ingredient. That is, the present invention provides a carboxylic acid compound represented by the following form ...


7
Yasuda Nobuyuki, Nagakura Tadashi, Yamazaki Kazuto, Yoshikawa Seiji, Okada Toshimi, Ikuta Hironori, Koyanagi Mika: Pharmaceutical use of n-carbamoylazole derivatives. Eisai, November 20, 2002: EP1258480-A1 (8 worldwide citation)

The present invention relates to use of 1-carbamoylazole derivatives as medicaments and pharmaceutical compositions containing 1-carbamoylazole derivatives as the active ingredient, based on their DPPIV inhibiting effects. The present invention provides a dipeptidyl peptidase IV inhibiting agent com ...


8
Yoshikawa Seiji, Emori Eita, Matsuura Fumiyoshi, Richard Clark, Ikuta Hironori, Kira Kazunobu, Yasuda Nobuyuki, Nagakura Tadashi, Yamazaki Kazuto: Novel fused imidazole derivative. Eisai, Yoshikawa Seiji, Emori Eita, Matsuura Fumiyoshi, Richard Clark, Ikuta Hironori, Kira Kazunobu, Yasuda Nobuyuki, Nagakura Tadashi, Yamazaki Kazuto, SHIMIZU Hatsushi, December 18, 2003: WO/2003/104229 (5 worldwide citation)

A compound represented by the general formula (I) [wherein T1 means an optionally substituted, monocyclic or bicyclic, 4- to 12-membered, heterocyclic group containing one or two nitrogen atoms in the ring; X means optionally substituted C1-6 alkyl, etc.; Z1 and Z2 each independently means nitrogen ...


9
Matsuura Fumiyoshi, Emori Eita, Shinoda Masanobu, Clark Richard, Kasai Shunji, Yoshitomi Hideki, Yamazaki Kazuto, Inoue Takashi, Miyashita Sadakazu, Hihara Taro: Carboxylic acid derivative and medicine comprising salt or ester of the same. Eisai, March 3, 2004: EP1394147-A1 (2 worldwide citation)

The present invention provides novel carboxylic acid derivatives useful as an insulin sensitizer, a salt thereof or a hydrate of them, and a medicament comprising the derivative as the active ingredient. Specifically, it provides a carboxylic acid derivative represented by the following formula: (wh ...


10
Matsuura Fumiyoshi, Emori Eita, Shinoda Masanobu, Clark Richard, Kasai Shunji, Yoshitomi Hideki, Yamazaki Kazuto, Inoue Takashi, Miyashita Sadakazu, Hihara Taro: Benzene compound and salt thereof. Eisai, January 2, 2004: EP1375472-A1 (2 worldwide citation)

The present invention provides a medicament comprising a benzene compound useful as an insulin sensitizer, a salt thereof or a hydrate of them and a derivative of them as the active ingredient. Specifically, it provides a benzene compound represented by the following formula, a salt thereof or a hyd ...