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Akasaka Kozo, Yonaga Masahiro, Kajiwara Akiharu, Higurashi Kunizo, Ueno Kohshi, Nagato Satoshi, Komatsu Makoto, Kitazawa Noritaka, Ueno Masataka, Yamanishi Yoshiharu, Machida Yoshimasa, Komatsu Yuki, Shimomura Naoyuki, Minami Norio, Shimizu Toshikazu, Nagaoka Atsushi: Biphenylderivatives, process for their preparation and their use as medicaments.. Eisai, October 4, 1995: EP0675118-A2 (20 worldwide citation)

A biphenyl derivative represented by the following formula (I) or a pharmacologically acceptable salt thereof: wherein R represents a hydrogen atom, a halogen atom, a hydroxyl group, an amino group, a lower alkyl group, a halogenated lower alkyl group, a lower alkoxy group, a halogenated lower alkox ...


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Sugimoto Hachiro, Yonaga Masahiro, Karibe Norio, Iimura Youichi, Nagato Satoshi, Sasaki Atsushi, Yamanishi Yoshiharu, Ogura Hiroo, Kosasa Takashi, Uchikoshi Kumi, Yamatsu Kiyomi: Cyclic amide derivatives.. Eisai, January 29, 1992: EP0468187-A2 (18 worldwide citation)

The cyclic amide derivative is defined by the formula (I) or a salt thereof: R1-(CH2)n-Z in which R1 is a group derived from a cyclic amide compound, substituted or unsubstituted, n is zero or an integer of 1 to 10 and Z is R2 being an aryl, a substituted aryl, a cycloalkyl or a heterocyclic group, ...


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Sugimoto Hachiro, Tsuchiya Yutaka, Higurashi Kunizou, Karibe Norio, Iimura Youichi, Sasaki Atsushi, Yamanishi Yoshiharu, Ogura Hiroo, Araki Shin, Kosasa Takashi, Kusota Atsuhiko, Kososa Michiko, Yamatsu Kiyomi: 2-(indan-1-one-2-yl-alkyl)-1-phenylalkyl-piperidines and processes for their preparation. Eisai, November 13, 1996: EP0742207-A1 (18 worldwide citation)

Processes are provided for preparing cyclic amine compounds defined within the formula: in which J is indanyl, indanonyl, indenyl, indenonyl, indanedionyl, tetralonyl, benzosuberonyl, indanolyl or a divalent group thereof, K is phenyl, an arylalkyl or cynnamyl, B is -(CHR22)r-, R22 being H or methyl ...


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Abu Shakra Susan, Gray Julian A, Yamanishi Yoshiharu, Nobuyuki Mori: Dihydropyridine compounds and compositions for headaches. Eisai, Abu Shakra Susan, Gray Julian A, Yamanishi Yoshiharu, Nobuyuki Mori, GRIEFF Edward D, October 12, 2006: WO/2006/107860 (18 worldwide citation)

The invention provides methods for treating and/or preventing headaches by administering to patients therapeutically effective amounts of 1 ,2-dihydropyridine compounds, and, optionally, cholinesterase inhibitors and/or anti-migraine agents. The headaches may be primary headaches, such as migraines, ...


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Sugimoto Hachiro, Tsuchiya Yutaka, Higurashi Kunizou, Karibe Norio, Iimura Youichi, Sasaki Atsushi, Yamanishi Yoshiharu, Ogura Hiroo, Araki Shin, Kosasa Takashi, Kusota Atsuhiko, Kozasa Michiko, Yamatsu Kiyomi: 4-[2-indanyl-1-one]alkylpiperidines as anticholinergic agents.. Eisai, September 27, 1995: EP0673927-A1 (17 worldwide citation)

A cyclic amine compound is defined by the formula: in which J is indanyl, indanonyl, indenyl, indenonyl, indanedionyl, tetralonyl, benzosuberonyl, indanolyl or a divalent group thereof, K is phenyl, an arylalkyl or cynnamyl, B is -(CHR22)r-, R22 being H or methyl, -CO-(CHR22)r-, =(CH-CH=CH)b-, =CH-( ...


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Sugimoto Hachiro, Tsuchiya Yutaka, Higurashi Kunizou, Karibe Norio, Iimura Youichi, Sasaki Atsushi, Yamanishi Yoshiharu, Ogura Hiroo, Araki Shin, Kosasa Takashi, Kusota Atsuhiko, Kozasa Michiko, Yamatsu Kiyomi: 1,4-substituted piperidines as acetylchozinesterase inhibitors and their use for the treatment of alzheimers disease.. Eisai, January 19, 1994: EP0579263-A1 (10 worldwide citation)

Cyclic amines of formula (I) and their salts are new. J = phenyl, pyridyl, pyrazyl, quinolyl, cyclohexyl, quinoxalyl or furyl (all opt. substd.), a monovalent gp. derived from a cyclic amide cpd., lower alkyl, or -CH=CH-R21; R21 = H or lower alkoxycarbonyl; B = (CHR22)r, CO(CHR22)r, NR4-(CHR22)r, CO ...


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Tsuchiya Yutaka, Sasaki Atsushi, Yoshino Hiroshi, Karibe Norio, Sugimoto Hachiro, Kubota Atsuhiko, Kosasa Michiko, Araki Shin, Ikeda Masuhiro, Yamanishi Yoshiharu, Machida Ryoichi, Yamatsu Kiyomi: Polypeptides, methods for their preparation, pharmaceutical compositions comprising them and use.. Eisai, September 20, 1989: EP0333071-A2 (10 worldwide citation)

A polypeptide is shown with the following formula: A-B-C-D-E-F-R wherein A, B, C, D, E, F and R are as defined in claim 1. The invention includes pharmaceutical compositions comprising the above polypeptide and the use of this polypeptide. Finally, preparation methods for the new polypeptide are dis ...


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Sugitomo Hachiro, Tsuchiya Yutaka, Higurashi Kunizou, Karibe Norio, Iimura Youichi, Sasaki Atsushi, Yamanishi Yoshiharu, Ogura Hiroo, Araki Shin, Kosasa Takashi, Kusota Atsuhiko, Kosasa Michiko, Yamatsu Kiyomi: Piperidine and piperazine compounds for use in the treatment of alzheimer. Eisai, July 18, 2001: EP1116716-A1 (5 worldwide citation)

A cyclic amine compound or a salt thereof is defined by the formula: in which J is (a) an optionally substituted group selected from (1) phenyl, (2) pyridyl, (3) pyrazyl, (4) quinolyl, (5) cyclohexyl, (6) quinoxalyl and (7) furyl; (b) a monovalent or divalent group, in which the phenyl may have a su ...


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Iimura Yoichi, Kosasa Takashi, Yamanishi Yoshiharu, Sugimoto Hachiro, Takeuchi Yoshio, Shibata Tetsuo, Suzuki Eimiko: Fluorides of 4-substituted piperidine derivatives. Eisai, November 28, 2001: EP1157989-A1 (5 worldwide citation)

The present invention provides a novel compound having an excellent acetylcholinesterase inhibitory effect. That is, it provides a 4-substituted piperidine compound fluoride represented by the following formula, a pharmaceutically acceptable salt thereof or hydrates thereof (provided that 1-benzyl-4 ...