1
Kimura Teiji, Watanabe Nobuhisa, Takase Yasutaka, Hayashi Kenji, Matsui Makoto, Ikuta Hironori, Yamagishi Youji, Akasaka Kozo, Tanaka Hiroshi, Ohtsuka Issei, Saeki Takao, Kogushi Motoji, Fujimori Tohru, Saito Isao: Benzene, pyridine and pyrimidine derivative.. Eisai, April 1, 1992: EP0477778-A2 (24 worldwide citation)

A benzene, pyridine or pyrimidine derivative having the below shown formula is novle and useful as an anti-arteriosclerotic agent. wherein R stands for a lower alkyl group, an amino group which may be substituted, or the like; R stands for a group represented by the formula: (wherein R stands for an ...


2
Ikuta Hironori, Yamagishi Youji, Akasaka Kozo, Yamatsu Isao, Kobayashi Seiichi, Shirota Hiroshi, Katayama Kouichi: 2-pyrrolidone derivatives, process for preparing them, pharmaceutical composition and use.. Eisai, December 17, 1986: EP0204964-A1 (14 worldwide citation)

Disclosed is a novel 2-pyrrolidone derivative, including 3-(3,5-di-tert-butyl-4-hydroxy-benzylidene)-2-pyrrolidone and an N-substituted one. The substituent includes alkyl, alkoxy, alkynyl, phenyl-alkylene, hydroxy-alkylene and amino-alkylene. It is effective as an anti-inflammatory, analgesic and a ...


3
Yamagishi Youji, Akasaka Kozo, Suzuki Takeshi, Miyamoto Mitsuaki, Nakamoto Kouji, Okano Kazuo, Abe Shinya, Ikuta Hironori, Hayashi Kenji, Yoshimura Hiroyuki, Fujimori Tohru, Harada Koukichi, Yamatsu Isao: Diphenyl-methane derivative, pharmaceutical composition and use.. Eisai, September 30, 1987: EP0238973-A2 (2 worldwide citation)

A new diphenyl-methane derivative is useful to inhibit agglomeration of blood and is defined by the formula, including a diphenylethylene derivative and a benzophenone oxime ether derivative. in which R1 and R2 each are hydrogen, hydroxyl or a lower alkoxy, U is =CXY or =N-O-W, X is hydrogen, cyano ...


4
Yamagishi Youji, Akasaka Kozo, Suzuki Takeshi, Miyamoto Mitsuaki, Nakamoto Kouji, Okano Kazuo, Abe Shinya, Ikuta Hironori, Hayashi Kenji, Yoshimura Hiroyuki, Fujimori Tohru, Harada Koukichi, Yamatsu Isao: Diphenyl-methane derivative, pharmaceutical composition and use.. Eisai, December 20, 1989: EP0346943-A1 (2 worldwide citation)

A new diphenyl-methane derivative is useful to inhibit agglomeration of blood and is defined by the formula, including a diphenylethylene derivative and a benzophenone oxime ether derivative. in which R1 and R2 each are hydrogen, hydroxyl or a lower alkoxy, W is -CH2-CO-CH2-COOR13, R13 being hydroge ...


5
Yamagishi Youji, Akasaka Kozo, Suzuki Takeshi, Miyamoto Mitsuaki, Nakamoto Kouji, Okano Kazuo, Abe Shinya, Ikuta Hironori, Hayashi Kenji, Yoshimura Hiroyuki, Fujimori Tohru, Harada Koukichi, Yamatsu Isao: Benzophenone oxime derivatives, pharmaceutical compositions and use.. Eisai, April 1, 1992: EP0478001-A1 (1 worldwide citation)

Diphenyl-methane derivs. of formula (I) are new, (where R1 and R2 each = H, OH or lower alkoxy; U = -CXY or =N-O-W; X = H, CN or -COR6; R6 = OH or NH2; Y = -R10-COOR3, -CONR4R5, -CH2NHSO2-C6H5 or -C(R8)=NR7; R3 = H or lower alkoxy; R10 = opt. branched 1-3C alkylene; R4 and R5 each = H, lower alkyl o ...


6
Kimura Teiji, Watanabe Nobuhisa, Takase Yasutaka, Hayashi Kenji, Matsui Makoto, Ikuta Hironori, Yamagishi Youji, Akasaka Kozo, Tanaka Hiroshi, Ohtsuka Issei, Saeki Takao, Kogushi Motoji, Fujimori Tohru, Saito Isao: Benzene, pyridine and pyrimidine derivative.. Eisai, September 21, 1994: EP0615970-A1

A benzene, pyridine or pyrimidine derivative having the below shown formula is novle and useful as an anti-arteriosclerotic agent. wherein R stands for a lower alkyl group, an amino group which may be substituted, or the like; R stands for a group represented by the formula: (wherein R stands for an ...


7
Yamagishi Youji, Akasaka Kozo, Suzuki Takeshi, Miyamato Mitsuaki, Nakamoto Kouji, Okano Kazuo, Abe Shinya, Ikuta Hironori, Hayashi Kenji, Yoshimura Hiroyuki, Fujimori Tohru, Harada Koukichi, Yamatsu Isao: Diphenyl-methane derivative, pharmaceutical composition and use.. Eisai, April 8, 1992: EP0479332-A2

A new diphenyl-methane derivative is useful to inhibit agglomeration of blood and is defined by the formula, including a diphenylethylene derivative and a benzophenone oxime ether derivative. in which R1 and R2 each are hydrogen, hydroxyl or a lower alkoxy, U is =CXY or =N-O-W, X is hydrogen, cyano ...


8
Yamagishi Youji, Hamamura Kimio, Akasaka Kozo: Produits intermediaires pour la synthese disomeres optiquement actifs du d-o-tocopherol, Intermediate for the synthesis of optically active d- o tocopherol. Yamagishi Youji, Hamamura Kimio, Akasaka Kozo, Eisai, SMART & BIGGAR, April 25, 1990: CA1268188

ABSTRACT OF THE DISCLOSUREOptically active alpha-tocopherol is synthesized by a multi-step process using phytol as a starting material and the novelintermediate of the present invention. The overall process doesnot require an optical resolution step.


9
Ikuta Hironori, Yamagishi Youji, Yamatsu Isao, Akasaka Kozo, Kobayashi Seiichi, Katayama Kouichi, Shirota Hiroshi: Derives intermediaires 2-pyrrolidone et leur procede de production, Intermediate 2-pyrrolidone derivatives and their production process. Ikuta Hironori, Yamagishi Youji, Yamatsu Isao, Akasaka Kozo, Kobayashi Seiichi, Katayama Kouichi, Shirota Hiroshi, Eisai, SMART & BIGGAR, July 10, 1990: CA1271482

ABSTRACT OF THE DISCLOSURE Disclosed are novel 2-pyrrolidone derivatives (VII): Imageuseful for the production of compounds (I) Image (I) (wherein W represents halogen; and R represents a hydrogen atom,a lower alkyl, a lower alkoxy or a lower alkynyl group or a groupof the formula: -(CH2)n-X (VIII)w ...


10
Akasaka Kozo, Hamamura Kimio, Yamagishi Youji: Intermediaire pour la synthese de d-.alpha.-tocopherol, Intermediate for the synthesis of optically active d- .alpha. tocopherol. Eisai, SMART & BIGGAR, July 26, 1988: CA1239647

ABSTRACT OF THE DISCLOSURE Optically active alpha-tocopherol is synthesized by a multi-step process using phytol as a starting material and the novelintermediate of the present invention. The overall process doesnot require an optical resolution step.