1
Qun Sun, Xiaoming Zhou, Donald J Kyle: Aryl substituted benzimidazoles and their use as sodium channel blockers. Euro Celtique, Sterne Kessler Goldstein & Fox P L L C, April 4, 2006: US07022714 (18 worldwide citation)

This invention relates aryl substituted benzimidazoles of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein R1, R2, R10 and n are defined in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage ...


2
Xiaoming Zhou, Roger Hoover, Sergey Shekyan, Justin Call: Intercepting and supervising calls to transformed operations and objects. Shape Security, Hickman Palermo Truong Becker Bingham Wong, February 10, 2015: US08954583 (17 worldwide citation)

In an embodiment, a method comprises intercepting a first set of instructions from a server computer that define one or more objects and one or more original operations that are based, at least in part, on the one or more objects; modifying the first set of instructions by adding one or more supervi ...


3
Justin D Call, Subramanian Varadarajan, Xiaochan Huang, Xiaoming Zhou, Marc R Hansen: Detecting the introduction of alien content. J Johnson, March 28, 2017: US09609006 (12 worldwide citation)

A computer-implemented method for identifying abnormal computer behavior includes receiving, at a computer server subsystem, data that characterizes subsets of particular document object models for web pages rendered by particular client computers; identifying clusters from the data that characteriz ...


4
Justin D Call, Subramanian Varadarajan, Xiaohan Huang, Xiaoming Zhou, Marc R Hansen: Detecting the introduction of alien content. Shape Security, Fish & Richardson P C, December 29, 2015: US09225737 (12 worldwide citation)

A computer-implemented method for identifying abnormal computer behavior includes receiving, at a computer server subsystem, data that characterizes subsets of particular document object models for web pages rendered by particular client computers; identifying clusters from the data that characteriz ...


5
Donald J Kyle, Qun Sun, Laykea Tafesse, Chongwu Zhang, Xiaoming Zhou: Therapeutic agents useful for treating pain. Euro Celtique, Jones Day, October 9, 2007: US07279493 (12 worldwide citation)

A compound of formula: wherein A, Ar, R3, R6, and m are disclosed herein, or a pharmaceutically acceptable salt thereof (a “Cyanoiminopiperazine Compound”), compositions comprising an effective amount of a Cyanoiminopiperazine Compound, and methods for treating or preventing pain, urinary incontinen ...


6
Qun Sun, Kate Xin Wen, Xiaoming Zhou: Therapeutic agents useful for treating pain. Dechert, August 11, 2009: US07572812 (11 worldwide citation)

Piperidine Compounds; compositions comprising a Piperidine Compound; and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory de ...


7
Qun Sun, Xiaoming Zhou: Therapeutic agents useful for treating pain. Euro Celtique, Jones Day, January 2, 2007: US07157462 (11 worldwide citation)

A compound of formula: wherein Ar, Ar1, Ar2, R3–R6, R13, m, and t are disclosed herein, or a pharmaceutically acceptable salt thereof (a “Hydroxyiminopiperazine Compound”); compositions comprising an effective amount of a Hydroxyiminopiperazine Compound; and methods for treating or preventing pain a ...


8
Qun Sun, Xiaoming Zhou: Therapeutic agents useful for treating pain. Purdue Pharma, Dechert, June 15, 2010: US07737148 (8 worldwide citation)

A compound of formula: wherein Ar, Ar1, Ar2, R3-R6, R13, m, and t are disclosed herein, or a pharmaceutically acceptable salt thereof (a “Hydroxyiminopiperazine Compound”); compositions comprising an effective amount of a Hydroxyiminopiperazine Compound; and methods for treating or preventing pain a ...


9
Donald J Kyle, Laykea Tafesse, Xiaoming Zhou: 7,8-cyclicmorphinan analogs. Purdue Pharma, Sterne Kessler Goldstein & Fox P L L C, February 17, 2015: US08957084 (8 worldwide citation)

The application is directed to compounds of Formula I-A and pharmaceutically acceptable salts and solvates thereof, wherein Cy, R1a-R3a, R4a, and R4b are defined as set forth in the specification. The invention is also directed to use of compounds of Formula I-A to treat disorders responsive to the ...


10
Parviz Gharagozloo, Khondaker Islam, Donald J Kyle, Qun Sun, Laykea Tafesse, John William Frank Whitehead, Ji Yang, Xiaoming Zhou: Therapeutic agents useful for treating pain. Euro Celtique, Jones Day, March 8, 2005: US06864261 (8 worldwide citation)

A compound of formula (wherein A, R1, R2, R6, m and n are disclosed herein) or a pharmaceutically acceptable salt thereof (a “Piperazine Compound”); pharmaceutical compositions comprising a Piperazine Compound; and methods for treating pain, urinary incontinence (UI), an addictive disorder, Parkinso ...