1
Guoqing Chen, Jeffrey Adams, Jean Bemis, Shon Booker, Guolin Cai, Lucian Di Pietro, Celia Dominguez, Daniel Elbaum, Julie Germain, Stephanie Geuns Meyer, Michael Handley, Qi Huang, Joseph L Kim, Tae Seong Kim, Alexander Kiselyov, Xiaohu Ouyang, Vinod F Patel, Leon M Smith, Markian Stec, Andrew Tasker, Ning Xi, Shimin Xu, Chester Chenguang Yuan, Michael Croghan: Substituted alkylamine derivatives and methods of use. Amgen, Joseph W Bulock, February 7, 2006: US06995162 (13 worldwide citation)

Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis a ...


2
Guoqing Chen, Jeffrey Adams, Jean Bemis, Lucian Di Pietro, Celia Dominguez, Daniel Elbaum, Julie Germain, Qi Huang, Joseph L Kim, Xiaohu Ouyang, Vinod F Patel, Leon M Smith, Andrew Tasker, Ning Xi, Shimin Xu, Chester Chenguang Yuan, Michael Croghan, Tae Seong Kim: Substituted amine derivatives and methods of use. Amgen, Joseph W Bulock, September 12, 2006: US07105682 (10 worldwide citation)

Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseas ...


3
Guoqing Chen, Jeffrey Adams, Jean Bemis, Lucian Di Pietro, Celia Dominguez, Daniel Elbaum, Julie Germain, Qi Huang, Joseph L Kim, Xiaohu Ouyang, Vinod F Patel, Leon M Smith, Andrew Tasker, Ning Xi, Shimin Xu, Chester Chenguang Yuan, Michael Croghan, Tae Seong Kim: Substituted amine derivatives and methods of use. Amgen, Joseph W Bulock, April 7, 2009: US07514564 (6 worldwide citation)

Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseas ...


4
Guoqing Chen, Jeffrey A Adams, Jean E Bemis, Shon Booker, Guolin Cai, Lucian V DiPietro, Celia Dominguez, Daniel Elbaum, Julie Germain, Stephanie Geuns Meyer, Michael K Handley, Qi Huang, Joseph L Kim, Tae Seong Kim, Alexander S Kiselyov, Xiaohu Ouyang, Vinod F Patel, Leon M Smith, Markian M Stec, Andrew Tasker, Ning Xi, Shimin Xu, Chester Chenguang Yuan, Michael D Croghan: Substituted alkylamine derivatives and methods of use. Amgen, Finnegan Henderson Farabow Garrett & Dunner, February 4, 2014: US08642624

Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis a ...


5
Daria Mochly Rosen, Che Hong Chen, Xiaohu Ouyang: Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof. The Board of Trustees—Leland Stanford Junior University, Rudy J Ng, Paula A Borden, Bozicevic Field & Francis, April 19, 2016: US09315484

The present invention provides compounds that function as modulators of mitochondrial aldehyde dehydrogenase-2 (ALDH2) activity; and pharmaceutical compositions comprising the compounds. The present invention provides therapeutic methods involving administering a subject compound, or a subject pharm ...


6
Daria Mochly Rosen, Che Hong Chen, Xiaohu Ouyang: Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof. The Board of Trustees—Leland Stanford Junior University, Rudy J Ng, Paula A Borden, Bozicevic Field & Francis, March 1, 2016: US09273025

The present invention provides compounds that function as modulators of mitochondrial aldehyde dehydrogenase-2 (ALDH2) activity; and pharmaceutical compositions comprising the compounds. The present invention provides therapeutic methods involving administering a subject compound, or a subject pharm ...


7
Daria Mochly Rosen, Che Hong Chen, Xiaohu Ouyang: Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof. The Board of Trustees Leland Stanford Junior University, Rudy J Ng, Paula A Borden, Bozicevic Field & Francis, August 11, 2015: US09102651

The present invention provides compounds that function as modulators of mitochondrial aldehyde dehydrogenase-2 (ALDH2) activity; and pharmaceutical compositions comprising the compounds. The present invention provides therapeutic methods involving administering a subject compound, or a subject pharm ...


8
James K Chen, Surajit Sinha, Ilya Shestopalov, Xiaohu Ouyang: Photocleavable linker methods and compositions. The Board of Trustees of the Leland Stanford Junior University, Bozicevic Field & Francis, Pamela J Sherwood, April 12, 2011: US07923562

Bifunctional linkers are provided that comprise a photocleavable moiety flanked by two different amine reactive moieties. In some embodiments the photocleavable moiety is a dimethoxynitrobenzyl moiety. In other embodiments the photocleavable moiety is 8-bromo-7-hydroxyquinoline. In other embodiments ...


9
Guoqing Chen, Jeffrey Adams, Jean Bemis, Lucian Di Pietro, Celia Dominguez, Daniel Elbaum, Julie Germain, Qi Huang, Joseph L Kim, Xiaohu Ouyang, Vinod F Patel, Leon M Smith, Andrew Tasker, Ning Xi, Shimin Xu, Chester Chenguang Yuan, Michael Croghan, Tae Seong Kim: Substituted amine derivatives and methods of use. Amgen Incorporated, October 16, 2003: US20030195230-A1

Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseas ...


10
Xiaoling Chen, Hai Ying He, Joel Kawakami, Alexander Kiselyov, Xiaohu Ouyang, Vatee Pattaropong, Evgueni Piatnitski, Maria Carolina Tuma, John Kincaid: Heterocyclic compounds and their use as anticancer agents. Imclone Systems Incorporated, Imclon, Lerner David Littenberg Krumholz & Mentlik, February 19, 2009: US20090048301-A1

The present invention relates to heterocyclic compounds that have anticancer activity, and pharmaceutical compositions that contain such compounds, methods of treating diseases and conditions in mammals using such compounds and composition and methods for their manufacture.