1
Toufike Kanouni
Qing Dong, Xianchang Gong, Stephen W Kaldor, Toufike Kanouni, Nicholas Scorah, Michael B Wallace, Feng Zhou: MAPK/ERK KINASE INHIBITORS. TAKEDA PHARMACEUTICAL COMPANY, TAKEDA SAN DIEGO, May 27, 2010: US20100130518-A1

Compounds of the following formula are provided for use with MEK (I): wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of usin ...


2
Toufike Kanouni
Qing Dong, Xianchang Gong, Stephen W Kaldor, Toufike Kanouni, Nicholas Scorah, Michael B Wallace, Feng Zhou: Mapk/erk kinase inhibitors. Takeda San Diego, October 16, 2008: US20080255160-A1

Compounds of the following formula are provided for use with MEK: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using sa ...


3
Wolfgang Wrasidlo, John Doukas, Ivor Royston, Glenn Noronha, John D Hood, Elena Dneprovskaia, Xianchang Gong, Ute Splittgerber, Ningning Zhao: Vasculostatic agents and methods of use thereof. TargeGen, DLA Piper US, April 24, 2007: US07208493 (36 worldwide citation)

Compositions and methods and are provided for treating disorders associated with compromised vasculostasis. Invention methods and compositions are useful for treating a variety of disorders including for example, stroke, myocardial infarction, cancer, ischemia/reperfusion injury, autoimmune diseases ...


4
Glenn Noronha, Kathy Barrett, Jianguo Cao, Colleen Gritzen, Xianchang Gong, John D Hood, Chi Ching Mak, Andrew McPherson, Ved Prakash Pathak, Joel Renick, Richard M Soll, Ute Splittgerber, Wolfgang Wrasidlo, Binqi Zeng, Ningning Zhao, Elena Dneprovskaia: Benzotriazine inhibitors of kinases. TargeGen, Goodwin Procter, November 25, 2008: US07456176 (4 worldwide citation)

The invention provides benzotriazine compounds having formula (I). The benzotriazine compounds of the invention are capable of inhibiting kinases, such members of the Src kinase family, and various other specific receptor and non-receptor kinases.


5
Xianchang Gong, Kathy Barrett, Jianguo Cao, Colleen Gritzen, Glenn Noronha, John D Hood, Chi Ching Mak, Andrew McPherson, Ved Prakash Pathak, Joel Renick, Richard M Soll, Ute Splittgerber, Wolfgang Wrasidlo, Binqi Zeng, Ningning Zhao, Elena Dneprovskaia: Benzotriazine inhibitors of kinases. TargeGen, Morrison & Foerster, July 9, 2013: US08481536

The invention provides benzotriazine compounds having formula (I). The benzotriazine compounds of the invention are capable of inhibiting kinases, such members of the Src kinase family, and various other specific receptor and non-receptor kinases.


6
Wolfgang Wrasidlo, John Doukas, Ivor Royston, Glenn Noronha, John D Hood, Elena Dneprovskaia, Xianchang Gong, Ute Splittgerber, Ningning Zhao: Vasculostatic agents and methods of use thereof. TargeGen, Gray Cary Ware & Freidenrich, August 26, 2004: US20040167198-A1

Compositions and methods and are provided for treating disorders associated with compromised vasculostasis. Invention methods and compositions are useful for treating a variety of disorders including for example, stroke, myocardial infarction, cancer, ischemia/reperfusion injury, autoimmune diseases ...


7
Xianchang Gong: Nanoparticles of cyclic tetrapyrrolic compounds as gene and drug delivery carriers. Xianchang Gong, April 22, 2004: US20040076585-A1

The present invention relates to a method using nanoparticles of cyclic tetrapyrrolic compounds as gene and drug delivery agents. Pharmaceutical agents can be packed or condensed inside nanoparticles of cyclic tetrapyrrolic compounds and delivered to cells. In vitro experiments showed nanoparticles ...


8
Jason W Brown, Sanjib Das, Qing Dong, Xianchang Gong, Stephen W Kaldor, Yan Liu, Bheema R Paraselli, Nicholas Scorah, Jeffrey A Stafford, Michael B Wallace: Kinase inhibitors. Takeda San Diego, May 24, 2007: US20070117816-A1

Compounds, pharmaceutical compositions, kits and methods are provided for use with kinases that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.


9
Wolfgang Wrasidlo, John Doukas, Ivor Royston, Glenn Noronha, John D Hood, Elena Dneprovskaia, Xianchang Gong, Ute Splittgerber, Ningning Zhao: Vasculostatic agents and methods of use thereof. Targegen, Lisa A Haile JD PhD, Dla Piper Us, September 6, 2007: US20070208019-A1

Compositions and methods and are provided for treating disorders associated with compromised vasculostasis. Invention methods and compositions are useful for treating a variety of disorders including for example, stroke, myocardial infarction, cancer, ischemia/reperfusion injury, autoimmune diseases ...


10
Xianchang Gong: Method to prepare porphyrin nanoparticles and its application as oxidation catalyst. Kava Technology, December 18, 2003: US20030232982-A1

The present invention relates to a method to prepare porphyrin nanoparticles and its application as oxidation catalyst. Mixing solvent techniques was used to prepare porphyrin nanoparticles. The sizes of the resulted porphyin nanoparticles are in the range of 1-1000 nm. The resulted porphyrin nanopa ...