1
Patchett Arthur A, Harris Elbert E, Wyvratt Matthew J, Tristram Edward W: Carboxyalkyl dipeptide derivatives, process for preparing them and pharmaceutical composition containing them.. Merck & Co, June 25, 1980: EP0012401-A1 (181 worldwide citation)

Carboxyalkyl dipeptide derivatives and related compounds which are useful as antihypertensives, and having the formulae: wherein R and R are the same or different and are hydroxy, alkoxy, alkenoxy, dialkylamino alkoxy, acylamino alkoxy, acyloxy alkoxy, aryloxy, alkyloxy, substituted aryloxy or subst ...


2
Beattie Thomas R, Fischer Michael H, Ok Hyun O, Wyvratt Matthew J: Aminomacrolides and derivatives having immunosuppressive activity.. Merck & Co, May 22, 1991: EP0428365-A1 (31 worldwide citation)

Aminomacrolides of the general structural Formula I: have been prepared from suitable precursors by incorporation of a nitrogen substituent at C-3 sec and/or C-4 sec of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, in ...


3

4
Beattie Thomas R, Wyvratt Matthew J, Dumont Francis J: Antagonists of immunosuppressive macrolides.. Merck & Co, January 2, 1992: EP0463690-A1 (17 worldwide citation)

Hydroxymacrolides and derivatives of the general structural Formula I: wherein: Z is (OR, H) or oxo; R is hydrogen, C1-C6 alkanoyl, aryl C1-C6 alkanoyl or aroyl; have been prepared from suitable precursors by oxidation at C-20. These macrolides are useful as antagonists of FK-506-type immunosuppress ...


5
Goulet Mark, Ashton Wallace T, Chu Lin, Fisher Michael H, Girotra Narindar N, Lin Peter, Wyvratt Matthew J: Antagonists of gonadotropin releasing hormone. Merck & Co, October 28, 1998: EP0873336-A1 (8 worldwide citation)

There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.


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Sinclair Peter J, Goulet Mark, Wong Frederick, Parsons William H, Goulet Joung, Wyvratt Matthew J: O-heteroaryl, o-alkylheteroaryl, o-alkenylheteroaryl and o-alkynylheteroaryl macrolides.. Merck & Co, March 17, 1993: EP0532088-A1 (7 worldwide citation)

O-Heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides of the general structural Formula I: have been prepared from suitable precursors by alkylation and/or arylation at C-3'' and/or C-4'' of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mamm ...


7
Wyvratt Matthew J, Biftu Tesfaye, Fisher Michael H, Schmatz Dennis M: Antiprotozoal imidazopyridine compounds. Merck & Co, Wyvratt Matthew J, Biftu Tesfaye, Fisher Michael H, Schmatz Dennis M, MERCK 126 East Lincoln Avenue Rahway NJ 07065 0907, September 23, 2004: WO/2004/080390 (7 worldwide citation)

Compounds described by the Formula (I): (I) or pharmaceutically acceptable salts, or N-oxides thereof. The compounds are useful for the treatment and prevention of protozoal diseases in mammals and birds. A method for controlling coccidiosis in poultry comprises administering an effective amount of ...


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Biftu Tesfaye, Fisher Michael H, Wyvratt Matthew J: Antiprotozoal imidazopyridine compounds. Merck & Co, Biftu Tesfaye, Fisher Michael H, Wyvratt Matthew J, MERCK 126 East Lincoln Avenue Rahway NJ 07065 0907, July 7, 2005: WO/2005/060571 (7 worldwide citation)

Compounds described by the Formula (I) or (II): or pharmaceutically acceptable salts, or N-oxides thereof. The compounds are useful for the treatment and prevention of protozoal diseases in mammals and birds. A method for controlling coccidiosis in poultry comprises administering an effective amount ...


9
Goulet Mark, Ashton Wallace T, Chu Lin, Fisher Michael H, Girotra Narindar N, Lin Peter, Wyvratt Matthew J: Antagonist of gonadotropin releasing hormone. Merck &Amp Co, April 17, 2001: JP2001-106685 (6 worldwide citation)

PROBLEM TO BE SOLVED: To obtain a medicinal composition containing a compound of formula (I) or pharmaceutically acceptable salt thereof which is useful as an antagonist of GnRH and may be useful for treatment of a variety of sex-hormone related and other conditions in men and women. SOLUTION: This ...


10
Goulet Mark, Wyvratt Matthew J, Sinclair Peter J, Wong Frederick: O-aryl, o-alkyl, o-alkenyl and o-alkynylmacrolides having immunosuppressive activity.. Merck & Co, November 25, 1992: EP0515071-A2 (5 worldwide citation)

O-Aryl, O-alkyl, O-alkenyl and O-alkynylmacrolides of the general structural Formula I: have been prepared from suitable precursors by alkylation and/or arylation at C-3 sec and/or C-4 sec of the cyclohexyl ring, and have inter alia immunosuppressive activity.