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Blizzard Timothy A, Chen Helen, Gude Candido, Hermes Jeffrey D, Imbriglio Jason E, Kim Seongkon, Wu Jane Y, Ha Sookhee, Mortko Christopher J, Mangion Ian, Rivera Nelo, Ruck Rebecca T, Shevlin Michael: Beta-lactamase inhibitors. Merck & Co, Blizzard Timothy A, Chen Helen, Gude Candido, Hermes Jeffrey D, Imbriglio Jason E, Kim Seongkon, Wu Jane Y, Ha Sookhee, Mortko Christopher J, Mangion Ian, Rivera Nelo, Ruck Rebecca T, Shevlin Michael, MERCK 126 East Lincoln Avenue Rahway New Jersey 07065 0907, July 23, 2009: WO/2009/091856 (32 worldwide citation)

Substituted bicyclic beta-lactams of Formula I: (I), are ß-lactamase inhibitors, wherein a, X, R1 and R2 are defined herein. The compounds and pharmaceutically acceptable salts thereof are useful in the treatment of bacterial infections in combination with ß-lactam antibiotics. In particular, the co ...


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BLIZZARD TIMOTHY A, CHEN HELEN, GUDE CANDIDO, HERMES JEFFREY D, IMBRIGLIO JASON E, KIM SEONGKON, WU JANE Y, HA SOOKHEE, MORTKO CHRISTOPHER J, MANGION IAN, RIVERA NELO, RUCK REBECCA T, SHEVLIN MICHAEL: [fr] Inhibiteurs de bêta-lactamase, [de] Beta-Lactamase-Hemmer, [en] Beta-lactamase Inhibitors. MERCK SHARP & DOHME, November 27, 2013: EP2666774-A1

[en] Substituted bicyclic beta-lactams of Formula I: are -lactamase inhibitors, wherein a , X, R 1 and R 2 are defined herein. The compounds and pharmaceutically acceptable salts thereof are useful in the treatment of bacterial infections in combination with -lactam antibiotics. In particular, the c ...


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Dininno Frank P, Chen Helen Y, Kim Seongkon, Wu Jane Y: Estrogen receptor modulators. Merck & Co, August 13, 2003: EP1333827-A2

The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to es ...


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Dininno Frank P, Kim Seongkon, Wu Jane Y: Estrogen receptor modulators. Merck & Co, July 23, 2003: EP1328522-A2

The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to es ...


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Dininno Frank P, Kim Seongkon, Wu Jane Y: Estrogen receptor modulators. Merck & Co, Dininno Frank P, Kim Seongkon, Wu Jane Y, MERCK 126 East Lincoln AvenueRahway NJ 07065 0907, April 25, 2002: WO/2002/032373

The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to es ...


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Dininno Frank P, Chen Helen Y, Kim Seongkon, Wu Jane Y: Estrogen receptor modulators. Merck & Co, Dininno Frank P, Chen Helen Y, Kim Seongkon, Wu Jane Y, MERCK 126 East Lincoln AvenueRahway NJ 07065 0907, April 25, 2002: WO/2002/032377

The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to es ...


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Dininno Frank P, Wu Jane Y, Kim Seongkon, Chen Helen Y: Estrogen receptor modulators. Merck & Co, Dininno Frank P, Wu Jane Y, Kim Seongkon, Chen Helen Y, MERCK 126 East Lincoln Avenue Rahway NJ 07065 0907, October 23, 2003: WO/2003/086388

The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to es ...