James E Brown, Wouter E Roorda: Directional drug delivery stent and method of use. Alza Corporation, Burns Doane Swecker & Mathis L, June 6, 2000: US06071305 (482 worldwide citation)

The invention relates to a directional drug delivery stent which includes an elongated or tubular member having a cavity containing a biologically active agent. In one embodiment, the active agent is diffused from the reservoir directly to the walls of a body lumen, such as a blood vessel, through d ...

Evgenia Mandrusov, Christopher J Buchko, Wouter E Roorda: Periodic constriction of vessels to treat ischemic tissue. Advanced Cardiovascular Systems, Cameron Kerrigan Squire Sanders & Dempsey L, April 8, 2003: US06544543 (217 worldwide citation)

Brief periods of occlusion of blood flow in an otherwise open target vessel adjacent to vessels supplying blood to an ischemic region are caused by periodic administration of a therapeutically effective amount of a vasoconstrictor. It is anticipated these brief periods of occlusion will induce the e ...

Wouter E Roorda, Vinayak D Bhat, Paul M Consigny: Permeabilizing reagents to increase drug delivery and a method of local delivery. Advanced Cardiovascular Systems, Squire Sanders & Dempsey L, December 16, 2003: US06663880 (210 worldwide citation)

A composition and a method for increasing the permeability of membrane junctions or cell membranes for delivery of a drug to target tissues are disclosed. Also disclosed are methods and devices for local drug delivery.

Daniel L Cox, Timothy A Limon, Wouter E Roorda: Radiopaque stent. Advanced Cardiovascular Systems, Fulwider Patton Lee & Utecht, November 25, 2003: US06652579 (124 worldwide citation)

A tubular stent formed from a plurality of cylindrical rings and connecting links where selected connecting links are of comparatively high mass in relation to the other links. The high-mass links have sufficient mass to be visible during a fluoroscopy procedure when formed from a moderately radiopa ...

Wouter E Roorda, Ni Ding, Stephen D Pacetti, Eugene T Michal, Ashok A Shah, Syed F A Hossainy: Polyacrylates coatings for implantable medical devices. Advanced Cardiovascular Systems, Squire Sanders & Dempsey L, July 24, 2007: US07247313 (96 worldwide citation)

A coating for a medical device, particularly for a drug eluting stent, is described. The coating can include a polyacrylate, a blend of polyacrylates, or a blend of the polyacrylate with other polymers, for example, poly(ethylene-co-vinyl alcohol).

Wouter E Roorda, Keith E Dionne, James E Brown, Jeremy C Wright, Craig R Davis, Steven J Prestrelski, Stelios T Tzannis: Diffusional implantable delivery system. ALZA Corporation, Burns Doane Swecker & Mathis L, October 26, 1999: US05972369 (89 worldwide citation)

A sustained release delivery system for delivering a beneficial agent is provided. The system includes a reservoir comprising the beneficial agent and a capillary channel in communication with the reservoir and the exterior of the system for delivering the beneficial agent from the system. The capil ...

Wouter E Roorda, Fred Ehnow: Viscous suspensions of controlled-release drug particles. Alza Corporation, Richard T Ito, Steven F Stone, Mary Ann Dillahunty, July 30, 1996: US05540912 (89 worldwide citation)

Controlled-release particles containing biologically effective agents such as therapeutic drugs and local anesthetics are suspended in a liquid suspending vehicle which has an elevated viscosity, the viscosity being substantially higher than that of water. Preferred vehicles are non-aqueous liquids ...

Randall G Berggren, David J Enscore, Susan M Marks, James L Osborne, Patrick S L Wong, Wouter E Roorda: Injectable drug delivery system and method. ALZA Corporation, Mary Ann Dillahunty, Steven F Stone, April 15, 1997: US05620700 (49 worldwide citation)

The present invention is directed to a material which can be used to deliver a drug, such as an antibiotic, into a diseased tissue pocket, such as a periodontal pocket. The material is preferably a bioerodible oligomer or polymer. The oligomer or polymer containing the drug is heated and is then del ...


Wouter E Roorda, Syed F A Hossainy, Ni Ding, Fuh Wei Tang, Stephen D Pacetti: Rate limiting barriers for implantable devices and methods for fabrication thereof. Advanced Cardiovascular Systems, Squire Sanders & Dempsey L, February 13, 2007: US07175873 (45 worldwide citation)

A method of coating an implantable medical device, such as a stent, is disclosed. The method includes applying a formulation on a first polymer layer containing a therapeutic substance to form a second layer. The formulation can contain a highly hydrophobic polymer or a solvent which is a poor solve ...