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Mossa Albert Carmelo, Goven Lisa May, Atwood John Girdner, Williams Fenton, Woudenberg Timothy M, Margulies Marcel, Ragusa Robert P, Leath Richard: Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control.. Perkin Elmer Cetus Instr, June 3, 1992: EP0488769-A2 (92 worldwide citation)

An instrument for performing highly accurate PCR employing a sample block in microtiter tray format. The sample block has local balance and local symmetry. A three zone film heater controlled by a computer and ramp cooling solenoid valves also controlled by the computer for gating coolant flow throu ...


2
Haff Lawrence A, Picozza Enrico, Bloch Will, Ragusa Robert, Dicesare Joseph, Tracy David, Saviano Paul, Woudenberg Timothy M: Nucleic acid amplification reaction apparatus and method.. Perkin Elmer, February 1, 1995: EP0636413-A2 (34 worldwide citation)

Apparatus and method for performing a nucleic acid amplification reaction and preferably a polymerase chain reaction (PCR) in a reaction mixture in at least one capillary tube. Several different embodiments are disclosed. One embodiment cycles a sample through a capillary tube loop passing through t ...


3
Mossa Albert Carmelo, Goven Lisa May, Atwood John Girdner, Williams Fenton, Woudenberg Timothy M, Margulies Marcel, Ragusa Robert P, Leath Richard: Apparatus and containers for performing polymerase chain reaction. Perkin Elmer, December 3, 1997: EP0810030-A1 (21 worldwide citation)

A thermocycler apparatus for performing polymerase chain reaction (PCR) comprises a heating block (12) and heated cover (14) in which sample tubes (324,326) are retained, heated and cooled as required. The heating of the upper portions and caps of sample tubes (324,326) in use prevents condensation ...


4
Mossa Albert Carmelo, Goven Lisa May, Atwood John Girdner, Williams Fenton, Woudenberg Timothy M, Margulies Marcel, Ragusa Robert P, Leath Richard: Automated performance of polymerase chain reaction. Perkin Elmer, November 28, 2001: EP1157744-A1 (13 worldwide citation)

Apparatus for performing quantitative PCR has wells formed in a metal sample block, constant bias cooling to cool the block uniformly at a rate of 0.1 DEG C/sec and computer controlled uniform heating of the sample block at a rate greater than the rate of cooling in the absence of heating.


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Mossa Albert, Woudenberg Timothy M, Goven Lisa, Margulies Marcel, Atwood John Girdner, Ragusa Robert, Williams Fenton, Leath Richard: Performing polymerase chain reaction. Applera, March 2, 2005: EP1510823-A2 (12 worldwide citation)

Disposable polypropylene tubes are used as reaction containers for performing polymerase chain reaction (PCR) on samples of nucleic acids. The tubes have a lower conical portion and an upper cylindrical portion. The tubes are capped in use. The lower portion contacts a correspondingly shaped hole in ...


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Mossa Albert Carmelo, Goven Lisa May, Atwood John Girdner, Williams Fenton, Woudenberg Timothy M, Margulies Marcel, Ragusa Robert P, Leath Richard: Automated performance of the polymerase chain reaction. Perkin Elmer, December 17, 1997: EP0812621-A1 (11 worldwide citation)

An instrument for performing highly accurate PCR employing a sample block in microtiter tray format. The sample block has local balance and local symmetry. A three zone film heater controlled by a computer and ramp cooling solenoid valves also controlled by the computer for gating coolant flow throu ...


7
Woudenberg Timothy M, Bodner Kevin S, Connell Charles R, Ganz Alan M, Mcbride Lincoln J, Saviano Paul G, Shigeura John, Tracy David H, Young Eugene F, Lee Linda G: System for real time detection of nucleic acid amplification products. Perkin Elmer, April 17, 1996: EP0706649-A1 (11 worldwide citation)

A system is provided for carrying out real time fluorescence-based measurements of nucleic acid amplification products. In a preferred embodiment of the invention, an excitation beam is focused into a reaction mixture through a surface, the reaction mixture containing (i) a first fluorescent indicat ...


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Mossa Albert C, Goven Lisa M, Atwood John G, Williams Fenton, Woudenberg Timothy M, Margulies Marcel, Ragusa Robert P, Leath Richard: Systeme de cyclage thermique pour optimiser par voie automatique la pcr avec regulation precise de la temperature, Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control. Perkin Elmer Cetus Instruments, BORDEN LADNER GERVAIS, April 13, 1999: CA2056743 (3 worldwide citation)

An instrument for performing highly accurate PCR employing a sample block in microtiter tray format. The sample block has local balance and local symmetry. A three zone film heater controlled by a computer and ramp cooling solenoid valves also controlled by the computer for gating coolant flow throu ...


10
Sharaf Muhammad A, Woudenberg Timothy M, Mullah Khairuzzaman Bashar: Methods of detecting target nucleic acids. Applera Corporation, Sharaf Muhammad A, Woudenberg Timothy M, Mullah Khairuzzaman Bashar, BECKER Daniel M, October 18, 2007: WO/2007/117832 (3 worldwide citation)

The present disclosure relates to methods of identifying target nucleic acids by using coded molecules and its analysis by translocation through a nanopore. Generally, coded molecules are subject to a target polynucleotide dependent modification. The modified coded molecule is detected by isolating ...