1
Woonza M Rhee, Frank A DeLustro, Richard A Berg: Crosslinked polymer compositions and methods for their use. Cohesion Technologies, Laurie A Axford, Foley & Lardner, April 18, 2000: US06051648 (500 worldwide citation)

Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has bee ...


2
Woonza M Rhee, Richard A Berg, George H Chu, Frank A DeLustro, Dan M Jolivette, Kimberly A McCullough: Injectable or implantable biomaterials for filling or blocking lumens and voids of the body. Collagen Corporation, Morrison & Foerster, May 19, 1998: US05752974 (490 worldwide citation)

Methods for completely or partially blocking, augmenting, sealing, or filling various biological lumens and voids within the body of a patient are disclosed. Lumens include arteries, veins, intestines, Fallopian tubes, and trachea. Voids include various lesions, fissures, diverticulae, cysts, fistul ...


3
Woonza M Rhee, Frank A DeLustro, Richard A Berg: Crosslinked polymer compositions and methods for their use. Cohesion Technologies, Fish & Richardson P C, February 23, 1999: US05874500 (345 worldwide citation)

Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has bee ...


4
Woonza M Rhee, Frank A DeLustro, Richard A Berg: Method of using crosslinked polymer compositions in tissue treatment applications. Cohesion Technologies, Morrison & Foester, December 26, 2000: US06166130 (247 worldwide citation)

Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has bee ...


5
Donald G Wallace, Gregory M Cruise, Woonza M Rhee, Jacqueline Anne Schroeder, George T Coker III, Marcee M Maroney: Rapid gelling biocompatible polymer composition. Cohesion Technologies, Dianne E Reed, Laurie A Axord, November 6, 2001: US06312725 (217 worldwide citation)

This invention relates generally to two-part polymer compositions that rapidly form covalent linkages when mixed together. Such compositions are particularly well suited for use in a variety of tissue related applications when rapid adhesion to the tissue and gel formation is desired. In particular, ...


6
Woonza M Rhee, Richard A Berg: Glycosaminoglycan-synthetic polymer conjugates. Collagen Corporation, Kathi Rafayko, Shirley L Church, April 23, 1996: US05510418 (182 worldwide citation)

Pharmaceutically acceptable, nonimmunogenic compositions are formed by covalently binding glycosaminoglycans or derivatives thereof, to hydrophilic synthetic polymers via specific types of chemical bonds to provide biocompatible conjugates. Useful glycosaminoglycans include hyaluronic acid, the chon ...


7
Jeffrey E Yeung, George H Chu, Frank A DeLustro, Woonza M Rhee: Anti-adhesion films and compositions for medical use. Collagen Corporation, Laurie A Axford, Shirley L Church, Wilhelmus J Wytenburg, December 3, 1996: US05580923 (157 worldwide citation)

Anti-adhesion films useful for the prevention of surgical adhesions are disclosed. These films comprise substrate materials (such as collagen) and hetero-bifunctional anti-adhesion binding agents, wherein the substrate material is covalently linked to receptive tissue within the body of a patient vi ...


8
Woonza M Rhee, Prema R Rao, George H Chu, Frank A DeLustro, Carol F H Harner, Naomi Sakai, Jacqueline A Schroeder: Collagen-based bioadhesive compositions. Collagen Corporation, Kathi Rafayko, March 25, 1997: US05614587 (155 worldwide citation)

Collagen-based compositions useful in the attachment of tissues, or the attachment of tissues to synthetic implant materials, are disclosed. The compositions comprise collagen crosslinked using a multifunctionally activated synthetic hydrophilic polymer. A particularly preferred composition comprise ...


9
Woonza M Rhee, Richard A Berg, Joel S Rosenblatt, Jacqueline A Tefft, Larry J Braga, Thomas L Smestad: Method of preparing crosslinked biomaterial compositions for use in tissue augmentation. Collagen Corporation, Kathi Rafayko, August 27, 1996: US05550187 (144 worldwide citation)

The present invention discloses a novel method for preparing crosslinked biomaterial compositions for use in the augmentation of soft or hard tissue. In general, the method comprises mixing a biocompatible polymer, which is preferably collagen, with a sterile, dry crosslinking agent, which is prefer ...


10
Woonza M Rhee, Richard A Berg: Collagen-synthetic polymer matrices prepared using a multiple step reaction. Collagen Corporation, Kathi Rafayko, December 12, 1995: US05475052 (136 worldwide citation)

The present invention discloses collagen-synthetic polymer matrices which are prepared using a multiple step reaction. The first step of the reaction generally involves reacting collagen with a functionally activated synthetic hydrophilic polymer to form a collagen-synthetic polymer matrix. The synt ...