1
Wong Vernon G: Ocular implants.. Visionex, June 5, 1991: EP0430539-A2 (108 worldwide citation)

Ocular implants are formed so as to be insertable in the suprachoroid of the eye, preferably in the form of plaques 0.5 to 10 mm x 0.5 to 10 mm, and 0.25 to 1.0 mm thick. They are made from a pharmacologically acceptable biodegradable polymer, such as a polyester, incorporating an active agent for t ...


2
Wong Vernon G: Composition comprising biodegradable ocular implants.. Wong Vernon G, June 28, 1989: EP0322319-A2 (33 worldwide citation)

Microencapsulated drugs are proposed for introduction into the chambers of the eye for therapeutic purposes. The administration of drugs is controlled and maintained for long periods of time, while ensuring the substantial absence of significant levels outside the site of administration.


3
WONG VERNON G: Implantable mems intraocular pressure sensor devices and methods for glaucoma monitoring. ORTHOMEMS, Shimmick John K, March 24, 2011: WO/2011/035228 (33 worldwide citation)

An implantable device for measuring IOP comprises a distal portion, a proximal portion and a conformable elongate support extending between the distal portion and the proximal portion. The distal portion comprises a pressure sensor, for example a capacitor, and the proximal portion comprises a coil. ...


4
WONG VERNON G: Implantable ophthalmic mems sensor devices and methods for eye surgery. ORTHOMEMS, Shimmick John K, March 24, 2011: WO/2011/035262 (33 worldwide citation)

Methods and apparatus for measurement of IOP following glaucoma surgery comprise an implant device having a pressure sensitive capacitor and coil sized for placement along the tissue drainage path, to monitor the success of the surgery and measure IOP directly. The implantable sensor device may comp ...


5
WONG Vernon G, LEE Douglas A: CAPTEUR DE PRESSION IMPLANTABLE EXPANSIBLE POUR CHIRURGIE INTRAOCULAIRE, EXPANDABLE IMPLANTABLE PRESSURE SENSOR FOR INTRAOCULAR SURGERY. ORTHOMEMS, WONG Vernon G, LEE Douglas A, HESLIN James M, March 22, 2012: WO/2012/037455 (31 worldwide citation)

Implantable pressure sensors provide for the direct measurement of IOP, for example following cataract surgery. The implantable sensors can couple to the capsule, for example separately from an IOL (intraocular lens), such that the sensor can be used with many commercially available IOLs. The surgeo ...


6
Wong Vernon G: Intraocular implants for preventing transplant rejection in the eye. Allergan, July 6, 2005: EP1550471-A1 (13 worldwide citation)

An intraocular biodegradable drug delivery system comprising a steroidal anti-inflammatory agent mixed with a bioerodible polymer is useful for preventing or reducing neovascularizsation in an eye prone to neovascularization.


7
Wong Vernon G, Hu Mae W L, Berger Donald E Jr: Procedes et dispositifs implantables servant a administrer un medicament oculaire biocompatible a liberation controlee, Controlled-release biocompatible ocular drug delivery implant devices and methods. Allergan, Allergan, BORDEN LADNER GERVAIS, CA2544460 (5 worldwide citation)

Controlled release devices are disclosed which arebiocompatible and can be implanted into the eye. The devices havea core comprising a drug and a polymeric outer layer which issubstantially impermeable to the entrance of an environmentalfluid and substantially impermeable to the release of the drugd ...


8
Wong Vernon G, Kochinke Frank: Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents. Allergan, November 17, 2004: EP1477187-A1 (4 worldwide citation)

Combinations of hydrophilic and hydrophobic entities in a biodegradable sustained release implant are shown to modulate each other's rate of release. Formulations of a therapeutically active agent and modulator provide substantially constant rate of release for an extended period of time.


9
Wong Vernon G, Hu Mae W L: Methods for treating inflammation-mediated conditions of the eye. Oculex Pharmaceuticals, Wong Vernon G, Hu Mae W L, sSHORTLE Rebecca, January 10, 2002: WO/2002/002076 (3 worldwide citation)

Methods for treating inflammation-mediated conditions of the eye are described, comprising: implanting into the vitreous of the eye of an individual a bioerodible implant comprising a steroidal anti-inflammatory agent and a bioerodible polymer, wherein the implant delivers the agent to the vitreous ...


10
Wong Vernon G: Intraocular implants for preventing transplant rejection in the eye. Oculex Pharmaceuticals, Wong Vernon G, sREILLY Philip D, June 6, 2002: WO/2002/043785 (3 worldwide citation)

Methods for reducing or preventing transplant rejection in the eye of an individual are described, comprising: a) performing an ocular transplant procedure; and b) implanting in the eye a bioerodible drug delivery system comprising an immunosuppressive agent and a biorodible polymer.