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Wolf Bertling: Method for exchanging homologous DNA sequences in a cell using polyoma encapsulated DNA fragments. Bell Seltzer Park & Gibson, August 21, 1990: US04950599 (36 worldwide citation)

A method for altering a cell by exchanging a preselected cellular DNA sequence with an exogenous DNA sequence different from the cellular DNA sequence employs an exogenous DNA sequence encapsidated in a polyoma or polyoma-like capsid. The polyoma capsid is then contacted to the cell so that the exog ...


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Wolf Bertling, Hans Kosak: Method for marking solid, liquid or gaseous substances. november Aktiengesellschaft Gesellschaft fur Molekulare Medizin, Fish & Richardson P C P A, July 17, 2001: US06261809 (18 worldwide citation)

The invention relates to a method for marking solid, liquid or gaseous substances, whereby the substance to be marked is provided with at least one synthetically produced nucleic acid sequence. Said nucleic acid sequence contains a first sequence section constructed with the 5′ terminal end, a secon ...


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Wolf Bertling: Method and apparatus for processing nucleic acids using a small temperature-changing zone. Boehringer Mannheim, Nikaido Marmelstein Murray & Oram, November 16, 1999: US05985555 (8 worldwide citation)

Method and device for processing nucleic acids in a reaction mixture on a surface that can be temperature-controlled and its immediate vicinity wherein the main space of the reaction mixture remains essentially isothermal. The method has the advantage of a very short processing time.


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Wolf Bertling: Method for purifying and enriching molecules. Pearne & Gordon, November 12, 2002: US06479644 (8 worldwide citation)

The invention relates to a process for purifying and concentrating charge-bearing first molecules


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Wolf Bertling: Method for detecting a nucleotide sequence. November Aktiengesellschaft Gesellschaft fuer Molekulare Medizin, Laurence A Greenberg, Werner H Stemer, Gregory L Mayback, June 11, 2002: US06403339 (8 worldwide citation)

A method is disclosed for detecting a nucleotide sequence by a polymerase chain reaction, the nucleotide sequence is a constituent of a double-stranded nucleic acid molecule which is in solution and formed of a strand and a counter-strand. A first primer is added to the solution and is complementary ...


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Wolf Bertling: Vehicle for the transport of molecular substances. Vanophem Meehan & Vanophem P C, December 26, 2000: US06165772 (7 worldwide citation)

The invention relates to a vehicle for the transport of molecular substance, such as DNA, RNA, protein, PNA, pharmaceuticals of lipophilic and lipophobic character, into eukaryotic cells comprising at least one capsomere derived or originating from a virus, which on one of its sides interacts with t ...


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Wolf Bertling: Vectorial cloning system of DNA. November Novus Medicatus Berling Gesellschaft fur Molekulare Medizin, Fish & Richardson P C P A, February 13, 2001: US06187589 (5 worldwide citation)

The invention relates to a vectorial cloning system consisting of a sequence of nucleotides, containing a fusion sequence and one or several restriction endonucleases, recognition sites for restriction endonucleases cutting outside their recognition sites, in addition to containing one or several ot ...


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Wolf Bertling: Method and device for preparing samples for detecting a nucleotide sequence. November Aktiengesellschaft Gesellschaft fur Molekulare Medizin, Rankin Hill Porter & Clark, August 27, 2002: US06440724 (3 worldwide citation)

A method for preparing samples for detecting a nucleotide sequence by polymerase chain reaction (PCR) according to which a) an analysis solution is filled into at least one cavity (