1
Sébastien François Emmanuel Lemaire, Andras Horvath, Wim Albert Alex Aelterman, Thomas Joachim Landewald Rammeloo: Methods for the preparation of hexahydrofuro[2,3-B]furan-3-ol. Janssen Pharmaceutica, Woodcock Washburn, April 10, 2012: US08153829

Methods for the preparation of hexahydrofuro[2,3-b]furan-3-ol and especially its enantiomer (3R,3aS,6aR) hexahydrofuro[2,3-b]furan-3-ol, as well as certain novel intermediates for use in such methods are disclosed.


2
Piet Tom Bert Paul Wigerinck, Dominique Louis Nestor Ghislain Surleraux, Wim Gaston Verschueren, Herman Augustinus De Kock, Wim Albert Alex Aelterman: Process for the preparation of (3R,3aS,6aR)-hexahydrofuro [2,3-b] furan-3-yl (1S,2R)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate. Janssen R&D Ireland, Michael J Atkins, November 12, 2013: US08580981

The present invention relates to a process for the preparation of (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-hydroxypropylcarbamate as well as novel intermediates for use in said process. (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl(1S,2 ...


3
Jean François Alexandre Lucas Hegyi, Wim Albert Alex Aelterman, Yolande Lydia Lang, Sigrid Carl Maria Stokbroekx, Carina Leys, Peter Jozef Maria Van Remoortere, Anne Faure: Fumarate salt of (alpha S, beta R)-6-bromo-alpha-[2-(dimethylamino)ethyl]-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol. Janssen Pharmaceutica, Thomas J Dodd, October 1, 2013: US08546428

The present invention relates to the fumarate salt of (alpha S, beta R)-6-bromo-alpha-[2-(dimethylamino)ethyl]-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol, pharmaceutical compositions comprising as active ingredient said salt and to processes for their preparation.


4
Eduard Jozef Contantia Vreysen, Joannes Petrus Van Dun, Wim Albert Alex Aelterman: -pyrido[1,2-A]pyrimidin-4-one, Preparation of 9-hydroxy-3-(2-hydroxyethyl)-2-methyl-4. Janssen Pharmaceutica, May 25, 2010: US07723518

The present invention concerns a process for preparing crystalline 3-(2-chloro-ethyl)-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one substantially free of 2-acetylbutyrolactone.


5
Herman Augustinus De Kock, Walter Ferdinand Maria Filliers, Wim Albert Alex Aelterman: Methods for the preparation of benzoxazole sulfonamide compounds and intermediates thereof. Philip S Johnson, Johnson & Johnson, May 31, 2007: US20070123574-A1

The present invention relates to methods for the preparation of benzoxazole sulfonamide compounds as well as novel intermediates for use in said method. More in particular the invention relates to methods for the preparation of 2-amino-benzoxazole sulfonamide compounds which make use of 2-mercapto-b ...


6
Eduard Jozef Contantia Vreysen, Joannes Petrus Van Dun, Wim Albert Alex Aelterman: Preparation Of 9-Hydroxy -(2-Hydroxyethyl)-2-Methyl-4H-Pyrido[1,2-A]Pryimidin-4-One. Janssen Pharmaceutica, Philip S Johnson, Johnson & Johnson, November 8, 2007: US20070260061-A1

The present invention concerns a process for preparing crystalline 3-(2-chloro-ethyl)-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one substantially free of 2-acetylbutyrolactone.


7
Piet Tom Bert Paul Wigerinck, Dominique Louis Nestor Ghislain Surleraux, Wim Gaston Verschueren, Herman Augustinus De Kock, Wim Albert Alex Aelterman: Process for the preparation of (3r,3as,6ar)-hexahydrofuro [2,3-b] furan-3-yl (1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate. June 30, 2011: US20110160468-A1

The present invention relates to a process for the preparation of (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-hydroxypropylcarbamate as well as novel intermediates for use in said process. (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl(1S,2 ...


8
Jean Francois Alexandre Lucas Hegyi, Wim Albert Alex Aelterman, Yolande Lydia Lang, Sigrid Carl Maria Stokbroekx, Carina Leys, Peter Josef Maria Van Remoortere, Anne Faure: Fumarate salt of (alpha s, beta r)-6-bromo-alpha-[2-(dimethylamino)ethyl]-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol. Philip S Johnson, Johnson & Johnson, February 4, 2010: US20100028428-A1

The present invention relates to the fumarate salt of (alpha S, beta R)-6-bromo-alpha-[2-(dimethylamino)ethyl]-2-methoxy-alpha-1 -naphthalenyl-beta-phenyl-3-quinolineethanol, pharmaceutical compositions comprising as active ingredient said salt and to processes for their preparation.


9
Sébastien François Emmanuel Lemaire, Andras Horvath, Wim Albert Alex Aelterman, Thomas Joachim Landewald Rammeloo: METHODS FOR THE PREPARATION OF HEXAHYDROFURO[2,3-b]FURAN-3-OL. Tibotec Pharmaceuticals, Philip S Johnson, Johnson & Johnson, April 15, 2010: US20100094028-A1

Methods for the preparation of hexahydrofuro[2,3-b]furan-3-ol and especially its enantiomer (3R,3aS,6aR) hexahydrofuro[2,3-b]furan-3-ol, as well as certain novel intermediates for use in such methods.



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