1
Thomas J Dougherty, William R Potter, Kenneth R Weishaupt: Drugs comprising porphyrins. Health Research, Vincent L Carney, March 10, 1987: US04649151 (166 worldwide citation)

To obtain tumor-selective, photosensitizing drugs useful in the localization of neoplastic tissue and treatment of abnormal neoplastic tissue such as tumors, one of two methods is used. In the first method, a hydrolyzed mixture of the products of reaction of hematoporphyrin with acetic acid and sulf ...


2
Thomas J Dougherty, William R Potter, Kenneth R Weishaupt: Methods for treatment of tumors. Health Research, Irell & Manella, June 12, 1990: US04932934 (127 worldwide citation)

To obtain tumor-selective, photosensitizing drugs useful in the localization of neoplastic tissue and treatment of abnormal neoplastic tissue such as tumors, one of two methods is used. In the first method, a hydrolyzed mixture of the products of reaction of hematoporphyrin with acetic acid and sulf ...


3
Thomas J Dougherty, William R Potter, Kenneth R Weishaupt: Hematoporphyrin derivatives and process of preparing. Health Research, Irell & Manella, September 12, 1989: US04866168 (84 worldwide citation)

To obtain tumor-selective, photosensitizing drugs useful in the localization of neoplastic tissue and treatment of abnormal neoplastic tissue such as tumors, one of two methods is used. In the first method, a hydrolyzed mixture of the products of reaction of hematoporphyrin with acetic acid and sulf ...


4
Thomas J Dougherty, William R Potter, Kenneth R Weishaupt: Drugs comprising porphyrins. Health Research, Irell & Manella, July 2, 1991: US05028621 (70 worldwide citation)

To obtain tumor-selective, photosensitizing drugs useful in the localization of neoplastic tissue and treatment of abnormal neoplastic tissue such as tumors, one of two methods is used. In the first method, a hydrolyzed mixture of the products of reaction of hematoporphyrin with acetic acid and sulf ...


5
Thomas J Dougherty, William R Potter, Kenneth R Weishaupt: Apparatus for treatment of tumors. Health Research, Irell & Manella, December 26, 1989: US04889129 (62 worldwide citation)

To provide to and receive radiation from a photodynamic drug in neoplastic tissue, a laser system transmits radiation through an interface into a radiation delivery system, which is in juxtaposition with neoplastic tissue containing a photodynamic drug. The laser system may be a single argon laser p ...


6
William R Potter: Fiber optic diffusers and methods for manufacture of the same. Health Research, Irell & Manella, December 24, 1991: US05074632 (62 worldwide citation)

The present invention relates to improvements on fiberoptic diffusers for use in PDT and methods of making the same. This invention discloses a fiberoptic cylindrical diffuser dispersing light outwardly in a cylindrical scattering pattern which includes a fiber with a jacket-stripped core tip, a thi ...


7
William R Potter: In vivo fluorescence photometer. Health Research, Steven P Koda, April 27, 1993: US05205291 (53 worldwide citation)

A method and apparatus for in vivo detection of abnormal tissue in patients by irradiating a diagnostic region simultaneously with at least two wavelengths of incident light, and detecting the resulting fluorescence of normal and abnormal tissue. The patient is provided with a photosensitizer which ...


8
William R Potter: In vivo fluorescence photometer. Health Research, Irell & Manella, November 5, 1991: US05062431 (49 worldwide citation)

A method and apparatus for in vivo detection of abnormal tissue in patients by irradiating a diagnostic region simultaneously with at least two wavelengths of incident light, and detecting the resulting fluorescence of normal and abnormal tissue. The patient is provided with a photosensitizer which ...


9
Leroy Wood, Donn Boyle, William R Potter: Submersible lens fiberoptic assembly for use in PDT treatment. Health Research, James F Mudd, Michael L Dunn, March 2, 1993: US05190536 (45 worldwide citation)

A submersible lens fiberoptic assembly for PDT treatment includes an optical fiber, a fiber jacket, a ball lens made of zirconia and a housing. This fiberoptic assembly is simple and inexpensive to manufacture, and has a high quality of output light beam. A submersible lens fiberoptic assembly for P ...


10
William R Potter: Backscatter monitoring system. Health Research, June 15, 1993: US05219345 (33 worldwide citation)

A system for monitoring the condition of the distal tip of an optical treatment fiber, including a monitor for measuring the intensity of light backscattered from the distal tip. A treatment laser is coupled to a jumper fiber, which has its distal end optically coupled to the proximal end of the tre ...