1
William N Drohan, Martin J MacPhee, Shirley I Miekka, Manish S Singh, Clive Elson, John R Taylor Jr: Chitin hydrogels, methods of their production and use. Chitogenics, The American National Red Cross, Coalition for Hemophilia B, Lahive & Cockfield, September 26, 2000: US06124273 (165 worldwide citation)

This invention is directed to the preparation and utilization of supplemented chitin hydrogels, such as chitosan hydrogels. Further provided are biomaterials comprising same. The particular supplement delivered by the chitin hydrogel is selected as a function of its intended use. In one embodiment, ...


2
Martin MacPhee, Glenn Calvert, Tom Lynch, Randall S Kent, David Mann, Wilson Burgess, Shirley Miekka, William N Drohan: Methods for sterilizing biological materials by irradiation over a temperature gradient. Clearant, Morgan Lewis & Bockius, June 21, 2005: US06908591 (160 worldwide citation)

Methods are disclosed for sterilizing tissue to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria, (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, ...


3
Shirley I Miekka, Wilson Burgess, William N Drohan, Yuri Griko, Martin J MacPhee, David M Mann: Methods for sterilizing biological materials. Clearant, Morgan Lewis & Bockius, September 20, 2005: US06946098 (120 worldwide citation)

Methods are disclosed for sterilizing biological materials to reduce the level therein of one or more biological contaminants or pathogens, such as prions, responsible for the disease states known as transmissible spongiform encephalopathies (TSEs) in mammals. These methods involve sterilizing biolo ...


4
Willson H Burgess, Howard P Greisler, William N Drohan, Thomas Maciag, Martin J MacPhee: Method of preparing a tissue sealant-treated biomedical material. Loyola University of Chicago, The American National Red Cross, Sterne Kessler Goldstein & Fox P L L C, May 6, 2003: US06559119 (84 worldwide citation)

This invention provides methods for the preparation of a tissue sealant-treated biomaterial, wherein the tissue sealant used in the method comprises at least one composition which is selected from one or more antibodies, analgesics, anticoagulants, anti-inflammatory compounds, antimicrobial composit ...


5
Henryk Lubon, William N Drohan, William H Velander: Transgenic mammals expressing human coagulation factor VIII. American National Red Cross, Foley & Lardner, March 9, 1999: US05880327 (55 worldwide citation)

A non-human transgenic mammalian animal, as described above, contains an exogenous double stranded DNA sequence stably integrated into the genome of the animal, which comprises cis-acting regulatory units operably linked to a DNA sequence encoding human Factor VIII protein and a signal peptide, wher ...


6
Shirley I Miekka, William N Drohan, Thomas R Jameson, John R Taylor Jr, Manish S Singh: Methods of production and use of liquid formulations of plasma proteins. The American National Red Cross, Coalition for Hemophilia B, Sterne Kessler Goldtein & Fox PLLC, November 20, 2001: US06320029 (44 worldwide citation)

The present invention relates to the preparation and use of liquid formulations of plasma proteins, particularly blood coagulation factors. More specifically, the present invention relates to stable liquid formulations of Factor VIII and Factor IX that can be administered by injection or infusion to ...


7
William N Drohan, Martin J MacPhee, Hernan Nunez, Gene Liau, Thomas Maciag, Wilson H Burgess: Methods for treating wound tissue and forming a supplemented fibrin matrix. The American National Red Cross, Sterne Kessler Goldstein & Fox P L L C, March 27, 2007: US07196054 (37 worldwide citation)

This invention provides supplemented and unsupplemented tissue sealants as well as methods for their production and use thereof. Disclosed are tissue sealants supplemented with at least one antimicrobial composition. The composition may be further supplemented with, for example, one or more antibodi ...


8
William N Drohan, Martin J MacPhee, Wilson H Burgess, Hernan Nunez, Manish Singh, Gene Liau, Thomas Maciag: Supplemented and unsupplemented tissue sealants, methods of their production and use. The American National Red Cross, Stern Kessler Goldstein & Fox P L L C, March 13, 2007: US07189410 (33 worldwide citation)

This invention provides a fibrin sealant bandage, wherein said fibrin sealant may be supplemented with at least one composition selected from, for example, one or more regulatory compounds, antibody, antimicrobial compositions, analgesics, anticoagulants, antiproliferatives, anti-inflammatory compou ...


9
Randall S Kent, William N Drohan: Methods for the selective separation of organic components from biological fluids. American National Red Cross, Morrison & Foerster, February 27, 2001: US06193891 (32 worldwide citation)

The present invention pertains to improved methods for the selective separation of organic components from biological fluids. More particularly, the present invention pertains to methods for the selective separation of organic components from biological fluids which comprise the step of contacting t ...


10
Shirley I Miekka, William N Drohan, Annemarie Ralston, Hao Xue: Pathogen inactivating compositions for disinfecting biological fluids. American National Red Cross, Burns Doane Swecker & Mathis L, August 22, 2000: US06106773 (29 worldwide citation)

The present invention is directed to pathogen inactivating compositions that can be used to disinfect various biological fluids, such as blood, blood fractions, and the like. The compositions are suitable for disinfecting biological fluids containing valuable, but labile, components such as proteins ...