1
William J Houlihan, Jeffrey Nadelson: Acyl benzyl ethers. Sandoz, Gerald D Sharkin, Robert S Honor, August 31, 1976: US03978132 (50 worldwide citation)

Acyl substituted or unsubstituted benzyl ethers, e.g., p-(phenoxymethyl)pivalophenone, are prepared by reacting a corresponding .alpha.-bromo-p-pivaloyl toluene with a corresponding phenol and are useful as hypolipidemic agents.


2
William J Houlihan, Jeffrey Nadelson: 3-Substituted-4-aryl isoquinolines. Sandoz, Gerald D Sharkin, Robert S Honor, November 2, 1976: US03989704 (21 worldwide citation)

3-Substituted-4-aryl isoquinolines, e.g. 3-tertiary butyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline, prepared from corresponding isoquinoline intermediates, are useful as anti-diabetic agents.


3
William J Houlihan: 5-hetero-or aryl-substituted-imidazo(2,1-a)isoquinolines and their use as PAF receptor antagonists. Sandoz Pharmaceuticals, Gerald D Sharkin, Robert S Honor, Joseph J Borovian, March 20, 1990: US04910206 (16 worldwide citation)

The invention discloses certain 5-hetero or aryl-substituted-imidazo[2,1-a]isoquinolines useful as platelet activating factor (PAF) receptor antagonists, pharmaceutical compositions containing said compounds as an active ingredient thereof and a method of using such compositions for inhibiting PAF-m ...


4
William J Houlihan, Seung H Cheon: 5-aryl-substituted-2,3-dihydro-imidazo[1,2-a]furo- and thieno pyridines. Sandoz Pharm, Gerald D Sharkin, Robert S Honor, Joseph J Borovian, February 12, 1991: US04992428 (15 worldwide citation)

The invention discloses certain 5-aryl-substituted,2,3-dihydro-imidazo[1,2-a]furo- and thieno pyridines useful as PAF receptor antagonists and for treating tumors, pharmaceutical compositions containing said compounds as an active ingredient thereof and a method of using such compositions for inhibi ...


5
Dietmar A Habeck, William J Houlihan: Substituted indeno, naphtho and cyclohepta pyrazoles. Sandoz, Gerald D Sharkin, Robert S Honor, Thomas O McGovern, January 13, 1976: US03932430 (13 worldwide citation)

Substituted indeno [1,2-c] pyrazoles, naphtho [1,2-c] pyrazoles and benzo [6,7] cyclohepta [1,2-c] pyrazoles e.g., 3-(2,3-dimethoxyphenyl)-4H-indeno[1,2-c] pyrazole and 4,5-dihydro-3-(4-pyridyl)-2H-naphtho[1,2-c] pyrazole, are useful as non-estrogenic anti-fertility agents and antihypertensive agent ...


6
William J Houlihan: Hydroxyalkyl substituted-4,5-dihydropyridazin(2H)-3-ones. Sandoz, Gerald D Sharkin, Robert S Honor, Thomas O McGovern, January 6, 1976: US03931176 (12 worldwide citation)

Hydroxyalkyl and aryl or heterocyclic substituted-4,5-dihydropyridazin(2H)-3-ones and diazabicyclo-ene-ones e.g., 6-(p-chloro-phenyl)-2-(2-hydroxybutyl)-4,5-dihydropyridazin(2H)-3-on e are prepared by condensing 1-hydrazino-2-alkanols with aryl or heterocyclic-.gamma.-keto acids and are useful as ce ...


7
Robert C Anderson, William J Houlihan, Howard C Smith, Edwin B Villhauer: Diaryl substituted cyclopentane and cyclopentene derivatives. Sandoz Pharm, Gerald D Sharkin, Robert S Honor, Joseph J Borovian, July 4, 1989: US04845129 (12 worldwide citation)

The invention discloses certain diaryl substituted cyclopentane and cyclopentene derivatives useful as PAF inhibitors, pharmaceutical compositions containing said compounds as an active ingredient thereof and a method of using such compositions for inhibiting PAF-induced blood platelet aggregation, ...


8
William J Houlihan, Mark L Lee: Substituted-[hydroxy(tetrahydro)-5-oxo-(2- and 3-furanyl or 2-thienyl)alkoxyphosphinyloxy]-alkanaminium hydroxide, inner salt oxides. Sandoz Pharmaceuticals, Gerald D Sharkin, Robert S Honor, Joseph J Borovian, June 16, 1987: US04673672 (8 worldwide citation)

The invention discloses substituted 2-[hydroxy(tetrahydro)-5-oxo-(2- and 3-furanyl or 2-thienyl) alkoxyphosphinyloxy]-alkanaminium hydroxide inner salt-4-oxides useful as anti-tumor agents, pharmaceutical compositions containing said compounds as an active ingredient thereof and a method of using su ...


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William J Houlihan, Jeffrey Nadelson: Alkanoyl substituted benzoic acids and esters. Sandoz, Gerald D Sharkin, Robert S Honor, Timothy G Rothwell, March 29, 1977: US04015010 (7 worldwide citation)

Alkanoyl substituted benzoic acids and esters, e.g., p-pivaloyl ethyl benzoate, are prepared by oxidizing alkanoyl substituted toluene and reacting with lower alkanols and are useful as hypolipidemic, anti-obesity, and anti-diabetic agents.