1
Stephen P A Fodor, Dennis W Solas, William J Dower: Method of detecting nucleic acids. September 1, 1998: US05800992 (549 worldwide citation)

The present invention provides method and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and ...


2
William J Dower, Steven E Cwirla: Recombinant library screening methods. Affymax Technologies, Townsend & Townsend & Crew, December 3, 1996: US05580717 (489 worldwide citation)

Nucleotide sequences encoding proteins of interest are isolated from DNA libraries using bacteriophage to link the protein to the sequence which encodes it. DNA libraries are prepared from cells encoding the protein of interest and inserted into or adjacent to a coat protein of a bacteriophage vecto ...


3
William J Dower, Steven E Cwirla: Recombinant library screening methods. Affymax Technologies, Townsend and Townsend Khourie and Crew, June 27, 1995: US05427908 (451 worldwide citation)

Nucleotide sequences encoding proteins of interest are isolated from DNA libraries using bacteriophage to link the protein to the sequence which encodes it. DNA libraries are prepared from cells encoding the protein of interest and inserted into or adjacent to a coat protein of a bacteriophage vecto ...


4
William J Dower, Stephen P A Fodor: Sequencing of surface immobilized polymers utilizing microflourescence detection. Affymax Technologies, Townsend & Townsend & Crew, August 20, 1996: US05547839 (397 worldwide citation)

Means for simultaneous parallel sequence analysis of a large number of biological polymer macromolecules. Apparatus and methods may use fluorescent labels in repetitive chemistry to determine terminal monomers on solid phase immobilized polymers. Reagents which specifically recognize terminal monome ...


5
Stephen P A Fodor, Dennis W Solas, William J Dower, Xiaohua C Huang: Oligonucleotides. Affymetrix, Morgan Lewis & Bockius, June 24, 2003: US06582908 (355 worldwide citation)

The present invention provides a number of oligonucleotide sequences which can be used for a wide variety of analyses applicable to the diverse fields impacted by the nature of molecular interaction, including chemistry, biology, medicine, and medical diagnostics. In certain embodiments these oligon ...


6
William J Dower, Ronald W Barrett, Mark A Gallop, Michael C Needels: Synthesizing and screening molecular diversity. Affymax Technologies, Kevin Kaster, Vern Norviel, Lauren L Stevens, June 17, 1997: US05639603 (289 worldwide citation)

A general stochastic method for synthesizing compounds can be used to generate large collections of tagged compounds that can be screened to identify and isolate compounds with useful properties.


7
William J Dower, Steven E Cwirla, Ronald W Barrett: Peptide library and screening systems. Affymax Technologies, Townsend and Townsend Khourie and Crew, July 11, 1995: US05432018 (179 worldwide citation)

Peptides which bind to selected receptors are identified by screening libraries which encode a random or controlled collection of amino acids. Peptides encoded by the libraries are expressed as fusion proteins of bacteriophage coat proteins, and bacteriophage are then screened against the receptors ...


8
Stephen P A Fodor, Dennis W Solas, William J Dower: Products for detecting nucleic acids. Affymetrix lnc, Morgan Lewis & Bockius, March 12, 2002: US06355432 (175 worldwide citation)

The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and ...


9
William J Dower, Gregory L Heinkel, Larry Mattheakis, Peter J Schatz: Use of modified tethers in screening compound libraries. Glaxo Group, Joe Liebeschuetz, Lauren L Stevens, September 28, 1999: US05958703 (161 worldwide citation)

The invention provides methods for screening libraries of complexes for compounds having a desired property, especially, the capacity to agonize, bind to, or antagonize a cellular receptor. The complexes in such libraries comprise a compound under test, a tag recording at least one step in synthesis ...


10
Stephen P A Fodor, Dennis W Solas, William J Dower: Arrays and methods for detecting nucleic acids. Affymetrix, Morgan Lewis & Bockius, June 10, 2003: US06576424 (150 worldwide citation)

The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and ...