1
Tom D Bennett, William J Combs, Kallok Michael J, Brian B Lee, Rahul Mehra, George J Klein: Subcutaneous multi-electrode sensing system, method and pacer. Medtronic, Reed A Duthler, Harold R Patton, July 26, 1994: US05331966 (887 worldwide citation)

A method and apparatus for providing an enhanced capability of detecting and gathering electrical cardiac signals via an array of relatively closely spaced subcutaneous electrodes (located on the body of an implanted device) which may be employed with suitable switching circuits, signal processors, ...


2
William J Combs, Catherine R Condie, Roy Martin, Dwight H Warkentin, John D Wahlstrandl: Impedance monitor for discerning edema through evaluation of respiratory rate. Medtronic, Harold R Patton, Michael B Atlass, September 28, 1999: US05957861 (442 worldwide citation)

An impedance monitor for discerning edema through evaluation of respiratory rate. Preferred embodiment includes edema monitor and trigger to initiate diagnostic reporting or corrective action when activated. Recording of Long Term Average and Short Term Average values for secondary edema measure bas ...


3
Todd J Sheldon, William J Combs, Mark K Erickson, Can Cinbis: Posture and device orientation and calibration for implantable medical devices. Medtronic, Harold R Patton, Reed A Duthler, March 28, 2000: US06044297 (395 worldwide citation)

A method of and apparatus for determining the physical posture of a patient's body, having a superior-inferior body axis, an anterior-posterior body axis and a lateral-medial body axis, in relation to earth's gravitational field. A medical device having first, second and, optionally, third accelerom ...


4
William J Combs, Catherine R Condie, Roy Martin, Dwight H Warkentin, John D Wahlstrand, David L Thompson, Li Wang: Implantable medical device for measuring time varying physiologic conditions especially edema and for responding thereto. Medtronic, Reed Duthler, January 28, 2003: US06512949 (314 worldwide citation)

An impedance monitor for discerning edema through evaluation of respiratory rate. Preferred embodiment includes edema monitor and trigger to initiate diagnostic reporting or corrective action when activated. Recording of Long Term Average and Short Term Average values for secondary edema measure bas ...


5
Barouh V Berkovits, Menashe B Waxman, William J Combs: Rate scanning demand pacemaker and method for treatment of tachycardia. Medtronic, Joseph F Breimayer, John L Rooney, Robert C Beck, March 25, 1986: US04577633 (165 worldwide citation)

A self-adapting demand pacemaker that recognizes the tachycardia from the intrinsic signals and initiates treatment in the following manner: First, the escape interval of the demand pacemaker is shortened to be identical to the cycle length of the tachycardia, then to overdrive the tachycardia the p ...


6
Weimin Sun, Pamela A Abshire, Eric J Panken, William J Combs: Adaptive and morphological system for discriminating P-waves and R-waves inside the human body. Medtronic, Thomas F Woods, Harold R Patton, May 26, 1998: US05755739 (162 worldwide citation)

The present invention is a method and apparatus for processing a sensed atrial electrogram in conjunction with a sensed ventricular electrogram. The present invention permits accurate discrimination of atrial P-waves from far field ventricular events such as far field R-waves and avoids oversensing ...


7
Charles G Yerich, William J Combs, Karen J Kleckner, Eric J Panken, Richard S Schallhorn, John D Wahlstrand: Method and apparatus for rate-responsive cardiac pacing. Medtronic, Michael B Atlass, Harold R Patton, October 8, 1996: US05562711 (159 worldwide citation)

A body-implantable rate-responsive cardiac pacemaker is provided with circuitry for sensing a plurality of physiologic parameters known to be indicative of a patient's metabolic demand for increased cardiac output. In one embodiment, a rate-responsive pacemaker is provided with an activity sensor fo ...


8
Weimin Sun, Eric J Panken, William J Combs: Method and apparatus for discriminating P and R waves. Medtronic, Thomas F Woods, Harold R Patton, July 14, 1998: US05778881 (151 worldwide citation)

This is a method and apparatus for the automated discrimination of cardiac events of interest, including P-waves, R-waves, T-waves, and specific arrhythmic sequences, in EGM signals for data storage in an implantable monitor or to control operations of an implantable cardiac stimulator through the u ...


9
William J Combs, Edwin G Duffin, T V Rao: Method and apparatus for treatment of atrial fibrillation. Medtronic, Reed A Duthler, Harold R Patton, October 7, 1997: US05674251 (144 worldwide citation)

A pacemaker system adapted to deliver pacing pulses in the presence of fibrillation. The pacing pulses are delivered via large surface area electrodes of the type normally used to accomplish defibrillation or cardioversion using high voltage pulses. An extended pulse train is delivered in order to g ...


10
Michael B Shelton, William J Combs, Tommy D Bennett, Michael R Tollinger, Kenneth M Riff: Rate responsive cardiac pacemaker and method for work-modulating pacing rate deceleration. Medtronic, Reed A Duthler, Harold R Patton, May 17, 1994: US05312453 (121 worldwide citation)

A rate-responsive cardiac pacemaker in which deceleration of the pacing rate is modulated according to recent patient activity or "work". Based on signals provided from an activity sensor in the pacemaker, the pacemaker maintains and periodically recomputes a work value corresponding to the amount o ...