1
Shmuel Cabilly, Herbert L Heyneker, William E Holmes, Arthur D Riggs, Ronald B Wetzel: Recombinant immunoglobin preparations. Genentech, March 28, 1989: US04816567 (2766 worldwide citation)

Altered and native immunoglobulins, including constant-variable region chimeras, are prepared in recombinant cell culture. The immunoglobulins contain variable regions which are immunologically capable of binding predetermined antigens. Methods are provided for refolding directly expressed immunoglo ...


2
Shmuel Cabilly, Herbert L Heyneker, William E Holmes, Arthur D Riggs, Ronald B Wetzel: Methods of producing immunoglobulins, vectors and transformed host cells for use therein. Genentech, Burns Doane Swecker & Mathis, December 18, 2001: US06331415 (344 worldwide citation)

The invention relates to processes for producing an immunoglobulin or an immunologically functional immunoglobulin fragment containing at least the variable domains of the immunoglobulin heavy and light chains. The processes can use one or more vectors which produce both the heavy and light chains o ...


3
Richard L Vandlen, William E Holmes: Structure, production and use of heregulin. Genentech, Wendy M Lee, November 22, 1994: US05367060 (85 worldwide citation)

A novel polypeptide with binding affinity for the p185.sup.HER2 receptor, designated heregulin-.alpha., has been identified and purified from cultured human cells. DNA sequences encoding additional heregulin polypeptides, designated heregulin-.alpha., heregulin-.beta.1, heregulin-.beta.2, heregulin- ...


4
Richard L Vandlen, William E Holmes: Method for purifying heregulin. Genentech, Wendy M Lee, June 24, 1997: US05641869 (73 worldwide citation)

A novel polypeptide with binding affinity for the p185.sup.HER2 receptor, designated heregulin-.alpha., has been identified and purified from cultured human cells. DNA sequences encoding additional heregulin polypeptides, designated heregulin-.alpha., heregulin-.beta.1, heregulin-.beta.2, heregulin- ...


5
Richard L Vandlen, William E Holmes: Nucleic acids, vectors and host cells encoding heregulin. Genentech, Wendy M Lee, November 24, 1998: US05840525 (54 worldwide citation)

A novel polypeptide with binding affinity for the p185.sup.HER2 receptor, designated heregulin-.alpha., has been identified and purified from cultured human cells. DNA sequences encoding additional heregulin polypeptides, designated heregulin-.alpha., heregulin-.beta.1, heregulin-.beta.2, heregulin- ...


6
Richard L Vandlen, William E Holmes: Nucleic acids vectors and host cells encoding and expressing heregulin 2-.alpha.. Genentech, Wendy M Lee, November 10, 1998: US05834229 (44 worldwide citation)

Novel 2 polypeptides with binding affinity for the p185.sup.HER2 receptor, designated heregulin 2-.alpha. and heregulin 2-.beta., have been identified and purified from human tissue. The cDNA encoding the novel heregulin 2-.alpha. has been isolated from human tissue and sequenced. Provided herein is ...


7
Richard L Vandlen, William E Holmes: Antibodies specific for heregulin 2-.alpha.. Genentech, Wendy M Lee, January 12, 1999: US05859206 (40 worldwide citation)

Novel polypeptides with binding affinity for the p185.sup.HER2 receptor, designated heregulin 2-.alpha. and heregulin 2-.beta., have been identified and purified from human tissue. The cDNA encoding the novel heregulin 2-.alpha. has been isolated from human tissue and sequenced. Provided herein is n ...


8
Richard L Vandlen, William E Holmes: Method of using HRG2-.alpha. to stimulate P185.sup.HeR2. Genentech, Wendy M Lee, January 5, 1999: US05856110 (32 worldwide citation)

Novel 2 polypeptides with binding affinity for the p185.sup.HER2 receptor, designated heregulin 2-.alpha. and heregulin 2-.beta., have been identified and purified from human tissue. The cDNA encoding the novel heregulin 2-.alpha. has been isolated from human tissue and sequenced. Provided herein is ...


9
Deborah L Higgins, William E Holmes, Adair J Hotchkiss: Processes for the preparation of t-PA mutants. Genentech, Walter H Dreger, June 19, 1990: US04935237 (29 worldwide citation)

Disclosed herein are improved processes for preparing variant human t-PA proteins exhibiting improved pharmacokinetic properties relative to natural t-PA. One such illustrated variant, devoid of amino acids corresponding to amino acids 1 through 44 of natural t-PA, is shown to exhibit a plasma half- ...


10
Arvin D McGregor, William E Holmes: Double read system for character recognition systems. Burroughs Corporation, G Gregory Schivley, Michael B McMurry, Edwin W Uren, February 10, 1976: US03938089 (16 worldwide citation)

An improved character reading system that utilizes two separate read devices: a first read device and a second read device in combination with a random access memory for storing each character read by the first read device, a memory control circuit for writing each character into the random access m ...