1
George T Gillies, John Kucharczyk, William C Broaddus, Richard Latchaw: MR-visible medical device for neurological interventions using nonlinear magnetic stereotaxis and a method imaging. The Regents of University of Minnesota, Virginia Commonwealth University, Mark A Litman & Assoc, August 7, 2001: US06272370 (227 worldwide citation)

The present invention comprises a device and method for targeted drug delivery, and especially intracranial inflsion or retroperfusion drug delivery using nonlinear magnetic stereotaxis in combination with magnetic resonance (MR) imaging and/or X-ray visualization. An MR-visible and/or X-ray visible ...


2
George T Gillies, Roger N Hastings, Jeffrey M Garibaldi, William C Broaddus: Catheter navigation within an MR imaging device. Stereotaxis, Harness Dickey & Pierce, December 21, 2004: US06834201 (127 worldwide citation)

A method of magnetically manipulating a medical device within a body part of a human patient in conjunction with MR imaging includes applying a navigating magnetic field with magnets from the MR imaging device, and changing the magnetic moment of the medical device to change the orientation of the m ...


3
John Kucharczyk, George T Gillies, William C Broaddus, Helen L Fillmore: Cell delivery catheter and method. Beck & Tysver P L L C, July 29, 2003: US06599274 (31 worldwide citation)

A cell delivery catheter having one of more apearutres is used to positon and deliver cells to an implant site in a patient.


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William C Broaddus, Zhi Jian Chen, George T Gillies: Coaxial catheter systems for transference of medium. University of Virginia Patent Foundation, Robert J Decker, June 1, 2010: US07727225 (11 worldwide citation)

A method, technique and system is disclosed for the delivery of therapeutic agents and/or into the bulk brain tissues and other parts, tissues and organs of the body, including vasculature. A novel form of coaxial catheter provides a means for implanting an outer tube into the brain, then inserting ...


6
Erhard Bieberich, Raphael M Ottenbrite, Robert K Yu, Helen Fillmore, William C Broaddus: Hydroxyalkyl amide analogs of ceramide. Virginia Commonwealth University, Whithan Curtis & Christofferson P C, June 25, 2002: US06410597 (6 worldwide citation)

The present invention provides methods for treating disease conditions associated with abnormal cellular proliferation, inflammation and viral infection or proliferation by the administration of ceramic analogs. The ceramic analogs appear to be specific for modulation of the enzyme PKC&zgr;.


7
William C Broaddus, Zhi Jian Chen, George T Gillies: Closure device for skull plates and related method thereof. University of Virginia Patent Foundation, Robert J Decker, July 24, 2012: US08226694 (2 worldwide citation)

A method and means of cranial bone flap fixation that provides, among other things, the re-opening, resetting and/or repositioning of the bone flap during neurosurgical procedures. The instrumentation central to this method and means is MR and CT-visible to aid in imaging-based localization of it. T ...


8
William C Broaddus, Zhi Jian Chen, George T Gillies: Coaxial catheter systems for transference of medium. University of Virginia Patent Foundation, Virginia Commonwealth University Intellectual Property Foundation, Robert J Decker, Kilpatrick Townsend & Stockton, July 3, 2012: US08211083 (2 worldwide citation)

A method, technique and system is disclosed for the delivery of therapeutic agents and/or into the bulk brain tissues and other parts, tissues and organs of the body, including vasculature. A novel form of coaxial catheter provides a means for implanting an outer tube into the brain, then inserting ...


9
John Kucharczyk, George T Gillies, William C Broaddus, Helen L Fillmore: Cell delivery catheter and method. Mark A Litman & Associates P A, January 17, 2012: US08096984 (1 worldwide citation)

A cell delivery catheter having one of more apearutres is used to positon and deliver cells to an implant site in a patient.


10
William C Broaddus, Rahul Mahajan, George T Gillies: System and method for intracranial implantation of therapeutic or diagnostic agents. University of Virginia Patent Foundation, Virginia Commonwealth University, Robert J Decker, Tanner IP PLLC, June 6, 2017: US09669198

A system and related method for delivering the anti-tumoral agent carmustine or other types of diagnostic or therapeutic agents into the brain of a patient with a brain tumor includes an insertion device, a skull mount, and a reformulated geometry of the carmustine compound (or other material) optim ...



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