Frederik H M Wittkampf, Willem Boute: Pacemaker system with automatic event-programmed switching between unipolar and bipolar operation. Vitafin, Woodcock Washburn Kurtz Mackiewicz & Norris, October 29, 1985: US04549548 (145 worldwide citation)

A pacemaker system incorporates an implantable pacemaker and a plurality of electrodes, electrodes preferably being on a pacing lead for a single chamber pacemaker, or a pair of such leads for a dual chamber pacemaker. Programmable connection means are provided for connecting the pacemaker output to ...

Willem Boute: Dual chamber pacing system and method utilizing detection of ventricular fusion for adjustment of the atrial-ventricular delay as therapy for hypertrophic obstructive cardiomyopathy. Vitatron Medical, Woodcock Washburn Kurtz Mackiewicz & Norris, July 9, 1996: US05534016 (115 worldwide citation)

A dual chamber pacemaker for providing ventricular pace pulses synchronized with atrial senses or paces, and having specific control for optimizing the AV escape interval and resultant AV delay for purposes of therapy for a patient with hypertrophic obstructive cardiomyopathy (HOCM). The pacemaker h ...

Willem Boute: Dual chamber pacemaker with automatically optimized AV delay. Vitatron Medical, Woodcock Washburn Kurtz Mackiewicz & Norris, July 19, 1994: US05330511 (100 worldwide citation)

The dual chamber system and method of operation contains an automatic test for determining an optimum AV interval at a test frequency such as LRL. In a preferred embodiment the test is carried out at nighttime, wherein the implanted pacer is set to asynchronous operation at LRL, and AV interval is s ...

Willem Boute, Frederik H M Wittkampf, Gerrit W van Arragon, Kornelis A Mensink: Programmable cardiac pacemaker with microprocessor control of pacer rate. Vitatron Medical, Woodcock Washburn Kurtz Mackiewicz & Norris, March 12, 1985: US04503857 (92 worldwide citation)

A programmable pacemaker apparatus having a microprocessor and means for receiving program information from an external source, means for generating and delivering stimulus signals and means for sensing the occurrence of natural heartbeats in a patient, and having a battery source powering the appar ...

Willem Boute: Cardiac treatment system and method for sensing and responding to heart failure. Vitatron Medical, Thomas F Woods, Michael J Jaro, Harold Patton, October 10, 2000: US06129744 (83 worldwide citation)

A pacing system and method for determining a heart failure condition such as left ventricular dysfunction in a patient are provided, based upon obtaining information from cardiac signals, which information is processed and examined for an indication of the onset or progression of LVD. Since LVD is g ...

Malcolm J S Begemann, Willem Boute, Marijn van Gemert: Pacemaker with improved dynamic rate responsiveness. Vitatron Medical, Woodcock Washburn Kurtz Mackiewicz & Norris, November 27, 1990: US04972834 (75 worldwide citation)

A rate adaptive pacemaker system, and method of operation, is provided which has a pacemaker which generates pacing pulses at a controlled pacing rate as a function of at least one monitored patient variable. The correlation of pacing rate with the patient variable is nonlinear, or dynamic, and is a ...

Willem Boute, Harm H Van Bolhuis: Method and system for stimulating a mammalian heart. Medtronic, Thomas F Woods, Thomas G Berry, August 27, 2002: US06442427 (53 worldwide citation)

A method for instantaneously stimulating a mammalian heart is provided. The mammalian heart includes a first atrium and a second atrium. A commencement signal is received. At least one additional signal is received. A plurality of intervals corresponding to the time between two successive signals is ...

Bert A Albers, Willem Boute: Method and system for operating an implantable medical device. Medtronic, Thomas F Woods, Thomas G Berry, September 10, 2002: US06449510 (40 worldwide citation)

A method of operating an implantable medical device is provided. A plurality of atrio-ventricular (AV) measurement signals is received. A QT interval is determined. The QT interval is a function of the AV measurement signals. Each of the plurality of AV measurement signals is compared with the QT in ...

Frederik H M Wittkampf, Willem Boute: Dual chamber pacemaker system with V-A time measurement apparatus and method. Vitafin, Woodcock Washburn Kurtz Mackiewicz & Norris, May 7, 1985: US04515161 (37 worldwide citation)

A dual chamber pacemaker having means for operating in different pacing modes, including dual chamber modes, contains the capability of switching into a fixed rate ventricular pacing mode and of sensing early atrial signals without affecting the ventricular pacing timing. The timing of a plurality o ...

Willem Boute, Jos W Van Hove: Implantable medical device with ventricular pacing protocol. Medtronic, Daniel G Chapik, October 16, 2007: US07283872 (36 worldwide citation)

An implantable medical device operates to promote intrinsic ventricular depolarization according to a pacing protocol. The medical device monitors the AV interval and adjusts the Ventricular Pacing Protocol if the AV interval exceeds a threshold when the cardiac rate is elevated.