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Cook Michael Allen, Wilkins Robert Bennett: Preparation or purification of clavulanic acid or its salts or esters. Smithkline Beecham, September 6, 1995: GB2287025-A (2 worldwide citation)

A process for the preparation and/or purification of clavulanic acid or a pharmaceutically acceptable salt or ester thereof comprises i) contacting impure clavulanic acid or a labile derivative or an alkali metal salt thereof in an organic solvent, with tertiary octylamine; ii) isolating the tertiar ...


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Cook Michael Allen, Wilkins Robert Bennett: Process for the preparation of clavulanic acid. Smithkline Beecham, April 19, 1995: GB2282810-A (1 worldwide citation)

A process for the preparation of clavulanic acid or its pharmaceutically acceptable salts and esters in which an amine of formula (II) is used as an intermediate to form a salt with clavulanic acid, R1, R2 and R3 being selected from various substituent atoms and groups.


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Cook Michael Allen, Wilkins Robert Bennett: Process for the preparation of clavulanic acid.. Smithkline Beecham, September 20, 1995: EP0672669-A1 (1 worldwide citation)

A process for the preparation and/or purification of clavulanic acid or a pharmaceutically acceptable salt thereof comprises i) contacting impure clavulanic acid or an alkali metal salt thereof in an organic solvent, with tertiary octylamine; ii) isolating the tertiary-octylamine salt of clavulanic ...


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Cook Michael Allen, Wilkins Robert Bennett: Polyamine salts of clavulanic acid. Smithkline Beecham, December 11, 1996: EP0747383-A2

A process for the preparation of clavulanic acid or its pharmaceutically acceptable salts and esters in which an amine of formula (II): is used as an intermediate to form a salt with clavulanic acid, R1, R2 and R3 being selected from various substituent atoms and groups.


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Cook Michael Allen, Wilkins Robert Bennett: Process for the preparation and/or purification of clavulanic acid. Smithkline Beecham, March 6, 1996: EP0699682-A1

A process for the preparation of clavulanic acid or its pharmaceutically acceptable salts and esters in which an amine of formula (II): is used as an intermediate to form a salt with clavulanic acid, R1, R2 and R3 being selected from various substituent atoms and groups.


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Cook Michael Allen, Wilkins Robert Bennett: Process for the preparation of clavulanic acid.. Smithkline Beecham, September 20, 1995: EP0672670-A1

A process for the preparation of clavulanic acid or its pharmaceutically acceptable salts and esters in which an amine of formula (II): is used as an intermediate to form a salt with clavulanic acid, R1, R2 and R3 being selected from various substituent atoms and groups.


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