1

2

3
Barbosa Antonio J M Jr, Goldberg Daniel R, Hammach Abdelhakim, Liu Pingrong, Moss Neil, Ralph Mark Stephen, Roth Gregory Paul, Sarko Christopher Ronald, Soleymanzadeh Fariba, White Andre: Benzimidazolones and their use as cytokine inhibitors. Boehringer Ingelheim Pharma, June 15, 2005: EP1539708-A1

Disclosed are benzimidazolone compounds of formulas (II) wherein X is O, S or NR5. The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also ...


4
Bentzien Joerg Martin, Farmer Bennett Ii, Pullen Steven S, Studts Joey Martin, White Andre: (itk) Kinase domain. Boehringer Ingelheim Pharmaceuticals, Bentzien Joerg Martin, Farmer Bennett Ii, Pullen Steven S, Studts Joey Martin, White Andre, MORRIS Michael P, July 21, 2005: WO/2005/066335

Disclosed are polypeptides encoding the ITK kinase domain and nucleic acids encoding such polypeptides, crystal structures of various polypeptide-ligand complexes comprising the ITK kinase domain bound to a ligand, methods of producing the aforementioned polypeptides and nucleic acids which encode t ...


5
Barbosa Antonio Jm Jr, Goldberg Daniel R, Hammach Abdelhakim, Liu Pingrong, Moss Neil, Ralph Mark Stephen, Roth Gregory Paul, Sarko Christopher Ronald, Soleymanzadeh Fariba, White Andre: Benzimidazolones and their use as cytokine inhibitors. Boehringer Ingelheim Pharmaceuticals, RAYMOND Robert P, March 25, 2004: WO/2004/024699

Disclosed are benzimidazolone compounds of formulas (II) wherein X is O, S or NR5. The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also ...