1
Widder Kenneth J, Westkaemper Peter J: Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production.. Molecular Biosystems, July 26, 1989: EP0324938-A1 (198 worldwide citation)

A microbubble-type ultrasonic imaging agent is provided comprising a parenterally-administerable aqueous medium containing a dispersion of microspheres predominantly of diameters less than 10 microns, wherein the microspheres consist of gas microbubbles encapsulated with water-insolubilized biocompa ...


2
Cerny David, Mills Gary J, Westkaemper Peter J: Continuous sonication method for preparing protein encapsulated microbubbles.. Molecular Biosystems, March 21, 1990: EP0359246-A2 (106 worldwide citation)

An ultrasonic imaging agent is produced by a continuous sonication processing of an aqueous solution of heat-denaturable biocompatible protein. The solution is carefully preheated to a temperature of incipient protein denaturation without forming insolubilized protein. A gaseous fluid, preferably ai ...


3
Cerny David, Mills Gary J, Westkaemper Peter J: Sonification en continu pour la preparation de microbulles encapsulees de proteines, Continuous sonication method for preparing protein encapsulated microbubbles. Molecular Biosystems, BORDEN LADNER GERVAIS, October 10, 1995: CA1337286

An ultrasonic imaging agent is produced by acontinuous sonication processing of an aqueous solutionof heat-denaturable biocompatible protein. The solutionis carefully preheated to a temperature of incipientprotein denaturation without forming insolubilized pro-tein. A gaseous fluid, preferably air, ...