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Wen Hai Bo, Li Panjian, Smith Todd: Metallic implants having roughened surfaces and methods for producing the same. Depuy Products, August 25, 2004: EP1449544-A1 (48 worldwide citation)

The invention provides a method of providing a metallic orthopaedic implant with a micron or nanometer-scale surface roughness to facilitate acceptance of tissue and bone growth or apposition after implantation while maintaining the structural integrity of the orthopaedic implant. The invention also ...


2
Leitao Eugenia Ribeiro de Sous, de Bruijn Joost Dick, Wen Hai Bo, de Groot Klaas: Device for incorporation and release of biologically active agents. Matrix Medical, November 12, 1997: EP0806212-A1 (41 worldwide citation)

The invention provides an implantable device coated with a layer of calcium phosphate and optionally one or more biologically active substances such as growth factors, lipis, (lipo)polysaccharides, hormones, proteins, antibiotics or cytostatics. The device can be obtained by a nanotechnology process ...


3
Li Panjian, Wen Hai Bo, Hippensteel Elizabeth A: Biological agent-containing ceramic coating and method. Depuy Products, August 4, 2004: EP1442755-A1 (3 worldwide citation)

An implantable article comprises a biocompatible substrate and a bioactive ceramic surface coating into which a biological agent is incorporated. The preparation and modification of an implantable article involve incubating a biocompatible substrate surface or pre-existing ceramic coating thereon wi ...


4
Wen Hai Bo, Li Panjian, Smith Todd: Metal implant having rough surface and method for manufacturing the same. Depuy Products, September 16, 2004: JP2004-255183 (1 worldwide citation)

PROBLEM TO BE SOLVED: To provide a method for forming a rough surface on an implant having a sophisticated surface geometry in order to promote integration of the implant with the bones.SOLUTION: The method comprises a step for preparing an orthopedic metal implant which comprises a metal body havin ...


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AKELLA Rama, GARRETT Ian Ross, WEN Hai Bo, LI Shuliang, ACKER Dean M, WILHELM Nichole: SUBSTANCES DE REMPLISSAGE DE VIDES OSSEUX, BONE VOID FILLERS. ZIMMER ORTHOBIOLOGICS, AKELLA Rama, GARRETT Ian Ross, WEN Hai Bo, LI Shuliang, ACKER Dean M, WILHELM Nichole, PERDOK SHONKA Monique M, May 24, 2012: WO/2012/068135

A bone void filler composition containing an acidic mineral component that contains a calcium source and a phosphate source or a lower alkyl carboxylate source; an osteoinductive component that contains demineralized bone; and a three-dimensional, osteoconductive biologically acceptable carrier comp ...


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Li Panjian, Hippensteel Elizabeth, Wen Hai Bo: Device for applying biomimetic coating on medical implant. Depuy Products, September 22, 2005: JP2005-253968

PROBLEM TO BE SOLVED: To provide an improved device capable of applying a variation-free uniform coating on an implant.SOLUTION: The device for applying a biomimetic coating on a product for implant includes an external reactor containing a biomimetic coating liquid and an internal reactor arranged ...


7
Li Panjian, Wen Hai Bo, Hippensteel Elizabeth A: Biological agent containing ceramic coating and method. Depuy Products, August 19, 2004: JP2004-230174

PROBLEM TO BE SOLVED: To provide an implantable article having improved bioactive ceramic coating of high reliability, and a method of preparing the same.SOLUTION: The implantable article has a biocompatible substarate and a bioactive ceramic surface coating into which a biological agent is incorpor ...


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GARRETT IAN ROSS, WEN HAI BO, LI SHULIANG, ACKER DEAN M, WILHELM NICHOLE, AKELLA RAMA: SUBSTANCES DE REMPLISSAGE DE VIDES OSSEUX, BONE VOID FILLERS. ZIMMER ORTHOBIOLOGICS, ZIMMER ORTHOBIOLOGICS, NORTON ROSE FULBRIGHT CANADA S E N C R L S R L, January 2, 2018: CA2817584

A bone void filler composition containing an acidic mineral component that contains a calcium source and a phosphate source or a lower alkyl carboxylate source; an osteoinductive component that contains demineralized bone; and a three-dimensional, osteoconductive biologically acceptable carrier comp ...