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Meyer Harry M Jr, Weiss Martin J: Suppression of b-cells in mammals.. American Cyanamid Co, September 20, 1989: EP0332865-A2 (106 worldwide citation)

Selective suppression of B-lymphocytes in mammals is accomplished by treatment with an adequate amount of antibody to a mature B-lymphocyte surface marker.


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Hamann Philip Ross, Hinman Lois, Hollander Irwin, Holcomb Ryan, Tsou Hwei Ru, Hallett William, Weiss Martin J: Conjugates of methyltrithio antitumor agents and intermediates for their synthesis. American Cyanamid Co, January 3, 1996: EP0689845-A2 (14 worldwide citation)

This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, o ...


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Floyd Middleton B Jr, Weiss Martin J, Grudzinskas Charles V, Chen Sow Mei L: Acides 15-desoxy-16-hydroxy-prostanoiques substitues en 16 et congeneres, 15-deoxy-16-hydroxy-16-substituted prostanoic acids and congeners. American Cyanamid Company, SMART & BIGGAR, September 4, 1984: CA1173826

26,21 ABSTRACT OF THE DISCLOSURE This disclosure describes novel 15-deoxy-16- -hydroxy-16-substituted prostanoic acids and congenersthereof having utility as brochodilators as hypotensiveagents, and as agents for the control of excessive gastricsecretion.


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Weiss Martin J, Schaub Robert E, Mcgahren William J, Floyd Middleton B: Derives de lacide hydroxy-9 trans-13 prostenoique, Derivatives of 9-hydroxy-13-trans-prostenoic acid. American Cyanamid Company, December 26, 1978: CA1045131

A B S T R A C THydroxy substituted 15-deoxy prostanoic acids and derivatives there-of, having the general formula Imagewherein R1, R2, R3, Y and Z are as defined herein, and their pharmaceuticallyacceptable salts, constitute a new series of compounds related to the prostag-landins and possessing man ...


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Bernady Karel F, Floyd Middleton B, Poletto John F, Schaub Robert E, Weiss Martin J: (Carboxy-6 cis hexenyl-2)-2 hydroxy-4 cyclopent-2 en-1 one et derives, 2-(6-carboxy-2-cis-hexenyl)-4-hydroxycyclopent-2-en-1-one and derivatives thereof. American Cyanamid Company, February 20, 1979: CA1049022

ABSTRACT OF THE DISCLOSURE Novel 4-hydroxy-cyclopentenone derivatives of the generalformula Imagewherein p is from 3 to 5 and J is hydrogen, tetrahydropyranyl or tri-lower alkylsilyl, are prostaglandin intermediates and are prepared byreacting the corresponding free carboxylic acid derivative of 3,4 ...


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