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Casarez Anthony, Chaudhary Kleem, Cho Aesop, Clarke Michael, Doerffler Edward, Fardis Maria, Kim Choung U, Pyun Hyungjung, Sheng Xiaoning C, Wang Jianying: Antiviral phosphinate compounds. Gilead Sciences, Casarez Anthony, Chaudhary Kleem, Cho Aesop, Clarke Michael, Doerffler Edward, Fardis Maria, Kim Choung U, Pyun Hyungjung, Sheng Xiaoning C, Wang Jianying, KUTZENCO Allan N, January 10, 2008: WO/2008/005565 (19 worldwide citation)

The invention is related to anti-viral phosphinate compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.


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Arimilli Murty N, Becker Mark M, Birkus Gabriel, Bryant Clifford, Chen James M, Chen Xiaowu, Cihlar Tomas, Dastgah Azar, Eisenberg Eugene J, Fardis Maria, Hatada Marcos, He Gong Xin, Jin Haolun, Kim Choung U, Lee William A, Lee Christopher P, Lin Kuei Ying, Liu Hongtao, Mackman Richard L, Mcdermott Martin J, Mitchell Michael L, Nelson Peter H, Pyun Hyung Jung, Rowe Tanisha D, Sparacino Mark, Swaminathan Sundaramoorthi, Tario James D, Wang Jianying, Williams Matthew A, Xu Lianhong, Yang Zheng Yu, Yu Richard H, Zhang Jiancun, Zhang Lijun: Method and compositions for identifying anti-hiv therapeutic compounds. Gilead Sciences, Arimilli Murty N, Becker Mark M, Birkus Gabriel, Bryant Clifford, Chen James M, Chen Xiaowu, Cihlar Tomas, Dastgah Azar, Eisenberg Eugene J, Fardis Maria, Hatada Marcos, He Gong Xin, Jin Haolun, Kim Choung U, Lee William A, Lee Christopher P, Lin Kuei Ying, Liu Hongtao, Mackman Richard L, Mcdermott Martin J, Mitchell Michael L, Nelson Peter H, Pyun Hyung Jung, Rowe Tanisha D, Sparacino Mark, Swaminathan Sundaramoorthi, Tario James D, Wang Jianying, Williams Matthew A, Xu Lianhong, Yang Zheng Yu, Yu Richard H, Zhang Jiancun, Zhang Lijun, MARSH David R, July 14, 2005: WO/2005/064008 (6 worldwide citation)

Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are p ...


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Bender Steven Lee, Casperson Gerald Fries, Hu Lowe Dana Dan, Jiang Xin, Li Gang, North Michael Aidan, Wang Jianying, Wickman Grant, Brams Peter, Huang Haichun, Devaux Brigitte, Chen Haibin, Tanamachi Dawn M, Toy Kristopher, Yang Lan, Sproul Tim W, Yamanaka Mark: Alpha 5 - beta 1 antibodies and their uses. Medarex, Pfizer, Bender Steven Lee, Casperson Gerald Fries, Hu Lowe Dana Dan, Jiang Xin, Li Gang, North Michael Aidan, Wang Jianying, Wickman Grant, Brams Peter, Huang Haichun, Devaux Brigitte, Chen Haibin, Tanamachi Dawn M, Toy Kristopher, Yang Lan, Sproul Tim W, Yamanaka Mark, BRADY James W, August 13, 2009: WO/2009/100110 (5 worldwide citation)

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin α5β1 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells ...


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Sankaravadivelu Srinivasa M, Mail Scott Mitchel, Wang Jianying, Fuelling Sarah: Enhanced windows management feature. Microsoft Corporation, May 15, 2008: WO/2008/058042 (3 worldwide citation)

An enhanced windows management feature provides computing device users with the ability to view open windows simultaneously and unobscured on the computing device display. User satisfaction is increased when a user can cause all windows open on a computing device display to be exhibited simultaneous ...


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MITCHUM Melissa G, REPLOGLE Amy, WANG Jianying, WANG Xiaohong, CHEN Shiyan, LANG Ping, DAVIS Eric L, BAUM Thomas J, HUSSEY Richard S: Cultures résistantes aux nématodes, Nematode resistant crops. The Curators Of The University Of Missouri, Cornell Research Foundation, North Carolina State University, Iowa State University Research Foundation, University Of Georgia Research Foundation, MITCHUM Melissa G, REPLOGLE Amy, WANG Jianying, WANG Xiaohong, CHEN Shiyan, LANG Ping, DAVIS Eric L, BAUM Thomas J, HUSSEY Richard S, ROMANO Charles P, February 9, 2012: WO/2012/018489 (1 worldwide citation)

Methods of inhibiting plant parasitic nematodes, methods of obtaining transgenic plants useful for inhibiting such nematodes, and transgenic plants that are resistant to plant parasitic nematodes through inhibition of plant nematode CLE peptide receptor genes are provided. Methods for expressing gen ...


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Cheng Xiaoqin, Cook Gary P, Desai Manoj C, Doerffler Edward, He Gong Xin, Kim Choung U, Lee William A, Rohloff John C, Wang Jianying, Yang Zheng Yu: Anti-proliferative compounds, compositions, and methods of use thereof. Gilead Sciences, Cheng Xiaoqin, Cook Gary P, Desai Manoj C, Doerffler Edward, He Gong Xin, Kim Choung U, Lee William A, Rohloff John C, Wang Jianying, Yang Zheng Yu, KUTZENCO Allan N, January 4, 2007: WO/2007/002912 (1 worldwide citation)

Compounds and compositions of Formula I are described, useful as anti-proliferative agents, and in particular anti-HPV, wherein: Y1A and Y1B are independently Y1; RX1 is RX; RX2 is alkenyl of 2 to 18 carbon atoms or alkynyl of 2 to 18 carbon atoms; Y1 is = O, -O(RX), =S, -N(RX), -N(O)(RX), -N(ORX), ...


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NORTH MICHAEL AIDAN, WANG JIANYING, WICKMAN GRANT RAYMOND, ZHANG JINGCHUAN, AMUNDSON KARIN KRISTINA, BEDIAN VAHE, BELOUSKI SHELLEY SIMS, HU LOWE DANA DAN, JIANG XIN, KARLICEK SHANNON MARIE, KELLERMANN SIRID AIMEE, THOMSON JAMES ARTHUR: Human monoclonal antibodies to activin receptor-like kinase-1 (ALK-1), Humane monoklonale Antikörper gegen activinrezeptorähnliche Kinase-1 (ALK-1), Anticorps monoclonaux humains dirigés contre la kinase-1 du type du récepteur dactivine (ALK-1). AMGEN FREMONT, Pfizer, May 2, 2012: EP2447283-A2

The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular doman (ECD) of activin receptor-like kinase-1 (ALK-1) and that function to abrogate the ALK-1/TGF-beta-1/Smad1 signaling pathway. The invention also relates to h ...


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