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Ledeboer Mark, Wang Jian, Moon Young Choom: Imidazoles, oxazoles and thiazoles with protein kinase inhibiting activities. Vertex Pharmaceuticals Incorporated, Ledeboer Mark, Wang Jian, Moon Young Choom, HALEY James F Jr, January 15, 2004: WO/2004/005283 (67 worldwide citation)

The present invention provides compounds of formula I: (I) or a pharmaceutically acceptable derivative thereof, wherein R1, R2, A, G, and W are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian protein kinase involved cel ...


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Farmer Luc, Martinez Botella Gabriel, Pierce Albert, Salituro Francesco, Wang Jian, Wannamker Marion, Wang Tiansheng: Azaindoles useful as inhibitors of janus kinases. Vertex Pharmaceuticals Incorporated, Farmer Luc, Martinez Botella Gabriel, Pierce Albert, Salituro Francesco, Wang Jian, Wannamker Marion, Wang Tiansheng, BROWN Karen E, July 26, 2007: WO/2007/084557 (51 worldwide citation)

The present invention relates to azaindole compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, ...


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Arnost Michael J, Bemis Guy W, Davies Robert J, Forster Cornelia J, Grey Ronald Jr, Ledford Brian, Marhefka Craig, Messersmith David, Pierce Albert C, Salituro Francesco, Wang Jian: Aminotriazole compounds useful as inhibitors of protein kinases. Vertex Pharmaceuticals Incorporated, Arnost Michael J, Bemis Guy W, Davies Robert J, Forster Cornelia J, Grey Ronald Jr, Ledeboer Mark W, Ledford Brian, Marhefka Craig, Messersmith David, Pierce Albert C, Salituro Francesco, Wang Jian, HALEY James F Jr, February 17, 2005: WO/2005/013982 (50 worldwide citation)

The present invention relates to aminotriazole compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention, processes for preparing the compounds and methods of using the compositions in the treatment of various ...


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Ledeboer Mark W, Pierce Albert C, Bemis Guy W, Farmer Luc J, Wang Tiansheng, Messersmith David, Duffy John P, Wang Jian, Salituro Francesco G: Pyrrolopyrimidines useful as inhibitors of protein kinase. Vertex Pharmaceuticals Incorporated, Ledeboer Mark W, Pierce Albert C, Bemis Guy W, Farmer Luc J, Wang Tiansheng, Messersmith David, Duffy John P, Wang Jian, Salituro Francesco G, BROWN Karen E, September 14, 2006: WO/2006/096270 (50 worldwide citation)

The present invention relates to compounds of formula (I) useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.


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Salituro Francesco, Farmer Luc, Wang Tiansheng, Wang Jian, Bethiel Randy, Wannamaker Marion, Martinez Botella Gabriel, Duffy John, Aronov Alexander, Lauffer David, Pierce Albert: Deazapurines useful as inhibitors of janus kinases. Vertex Pharmaceuticals Incorporated, Salituro Francesco, Farmer Luc, Wang Tiansheng, Wang Jian, Bethiel Randy, Wannamaker Marion, Martinez Botella Gabriel, Duffy John, Aronov Alexander, Lauffer David, Pierce Albert, BROWN Karen E, April 12, 2007: WO/2007/041130 (45 worldwide citation)

The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions ...


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Brenchley Guy, Farmer Luc J, Harrington Edmund Martin, Knegtel Ronald, O Donnell Michael, Salituro Francesco G, Studley John R, Wang Jian: Thiazoles useful as inhibitors of protein kinases. Vertex Pharmaceuticals Incorporated, Brenchley Guy, Farmer Luc J, Harrington Edmund Martin, Knegtel Ronald, O Donnell Michael, Salituro Francesco G, Studley John R, Wang Jian, SHAIR Karoline K M, October 14, 2004: WO/2004/087699 (31 worldwide citation)

The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. These compounds have ...


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Davies Robert J, Forster Cornelia J, Arnost Michael J, Wang Jian: Triazoles useful as inhibitors of protein kinases. Vertex Pharmaceuticals Incorporated, Davies Robert J, Forster Cornelia J, Arnost Michael J, Wang Jian, BROWN Karen E, May 4, 2006: WO/2006/047256 (25 worldwide citation)

The present invention relates to inhibitors of proteins kinases of formula (I). The invention also provides pharmaceuticals compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.



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