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Bankston Donald, Nagarathnam Dhanaphalan, Asgari Davoud, Shao Jianxing, Liu Xiao Gao, Khire Uday, Wang Chunguang, Hart Barry, Boyer Stephen, Weber Olaf, Lynch Mark: Process for preparing quinazoline rho-kinase inhibitors and intermediates thereof. Bayer Pharmaceuticals Corporation, Bankston Donald, Nagarathnam Dhanaphalan, Asgari Davoud, Shao Jianxing, Liu Xiao Gao, Khire Uday, Wang Chunguang, Hart Barry, Boyer Stephen, Weber Olaf, Lynch Mark, SHUBIN Harry B, April 8, 2004: WO/2004/029045 (24 worldwide citation)

The present invention relates to methods of producing quinazoline compounds (I) and derivatives thereof which are useful as Rho-kinase Inhibitors or intermediates thereof (3). Rho-kinase inhibitors are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications ...


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Nagarathnam Dhanapalan, Dumas Jacques, Hatoum Mokdad Holia, Boyer Stephen, Wang Chunguang, Pluempe Hans, Feurer Achim, Bennabi Samir: Pyrimidine derivatives as rho-kinase inhibitors. Bayer Pharmaceuticals Corporation, Nagarathnam Dhanapalan, Dumas Jacques, Hatoum Mokdad Holia, Boyer Stephen, Wang Chunguang, Pluempe Hans, Feurer Achim, Bennabi Samir, SHUBIN Harry B, July 31, 2003: WO/2003/062225 (2 worldwide citation)

Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.


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Nagarathnam Dhanapalan, Asgari Davoud, Shao Jianxing, Liu Xiao Gao, Khire Uday, Wang Chunguang, Hart Barry, Boyer Stephen, Weber Olaf, Lynch Mark, Bankston Donald: Rho-kinase inhibitors. Bayer Corporation, Nagarathnam Dhanapalan, Asgari Davoud, Shao Jianxing, Liu Xiao Gao, Khire Uday, Wang Chunguang, Hart Barry, Boyer Stephen, Weber Olaf, Lynch Mark, Bankston Donald, SHUBIN Harry B, October 3, 2002: WO/2002/076976 (1 worldwide citation)

Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart diseas ...


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Nagarathnam Dhanapalan, Khire Uday, Asgari Davoud, Shao Jianxing, Liu Xiao Gao, Wang Chunguang, Hart Barry, Weber Olaf, Lynch Mark, Zhang Lei, Wang Lei: Roh−kinase inhibitors. Bayer Healthcare, Nagarathnam Dhanapalan, Khire Uday, Asgari Davoud, Shao Jianxing, Liu Xiao Gao, Wang Chunguang, Hart Barry, Weber Olaf, Lynch Mark, Zhang Lei, Wang Lei, HARRY B Subin, July 24, 2003: WO/2003/059913 (1 worldwide citation)

Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho−kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho−kinase, e.g., coronary heart diseas ...


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Bankston Donald, Nagarathnam Dhanaphalan, Asgari Davoud, Shao Jianxing, Liu Xiao Gao, Khire Uday, Wang Chunguang, Hart Barry, Boyer Stephen, Weber Olaf, Lynch Mark: Process for preparing quinazoline rho-kinase inhibitors and intermediates thereof. Bayer, August 6, 2008: EP1953152-A1

The present invention relates to methods of producing quinazoline compounds and derivatives thereof which are useful as Rho-kinase Inhibitors or intermediates thereof. Rho-kinase inhibitors are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated ...


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