1
Donna R Cody, Sheila H H DeWitt, John C Hodges, John S Kiely, Walter H Moos, Michael R Pavia, Bruce D Roth, Mel C Schroeder, Charles J Stankovic: Apparatus for multiple simultaneous synthesis. Warner Lambert Company, Charles W Almer III, Francis J Tinney, June 28, 1994: US05324483 (194 worldwide citation)

An apparatus and method which provides a suitable location for multiple, simultaneous synthesis of compounds. The apparatus consists of: a reservoir block having a plurality of wells; a plurality of reaction tubes, usually gas dispersion tubes, having filters on their lower ends; a holder block, hav ...


2
Stephen C Bergmeier, David A Downs, Walter H Moos, David W Moreland, Haile Tecle: O-substituted tetrahydropyridine oxime cholinergic agents. Warner Lambert Company, Jerry F Janssen, December 1, 1987: US04710508 (44 worldwide citation)

Certain O-substituted 1-(1,2,3,6-tetrahydro-1-methyl-3-pyridinyl)ketone oximes and O-substituted 1-(1,2,3,6-tetrahydro-4-pyridinyl)ketone oximes are useful as analgesic agents or agents for the treatment or amelioration of the symptoms of cerebral insufficiency characterized by decreased central ace ...


3
Walter H Moos, Anthony J Thomas: Method of treating the symptoms of senile cognitive decline employing di- or trisubstituted urea cholinergic agents. Warner Lambert Company, Ronald A Daignault, January 10, 1989: US04797419 (29 worldwide citation)

Certain trisubstituted alkyl, aryl, pyridinyl, piperidinyl, and piperazinyl urea compounds stimulate the release of acetylcholine and are thus useful agents for the treatment of senile cognitive decline characterized by decreased cerebral acetylcholine production or release.


4
Donna R Cody, Sheila H H DeWitt, John C Hodges, John S Kiely, Walter H Moos, Michael R Pavia, Bruce D Roth, Mel C Schroeder, Charles J Stankovic: Apparatus and method for multiple simultaneous synthesis. Warner Lambert Company, Francis J Tinney, Charles W Almer III, March 18, 1997: US05612002 (24 worldwide citation)

A method for the multiple, simultaneous synthesis of compounds comprising the steps of: 1) providing an apparatus comprising a plurality of reaction tubes having filter members on their lower ends, a reservoir member for receiving the filter member, a holder member having a plurality of apertures fo ...


5
Linda L Coughenour, Robert E Davis, David A Downs, Thomas G Heffner, Leonard T Meltzer, Walter H Moos, David W Moreland, Haile Tecle: Tetrahydropyridine oxime compounds. Warner Lambert Company, Ruth H Newtson, May 29, 1990: US04929734 (24 worldwide citation)

Certain N-substituted 1-(1,2,3,6-tetrahydro-3-pyridinyl)oximes and N-substituted 1-(1,2,3,6-tetrahydro-4-pyridinyl)oximes are useful as sigma binding agents for the treatment of depression, psychoses and/or inflammatory diseases.


6
Stephen C Bergmeier, David A Downs, Walter H Moos, David W Moreland, Haile Tecle: O-substituted tetrahydropyridine oxime cholinergic agents. Warner Lambert Company, Jerry F Janssen, November 22, 1988: US04786648 (23 worldwide citation)

Certain O-substituted-1,2,5,6-tetrahydro-3- or 1,2,3,6-tetrahydro-4-pyridine oximes are useful as agents for treating pain or for treating the symptoms of senile cognitive decline.


7
James A Bristol, Walter H Moos, Bharat Trivedi: N.sup.6 -substituted adenosines for treating pain. Warner Lambert Company, Joan Thierstein, April 14, 1987: US04657897 (22 worldwide citation)

N.sup.6 -Substituted diarylalkyladenosines and pharmaceutically acceptable acid addition salts having highly desirable central nervous system and cardiovascular properties, processes for their manufacture and pharmaceutical compositions and methods for using said compounds and compositions are descr ...


8
Stephen J Johnson, Walter H Moos: Method of treating the symptoms of cognitive decline in an elderly patient employing (S)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)-methyl]-2-oxazolidinone. Warner Lambert Company, Francis J Tinney, December 11, 1990: US04977172 (19 worldwide citation)

(S)-3-Ethyl-4-[(1-methyl-1H-imidazol-5-yl)-methyl]-2-oxazolidinone or a pharmaceutically acceptable salt thereof is useful in the treatment of the symptoms of cognitive decline in an elderly patient suffering therefrom including the treatment of Alzheimer's disease.


9
Ronald N Zuckerman, Janice M Kerr, Stephen B H Kent, Walter H Moos, Reyna J Simon, Dane A Goff: Synthesis of N-substituted oligomers. Chiron Corporation, Bret Field, Kenneth M Goldman, Robert P Blackburn, November 3, 1998: US05831005 (16 worldwide citation)

A solid-phase method for the synthesis of N-substituted oligomers, such as poly (N-substituted glycines) (referred to herein as poly NSGs) is used to obtain oligomers, such as poly NSGs of potential therapeutic interest which poly NSGs can have a wide variety of side-chain substituents. Each N-subst ...


10
David J Lauffer, Walter H Moos, Hasile Tecle: Azabicycloalkane oxime & azabicycloalkene oxime muscarinic agents. Warner Lambert Company, Ruth N Newtson, June 26, 1990: US04937239 (14 worldwide citation)

Novel 1-azabicycloalkane- and alkene-oximes (Ia) and 8-azabicyclo[3.2.1]octane- and octene-oximes (Ib) are provided, these compounds being useful as agents for treating pain or for treating the symptoms of senile cognitive decline. Also provided are pharmaceutical compositions containing the compoun ...