1
Xia Mingde, Wachter Michael P, Pan Meng, Demong Duane E, Pollack Scott R: Substituted dipiperdine ccr2 antagonists. Janssen Pharmaceutica, Xia Mingde, Wachter Michael P, Pan Meng, Demong Duane E, Pollack Scott R, April 6, 2006: WO/2006/036527 (48 worldwide citation)

Substituted dipiperidine compounds of Formula (I) or a salt, isomer, prodrug, metabolite or polymorph thereof, which are CCR2 antagonists and are useful in preventing, treating or ameliorating CCR2 mediated inflammatory syndromes, disorders or diseases in a subject in need thereof.


2
Murray William V, Wachter Michael P: Pharmacologically active 2-and 3-substituted (1, 5-diaryl-3-pyrazolyl)-n-hydroxypropanamides and method for synthesizing.. Ortho Pharma, November 30, 1988: EP0293220-A2 (19 worldwide citation)

2- and 3-substituted (1 min ,5 min -diaryl-3 min -pyrazolyl)-N-hydroxypropanamides, a method for their preparation, compositions containing the same and methods of their use are disclosed. The N-hydroxypropanamides are useful in alleviating inflammatory and cardiovascular disorders in mammals.


3
Lagu Bharat, Liotta Fina, Pan Meng, Wachter Michael P, Xia Mingde: Tetrahydro-indazole cannabinoid modulators. Janssen Pharmaceutica, Lagu Bharat, Liotta Fina, Pan Meng, Wachter Michael P, Xia Mingde, sJOHNSON Philip S, October 13, 2005: WO/2005/095353 (12 worldwide citation)

This invention is direction to a tetrahydro-indazole cannabinoid modulator compound of formula I: and a method for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disorder or disease.


4
Demong Duane E, Xia Mingde, Pollack Scott R, Zheng Xiaoping, Brackley Iii James A, Wachter Michael P, Cavender Druie E, Demarest Keith T: Substituted dipiperidine as ccr2 antagonists for the treatment of inflammatory diseases. Janssen Pharmaceutica, Demong Duane E, Xia Mingde, Pollack Scott R, Zheng Xiaoping, Brackley Iii James A, Wachter Michael P, Cavender Druie E, Demarest Keith T, JOHNSON Philip S, November 15, 2007: WO/2007/130712 (9 worldwide citation)

Substituted dipiperidine compounds of Formula (I) or a form thereof, which are CCR2 antagonists and are useful in preventing, treating or ameliorating CCR2 mediated inflammatory syndromes, disorders or diseases in a subject in need thereof.


5
Wust Hans Heiner Dr, Janssen Bernd Dr, Murray William V, Wachter Michael P, Bell Stanley: Diaryl-substituted heterocyclic compound, its preparation and medicaments and cosmetics made thereof.. BASF, August 16, 1990: EP0382077-A2 (7 worldwide citation)

Verbindungen der allgemeinen Formel I worin: R und R Wasserstoff oder Methyl darstellen, A einen gegebenenfalls mit einer Methyl, Hydroxyl- oder Oxogruppe substituierten Ethylen- oder Methylenrest darstellt, L einen unsubstituierten oder durch eine Hydroxyl-, Mercapto-, C1-6-Alkyl- oder C1-4-Alkanoy ...


6
Xia Mingde, Pan Meng, Wachter Michael P, Liotta Fina: Tetrahydro pyridinyl pyrazole cannabinoid modulators. Janssen Pharmaceutica, Xia Mingde, Pan Meng, Wachter Michael P, Liotta Fina, JOHNSON Philip S, May 11, 2006: WO/2006/049880 (6 worldwide citation)

This invention is directed to a tetrahydro-pyridinyl pyrazole cannabinoid modulator compound of formula (I): and a method for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disorder or disease.


7
Beers Scott A, Malloy Elizabeth, Wachter Michael P, Wu Wei: Substituted imidazoles useful in the treatment of inflammatory diseases. Ortho Mcneil Corporation, CIAMPORCERO Audley A Jr, October 29, 1998: WO/1998/047892 (4 worldwide citation)

This invention relates to a series of substituted imidazoles of Formula (I), pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention inhibit the production of a number of inflammatory cytokines, and are useful in the treatment of diseas ...


8
Xia Mingde, Pan Meng, Wachter Michael P: Substituted 5-vinylphenyl-1-phenyl-pyrazole cannabinoid modulators. Janssen Pharmaceutica, Xia Mingde, Pan Meng, Wachter Michael P, JOHNSON Philip S, February 19, 2009: WO/2009/023653 (4 worldwide citation)

This invention is directed to a cannabinoid modulator compound of formula (I) or a form thereof, and methods for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disorder or disease.


9
Xia Mingde, Lu Huajun, Liotta Fina, Pan Meng, Wachter Michael P, Macielag Mark J: Hexahydro-cycloheptapyrazole cannabinoid modulators. Janssen Pharmaceutica, Xia Mingde, Lu Huajun, Liotta Fina, Pan Meng, Wachter Michael P, Macielag Mark J, JOHNSON Philip S, September 25, 2008: WO/2008/115705 (4 worldwide citation)

This invention is directed to a hexahydro-cycloheptapyrazole cannabinoid modulator compound of formula (I) and a method for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disorder or disease.


10
Janssen Bernd Dr, Wuest Hans Heiner Dr, Murray William V, Wachter Michael P, Bell Stanley: Phenylhydrazones, their preparation and medicaments and cosmetics manufactured therefrom.. BASF, August 16, 1990: EP0382076-A1 (3 worldwide citation)

Es werden Phenylhydrazone der Formel I worin R-R sowie m und n die in der Beschreibung angegebene Bedeutung haben, und deren Herstellung beschrieben. Die Substanzen eignen sich zur Bekämpfung von Krankheiten und als kosmetische Mittel.