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Lomonossoff George, Liu Li, Canizares Carmen, D Aoust Marc Andre, Vezina Louis Philippe: Bipartite system, method and composition for the constitutive and inducible expression of high levels of foreign proteins in plants. Plant Bioscience, Medicago, Lomonossoff George, Liu Li, Canizares Carmen, D Aoust Marc Andre, Vezina Louis Philippe, KREMER Simon, November 29, 2007: WO/2007/135480 (12 worldwide citation)

This invention comprises a combined transgene/virus vector system for the expression of heterologous proteins in plants. While exemplified with respect to the bipartite RNA plant virus, Cowpect mosaic virus (CPMV), other bipartite viral systems may be used to advantage according to the method, syste ...


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D Aoust Marc André, Couture Manon, Ors Frédéric, Trepanier Sonia, Lavoie Pierre Olivier, Dargis Michèle, Vezina Louis Philippe, Landry Nathalie: (vlps) Comprising hemagglutinin produced within a plant. Medicago, D Aoust Marc André, Couture Manon, Ors Frédéric, Trepanier Sonia, Lavoie Pierre Olivier, Dargis Michèle, Vezina Louis Philippe, Landry Nathalie, SECHLEY Konrad A, January 22, 2009: WO/2009/009876 (11 worldwide citation)

A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA pro ...


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D Aoust Marc Andre, Couture Manon, Ors Frédéric, Trepanier Sonia, Lavoie Pierre Olivier, Dargis Michèle, Vezina Louis Philippe, Landry Nathalie: Influenza virus-like particles (vlps) comprising hemagglutinin. Medicago, D Aoust Marc Andre, Couture Manon, Ors Frédéric, Trepanier Sonia, Lavoie Pierre Olivier, Dargis Michèle, Vezina Louis Philippe, Landry Nathalie, Sechley Konrad A, January 14, 2010: WO/2010/003225 (7 worldwide citation)

A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA of type A/California/04/09 in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP ...


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VEZINA LOUIS PHILIPPE: Method of preparing plant-derived vlps. MEDICAGO, Sechley Konrad A, March 31, 2011: WO/2011/035422 (5 worldwide citation)

Methods of preparing plant-derived virus like particles (VLPs) are provided. The method may comprise obtaining a plant, or plant matter comprising apoplast-localized VLPs, producing a protoplast/spheroplast fraction and apoplast fraction from the plant or plant matter, and recovering the apoplast fr ...


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D AOUST MARC ANDRE, COUTURE MANON, ORS FREDERIC, TREPANIER SONIA, LAVOIE PIERRE OLIVIER, DARGIS MICHELE, VEZINA LOUIS PHILIPPE, LANDRY NATHALIE: PSEUDO-PARTICULES DU VIRUS DE LA GRIPPE (VLP) COMPRENANT DE LHEMAGGLUTININE (HA) PRODUIT DANS UNE PLANTE, INFLUENZA VIRUS-LIKE PARTICLES (VLPS) COMPRISING HEMAGGLUTININ PRODUCED WITHIN A PLANT. MEDICAGO, MEDICAGO, GOWLING LAFLEUR HENDERSON, September 24, 2013: CA2693956 (4 worldwide citation)

A method for synthesizing influenza virus--like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA pr ...


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D AOUST MARC ANDRE, COUTURE MANON, ORS FREDERIC, TREPANIER SONIA, DARGIS MICHELE, VEZINA LOUIS PHILIPPE, LANDRY NATHALIE, LAVOIE PIERRE OLIVIER: PARTICULES PSEUDOVIRALES (VLP) DE LA GRIPPE RECOMBINEES PRODUITES DANS DES PLANTES TRANSGENIQUES EXPRIMANT LHEMAGGLUTININE, RECOMBINANT INFLUENZA VIRUS-LIKE PARTICLES (VLPS) PRODUCED IN TRANSGENIC PLANTS EXPRESSING HEMAGGLUTININ. MEDICAGO, MEDICAGO, GOWLING LAFLEUR HENDERSON, November 19, 2013: CA2707235 (4 worldwide citation)

A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA pro ...


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D AOUST Marc Andre, COUTURE Manon, LAVOIE Pierre Olivier, VEZINA Louis Philippe: PRODUCTION DE PARTICULES DE TYPE VIRAL CHEZ DES VÉGÉTAUX, VIRUS LIKE PARTICLE PRODUCTION IN PLANTS. MEDICAGO, D AOUST Marc Andre, COUTURE Manon, LAVOIE Pierre Olivier, VEZINA Louis Philippe, SECHLEY Konrad A, June 28, 2012: WO/2012/083445 (3 worldwide citation)

A method of producing a virus like particle (VLP) in a plant, and compositions comprising VLPs, are provided. The method involves introducing a nucleic acid comprising a regulatory region active in the plant and operatively linked to a chimeric nucleotide sequence encoding, in series, an ectodomain ...


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VEZINA LOUIS PHILIPPE: Method of preparing plant-derived proteins. MEDICAGO, Sechley Konrad A, March 31, 2011: WO/2011/035423 (3 worldwide citation)

Methods of preparing plant-derived proteins or suprastructure proteins, are provided. The method may comprise obtaining a plant, or plant matter comprising apoplast-localized proteins, or suprastructure proteins, producing a protoplast/spheroplast fraction and apoplast fraction from the plant or pla ...


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Couture Manon, Landry Nathalie, Vezina Louis Philippe, Dargis Michèle: Soluble recombinant influenza antigens. Medicago, Couture Manon, Landry Nathalie, Vezina Louis Philippe, Dargis Michèle, Sechley Konrad A, January 14, 2010: WO/2010/003235 (3 worldwide citation)

The present invention provides a recombinant soluble trimeric hemagglutinin (rHA) protein comprising a hemagglutinin ectodomain and an oligomerization domain. The rHA is produced as a soluble homotrimer, and may further comprises a signal peptide and/or an endoplasmic reticulum (ER) retention signal ...