1
Sehgal Surendra N, Blazekovic Teodora M, Vezina Claude: Rapamycin and process of preparation. Ayerst McKenna and Harrison, December 30, 1975: US3929992 (345 worldwide citation)

Antibiotic rapamycin is producible by culturing Streptomyces hygroscopicus NRRL 5491 in an aqueous nutrient medium. Rapamycin has antifungal properties. Methods for its preparation and use are disclosed.


2
Sehgal Surendra Nath, Baker Harold Arthur, Sidorowicz Anne Marie, Vezina Claude: Injectable composition of rapamycin.. Ayerst Mckenna & Harrison, December 16, 1981: EP0041795-A2 (55 worldwide citation)

Described is an injectable composition comprising rapamycin and a nonionic surfactant selected from polyoxyethylated fatty acids, polyoxyethylated fatty alcohols or polyoxyethylated glycerine hydroxy fatty acid esters and a method of preparing said compositions. The composition provides enhanced blo ...


3
Vezina Claude, Saucier Rene, Sehgal Surendra N: Process for the preparation of antimycin a. American Home Products Corporation, Routh John W, March 4, 1975: US3869346 (2 worldwide citation)

Improved process for the preparation of Antimycin A in which a suitable source of assimilable carbon is added during fermentation together with continuous control of pH at about pH 6.0, and an improved method of extraction is being used.


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Sehgal Surendra Nath, Vezina Claude: Ravidomycin, process of preparation and pharmaceutical compositions containing same.. Ayerst Mckenna & Harrison, May 14, 1980: EP0010964-A1

A novel antibacterial and antitumor agent, ravidomycin is described, together with pharmaceutical compositions containing it and a process for its preparation. Ravidomycin is prepared by culturing a novel microorganism Streptomyces ravidus in an aqueous nutrient medium.


5
Sehgal Surendra N, Singh Kartar, Vezina Claude: Antibiotic substances and preparation. Ayers McKenna and Harrison, October 7, 1975: US3911112

A new antibiotic complex, complex 484, components 484-A and 484-B thereof and a process for their preparation are disclosed. These antibiotic substances are producible by culturing a microorganism of the species Streptomyces in an aqueous nutrient medium under submerged aerobic fermentation conditio ...


6
Sehgal Surendra N, Vezina Claude: Ravidomycine et procede de preparation, Ravidomycin and process of preparation. Ayerst Mckenna &Amp Harrison, GOWLING LAFLEUR HENDERSON, October 26, 1982: CA1134299

ABSTRACT OF THE DISCLOSURE Ravidomycin is produced by culturing Streptomyces ravidusNRRL ?,?00 in an aqueous nutrient medium. Ravidomycin is useful asan antibacterial and antitumor agent. Methods for its preparation anduse are disclosed.


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Vezina Claude, Bolduc Cecile, Kudelski Alicia: (leucomycine) Par des souches de streptomyces kitasatoensis, (leucomycin) Complex from streptomyces kitasatoensis. Ayerst Mckenna And Harrison, January 16, 1979: CA1046438

PRODUCTION OF KITASAMYCIN(LEUCOMYCIN) COMPLEX FROM SEREPTOMYCES KITASATOENSIS Abstract of the Disclosure Herein is disclosed a high potency antibiotic complex of kitasa-mycin. The new complex is distinguished from previous preparationsof kitasamycin by containing from at least 80-90% by weight of a ...


9
Kluepfel Dieter, Sehgal Surendra N, Vezina Claude: Naphthyridinomycines produite par un streptomyces, Naphthyridinomycin antibiotics from streptomyces. Ayerst Mckenna And Harrison, January 23, 1979: CA1046965

Abstract of the Disclosure Naphthyridinomycin complex, a major component thereofcalled naphthyridinomycin A and a minor component thereof callednaphthyridinomycin B are disclosed. These antibiotic substancesexhibit antibacterial activity. The substances are producibleby culturing a microorganism of ...


10
Sehgal Surendra N, Singh Kartar, Vezina Claude: Antibiotiques et mode de preparation, Antibiotic substances and preparation thereof. Ayerst Mckenna And Harrison, January 23, 1979: CA1046966

Abstract of the Disclosure A new antibiotic complex, complex 484, components 484-Aand 484-B thereof and a process for their preparation aredisclosed. These antibiotic substances are producible byculturing a microorganism of the species Streptomyces in anaqueous nutrient medium under submerged aerobi ...