1
Valentino Stella, Roger Rajewski: Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof. University of Kansas, Birch Stewart Kolasch & Birch, July 28, 1992: US05134127 (261 worldwide citation)

Sulfoalkyl ether cyclodextrin derivatives and their use as solubilizing agents for water insoluble drugs for oral, intranasal, or parenteral administration are disclosed.


2
Bala Subramaniam, Said Saim, Roger A Rajewski, Valentino Stella: Methods for a particle precipitation and coating using near-critical and supercritical antisolvents. The University of Kansas, Hovey Williams Timmons & Collins, November 10, 1998: US05833891 (109 worldwide citation)

Improved methods and apparatus for particle precipitation and coating using near- or supercritical fluid conditions are described. A fluid dispersion having a continuous phase dispersant and at least one precipitatable substance therein is contacted with a supercritical fluid (SCF) antisolvent so as ...


3
Valentino Stella, Roger A Rajewski, James W McGinity: Sulfoalkyl ether cyclodextrin based solid pharmaceutical formulations and their use. Cydex, Rick Akin Gump Strauss Hauer & Feld L Matos, February 23, 1999: US05874418 (96 worldwide citation)

Sulfoalkyl ether-cyclodextrin (SAE-CD) based pharmaceutical formulations are provided by the present invention. These formulations comprise SAE-CD derivatives and a therapeutic agent, a major portion of which is not complexed to the SAE-CD. The present formulations are advantageously easier to prepa ...


4
Valentino Stella, Jeffrey P Krise, Jan J Zygmunt, Ingrid Gunda Georg: Water soluble prodrugs of secondary and tertiary amine containing drugs and methods of making thereof. University of Kansas, Birch Stewart Kolasch & Birch, November 16, 1999: US05985856 (89 worldwide citation)

The present invention is drawn to water soluble derivatives aliphatic acid aromatic secondary and tertiary amine containing drugs. The present invention is further drawn to methods of making water soluble derivatives of aliphatic and aromatic secondary and tertiary amine containing drugs.


5
Bala Subramaniam, Said Saim, Roger A Rajewski, Valentino Stella: Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent. The University of Kansas, Hovey Williams Timmons & Collins, February 23, 1999: US05874029 (64 worldwide citation)

A method and an apparatus useful for the production of microparticles and nanoparticles are disclosed in which a compressed fluid and a solution including a solvent and a solute are introduced into a nozzle to produce a mixture. The mixture is then passed out of the nozzle to produce a spray of atom ...


6
Valentino Stella, Laman A Al Razzak, Hans Joachim Kabbe: Aminooxodihydroisoindoloquinazoline carcinostatic agents. Bayer Aktiengesellschaft, Sprung Horn Kramer & Woods, December 25, 1990: US04980343 (2 worldwide citation)

Therapeutic compositions comprising the new derivatives of aminooxodihydroisoindolo-quinazoline of the formula ##STR1## are useful in inhibiting the growth of colon and rectal tumors.


7
Valentino Stella J: Polar drug or prodrug compositions with extended shelf-life storage and a method of making thereof. The University Of Kansas, BAILEY John W, December 17, 1998: WO/1998/056422

The present invention is drawn to pharmaceutical composition comprising cyclodextrin and a pharmaceutically active agent or prodrug, wherein the cyclodextrin is present at less than 75 % equimolar amounts of the above agent or prodrug. The present invention is further drawn to a method of extending ...


8
Valentino Stella J University: Polar drug or prodrug compositions with extended shelf-life storage and a method of making thereof. Cydex, March 22, 2000: EP0986403-A1

The present invention is drawn to pharmaceutical composition comprising cyclodextrin and a pharmaceutically active agent or prodrug, wherein the cyclodextrin is present at less than 75 % equimolar amounts of the above agent or prodrug. The present invention is further drawn to a method of extending ...



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