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Vaccaro Wayne, Chen Zhong, Dodd Dharmpal S, Huynh Tram N, Lin James, Liu Chunjian, Mussari Christopher P, Tokarski John S, Tortolani David R, Wrobleski Stephen T: Fused heterocyclic compounds useful as kinase modulators. Bristol Myers Squibb Company, Vaccaro Wayne, Chen Zhong, Dodd Dharmpal S, Huynh Tram N, Lin James, Liu Chunjian, Mussari Christopher P, Tokarski John S, Tortolani David R, Wrobleski Stephen T, DUNCAN Laurelee A, April 5, 2007: WO/2007/038314 (48 worldwide citation)

Compounds having the formula (I), and enantiomers, and diastereomers, pharmaceutically-acceptable salts, and hydrates, thereof, (I) are useful as kinase modulators, including MK2 modulation, wherein one of E and F is a nitrogen atom and the other of E and F is a carbon atom, and Z is N or CR3, and R ...


2
Burnett Duane A, Clader John W, Thiruvengadam Tiruvettipuram K, Tann Chou Hong, Lee Junning, Mcallister Timothy, Colon Cesar, Barton Derek H R, Breslow Ronald, Dugar Sundeep, Vaccaro Wayne: Substituted beta-lactam compounds useful as hypocholesterolemic agents and processes for the preparation thereof.. Schering, January 27, 1993: EP0524595-A1 (40 worldwide citation)

Novel compounds of the formula wherein A is -CH=CH-B; -C IDENTICAL C-B; -(CH2)p-X-B, wherein p is 0-2 and X is a bond, -NH- or-S(O)0-2; optionally substituted heteroaryl or benzofused heteroaryl; -C(O)-B; or wherein k is 1-2; D is B'-(CH2)mC(O)-, wherein m is 1-5; B'-(CH2)q-, wherein q is 2-6; B'-(C ...


3
Clader John W, Fevig Thomas, Vaccaro Wayne, Berger Joel G: Bicyclic amides as inhibitors of acyl-coenzyme a: cholesterol acyl transferase.. Schering, October 14, 1992: EP0508425-A1 (30 worldwide citation)

Novel bicyclic amides of the formula wherein Ar and Ar are phenyl, R-substituted phenyl, heteroaryl or R-substituted heteroaryl, wherein R is 1 to 3 substituents independently selected from the group consisting of halogeno, hydroxy, lower alkyl, lower alkoxy, nitro, amino, lower alkylamino and lower ...


4
Borzilleri Robert M, Chen Zhong, Huynh Tram N, Vaccaro Wayne, Chen Xiao Tao, Kim Kyoung S, Cai Zhen Wei: Fused heterocyclic kinase inhibitors. Bristol Myers Squibb Company, Borzilleri Robert M, Chen Zhong, Huynh Tram N, Vaccaro Wayne, Chen Xiao Tao, Kim Kyoung S, Cai Zhen Wei, GIBBONS Maureen, January 12, 2006: WO/2006/004636 (26 worldwide citation)

In general, the instant invention comprises compounds of Formulas (I) and (II) including pharmaceutically acceptable salts thereof. The compounds of the invention are useful as protein kinase inhibitors and therefore are useful for treating cancer and other protein kinase mediated diseases.


5
Vaccaro Wayne, Yang Bingwei Vera, Kim Soong Hoon, Huynh Tram, Tortolani David R, Leavitt Kenneth J, Li Wenying, Doweyko Arthur M, Chen Xiao Tao, Doweyko Lidia: Modulators of the glucocorticoid receptor and method. Bristol Myers Squibb Company, Vaccaro Wayne, Yang Bingwei Vera, Kim Soong Hoon, Huynh Tram, Tortolani David R, Leavitt Kenneth J, Li Wenying, Doweyko Arthur M, Chen Xiao Tao, Doweyko Lidia, sDAVIS Stephen, January 29, 2004: WO/2004/009017 (24 worldwide citation)

Novel non-steroidal compounds are provided which are glucocorticoid receptor modulators which are useful in treating diseases requiring glucocorticoid receptor agonist or antagonist therapy such as obesity, diabetes, inflammatory and immune disorders, and have the structure formula (I), where Z is C ...


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Yang Bingwei Vera, Doweyko Lidia M, Vaccaro Wayne, Huynh Tram N, Tortolani David R, Dhar Tg Murali: Modulators of glucocorticoid receptor, ap-1, and/or nf-ϰb activity and use thereof. Bristol Myers Squibb Company, Yang Bingwei Vera, Doweyko Lidia M, Vaccaro Wayne, Huynh Tram N, Tortolani David R, Dhar Tg Murali, DUNCAN Laurelee A, May 15, 2008: WO/2008/057862 (8 worldwide citation)

Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-ϰB activity including inflammatory and immune diseases, obesity and diabetes having the structure of formula (I) an enantiomer, diastereo ...


8
Borzilleri Robert M, Chen Zhong, Hunt John T, Huynh Tram N, Poss Michael A, Schroeder Gretchen M, Vaccaro Wayne, Wong Tai W, Chen Xiao Tao, Kim Kyoung S: Pyrrolotriazine kinase inhibitors. Bristol Myers Squibb Company, Borzilleri Robert M, Chen Zhong, Hunt John T, Huynh Tram N, Poss Michael A, Schroeder Gretchen M, Vaccaro Wayne, Wong Tai W, Chen Xiao Tao, Kim Kyoung S, GIBBONS Maureen S, January 12, 2006: WO/2006/004833 (7 worldwide citation)

In general, the instant invention comprises compounds of Formulas I and II including pharmaceutically acceptable salts thereof. The compounds of the invention are useful as protein kinase inhibitors and therefore are useful for treating cancer and other protein kinase mediated diseases.


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Weinstein David S, Yang Bingwei Vera, Kim Soong Hoon, Vaccaro Wayne, Sheppeck James, Gilmore John: Tricyclic modulators of the glucocorticoid receptor, ap-1, and/or nf-κb activity and use thereof. Bristol Myers Squibb Company, Weinstein David S, Yang Bingwei Vera, Kim Soong Hoon, Vaccaro Wayne, Sheppeck James, Gilmore John, DUNCAN Laurelee, August 11, 2005: WO/2005/072132 (6 worldwide citation)

Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I): or stereoisomers or prodrugs o ...


10
Vaccaro Wayne, Roberge Jacques Y, Leftheris Katerina, Pitts William J, Barbosa Joseph: Purine inhibitors of phosphodiesterase (pde) 7. Bristol Myers Squibb Company, Vaccaro Wayne, Roberge Jacques Y, Leftheris Katerina, Pitts William J, Barbosa Joseph, HERMENAU Ronald, December 27, 2002: WO/2002/102314 (4 worldwide citation)

Purine phosphodiesterase 7 (PDE 7) inhibitors of the following formulas(Ia, Ib), wherein R?1¿, R?2¿, Z, Y and J are described herein, and analogs thereof are provided which are useful in treating T-cell mediated diseases.