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Pau Maria Grazia, Uytdehaag Alphonsus Gerardus C, Schouten Govert Johan: Production of vaccines. Crucell Holland, June 20, 2001: EP1108787-A2 (15 worldwide citation)

Novel means and methods are provided for the production of mammalian viruses, comprising infecting a culture of immortalized human cells with the virus, incubating the culture infected with virus to propagate the virus under conditions that permit growth of the virus, and to form a virus-containing ...


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De Vocht Marcel Leo, Backus Harold Hubertus Jacobus, Van Corven Emile Johannes Jose, Lagerwerf Fija, Heemskerk Evert, Uytdehaag Alphonsus Gerardus C: Methods for the production of a whole-inactivated west nile virus vaccine. Crucell Holland, November 22, 2006: EP1724338-A1 (6 worldwide citation)

The invention relates to methods for the purification of flaviviruses, preferably West Nile Viruses. The invention also relates to methods of inactivating West Nile Viruses as well as to formulating and adjuvating West Nile Virus vaccines, wherein said formulations are suitable for use in humans.


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Pau Maria Grazia, Uytdehaag Alphonsus Gerardus C: Production of vaccines from immortalised mammalian cell lines. Introgene, May 30, 2001: EP1103610-A1 (1 worldwide citation)

Novel means and methods are provided for the production of mammalian viruses, comprising infecting a culture of immortalized human cells with the virus, incubating the culture infected with virus to propagate the virus under conditions that permit growth of the virus, and to form a virus-containing ...


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Brus Ronald Hendrik Peter, Uytdehaag Alphonsus Gerardus C, Schouten Govert Johan: Methods for the identification of antiviral compounds. Crucell Holland, November 13, 2002: EP1256803-A1

The invention is concerned among other with means and method for determining whether a compound influences a phase in the life cycle of a virus. The invention utilizes the striking observation that cells comprising a nucleic acid encoding an adenovirus early protein or a functional part, derivative ...


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Hateboer Guus, Verhulst Karina Cornelia, Schouten Govert Johan, Uytdehaag Alphonsus Gerardus C, Bout Abraham: Recombinant protein production in a human cell using sequences encoding adenovirus e1 protein. Introgene, December 12, 2001: EP1161548-A2

The present invention provides methods and compositions for the production of recombinant proteins in a human cell line. The methods and compositions are particularly useful for generating stable expression of human recombinant proteins of interest that are modified post-translationally, e.g. by gly ...


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Marzio Giuseppe, Pau Maria Grazia, Opstelten Dirk Jan Elbertus, Uytdehaag Alphonsus Gerardus C: Production of viruses, viral isolates and vaccines. Crucell Holland Bv), lin xiaogong, March 23, 2005: CN02824363

The invention provides means, methods and use for producing a virus particle, including cells therefore and virus particles thus produced. One aspect of the invention utilizes cells provided with nucleic acid encoding post-translational modification protein, thereby altering at least one property of ...



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