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Tsunoda Hidetoshi, Fukazawa Nobuyuki, Maruyama Kyoko, Nakao Toshifumi, Asada Noriaki, Takebayashi Nozomi, Kobayashi Kenji, Uda Hideyuki, Morikawa Maki: Catecholpropionic acid derivative and nuclear receptor agonist containing the same as active ingredient. Mitsui Chemicals, September 26, 2001: JP2001-261612 (11 worldwide citation)

PROBLEM TO BE SOLVED: To obtain a prophylactic or therapeutic agent for various kinds of diseases, e.g. diabetes mellitus, hyperlipidemia, arteriosclerosis, etc., by activating peroxisome proliferator-activated receptor(PPAR)-α or -γ which is a nuclear transcription factor and relates to the disease ...


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Tsunoda Hidetoshi, Fukazawa Nobuyuki, Nagase Hiroshi, Chiba Kyoko, Nakao Toshifumi, Asada Noriaki, Yamaki Toshifumi, Kibayashi Kenji, Migita Hideyuki, Morikawa Maki: Quinoline derivatives and medicinal use thereof. Mitsui Chemicals, December 18, 2002: EP1266888-A1 (6 worldwide citation)

A quinoline derivative represented by the following formula (1): allows PPAR alpha or gamma which is an intranuclear transcription factor, to function strongly and is low in toxicity. By using this compound as an active ingredient, there can be provided a preventive or therapeutic agent for various ...


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Tsunoda Hidetoshi, Chiba Kyoko: Method for producing optically active 2-phenyl-2,3- dihydroxypropylazole derivative. Mitsui Chemicals, November 19, 2003: JP2003-327578 (1 worldwide citation)

PROBLEM TO BE SOLVED: To provide a method for producing an optically active 2-phenyl-2,3- dihydroxypropylazole derivative, which is useful in the field of medicine and agrochemicals and is especially an intermediate for producing an optically active azole-based antifungal agent, by a short process i ...


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Fukazawa Nobuyuki, Kono Hiroshi, Tsunoda Hidetoshi, Nakao Toshio, Yamaki Toshibumi, Higashimura Kiichi, Ooka Hisayoshi, Watanabe Ayako: Dihydropyridazinone derivative and tumor necrosis factor production inhibitor comprising the same as active ingredient. Mitsui Chemicals, October 17, 2000: JP2000-290261 (1 worldwide citation)

PROBLEM TO BE SOLVED: To obtain a new dihydropyridazinone derivative having a strong inhibitory action on TNF-α production, hypoglycaemic action and low toxicity, capable of exhibiting excellent oral absorption, useful as a tumor necrosis factor production inhibitor and an antidiabetic medicine. SOL ...


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MIO Shigeru, NAKAMURA Mitsuo, NOGI Hidenobu, FUJIYAMA Satoko, TSUNODA Hidetoshi: [ja] ホスホノスルホン酸化合物を含有する非水電解液、及びリチウム二次電池, [fr] SOLUTION ÉLECTROLYTIQUE NON AQUEUSE CONTENANT UN COMPOSÉ DACIDE PHOSPHONOSULFONIQUE ET BATTERIE SECONDAIRE AU LITHIUM, [en] NONAQUEOUS ELECTROLYTE SOLUTION CONTAINING PHOSPHONOSULFONIC ACID COMPOUND, AND LITHIUM SECONDARY BATTERY. Mitsui Chemicals, NAKAJIMA Jun, April 25, 2013: WO/2013/058387 (1 worldwide citation)

[en] The present invention provides a nonaqueous electrolyte solution which contains a phosphonosulfonic acid compound represented by general formula (I). (In general formula (I), each of R1, R2 and R3 independently represents a hydrogen atom, an alkyl group having 1-6 carbon atoms, a haloalkyl grou ...


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Tsunoda Hidetoshi, Sekiguchi Michiru, Iizuka Hajime, Sakai Kazuya: Amino acid-n-carboxy anhydrides hvaing substituent at nitrogen. Mitsui Chemicals, April 2, 2003: EP1298127-A1

This invention provides amino acid N-carboxyanhydrides, each of which has an N-acyl substituent on its nitrogen atom, is represented by the following formula (1): readily reacts with nucleophilic reagents such as free amino acids, alcohols, anions or the like, and are intermediates useful for the hi ...


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Tsunoda Hidetoshi, Okumura Kunio, Otsuka Kengo: Optically active amine derivative and method of synthesis. Mitsui Chemicals, September 3, 2003: EP1340743-A1

A readily available and inexpensive natural alpha -amino acid is converted into a compound represented by formula (1), which is then reacted with an organometallic reagent represented by formula (2) to give an optically active 5-hydroxyoxazolidine represented by formula (3), which is then treated wi ...


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Suzuki Tsuneji, Tsunoda Hidetoshi: Optically active azole derivative and process for producing the same. Mitsui Chemicals, November 10, 2004: EP1475370-A1

The present invention provides a method for producing an optically active 2-phenyl-2,3,-dihydroxypropyl azole derivative, which is a useful compound in the field of medicines and agricultural chemicals, and is, in particular, a significantly important intermediate in the step of producing an optical ...


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Furuya Masayuki, Tsunoda Hidetoshi, Suzuki Tsuneji, Nagatomo Akinori, Wada Masaru: Process for producing glycoside. Mitsui Chemicals, June 22, 2005: EP1544207-A1

A glycoside in which at least two phenolic hydroxyl groups of a compound having at least two phenolic hydroxyl groups in its molecule are glycosidically linked to anomeric carbon atoms of at least two sugar molecules can be prepared with high yield by a method including the step of allowing phenolic ...