1
Kimihiro Shimizu, Tsuguji Nakahara, Taketoshi Kinoshita, Jun Takatsuka, Michiko Igarashi: Plasminogen activator derivatives. Nippon Chemiphar Company, Oblon Fisher Spivak McClelland & Maier, February 3, 1987: US04640835 (346 worldwide citation)

Derivatives of a nonimmunogenic plasminogen activator which comprises at least one polyalkylene glycol group chemically bonded with at least one coupling agent to amino acid side chains of said plasminogen activator, wherein said polyalkylene glycol has a molecular weight of about 200-20,000 and is ...


2
Kimihiro Shimizu, Tsuguji Nakahara, Taketoshi Kinoshita: Plasminogen activator derivatives. January 22, 1985: US04495285 (91 worldwide citation)

A derivative of a human-originated non-immunogenic plasminogen activator is disclosed which comprises at least one polyalkylene glycol attached with at least one coupling agent to amino acid side chains of said plasminogen activator, said polyalkylene glycol having a molecular weight of 200-20,000 a ...