1
Hiroshi Yoshino, Norihiro Ueda, Hiroyuki Sugumi, Jun Niijima, Yoshihiko Kotake, Toshimi Okada, Nozomu Koyanagi, Tatsuo Watanabe, Makoto Asada, Kentaro Yoshimatsu, Atsumi Iijima, Takeshi Nagasu, Kappei Tsukahara, Kyosuke Kitoh: Sulfonamide derivatives. Eisai, Flynn Thiel Boutell & Tanis, October 5, 1993: US05250549 (28 worldwide citation)

Sulfonamide derivatives of the general formula (I): ##STR1## wherein preferably R.sup.1 represents a lower alkoxy group, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are as defined in the specification, A and B may be the same or different from each other and each represents .dbd.N-- or . ...


2
Hiroshi Yoshino, Norihiro Ueda, Hirovuki Sugumi, Jun Niijima, Yoshihiko Kotake, Toshimi Okada, Nozomu Koyanagi, Tatsuo Watanabe, Makoto Asada, Kentaro Yoshimatsu, Atsumi Iijima, Takeshi Nagasu, Kappei Tsukahara, Kyosuke Kitoh: Sulfonamide phenyl substituted compounds. Eisai, Flynn Thiel Boutell & Tanis P C, March 11, 1997: US05610320 (18 worldwide citation)

Sulfonamide compounds of the formula or pharmacologically acceptable salts thereof: ##STR1## wherein: R.sup.1 is a hydrogen atom, halogen atom, lower alkyl group, lower alkoxy group, hydroxyl group, nitro group, phenoxy group, cyano group, acetyl group, amino group or a protected amino group; R.sup. ...


3
Hiroshi Yoshino, Norihiro Ueda, Hiroyuki Sugumi, Jun Niijima, Yoshihiko Kotake, Toshimi Okada, Nozomu Koyanagi, Tatsuo Watanabe, Makoto Asada, Kentaro Yoshimatsu, Atsumi Iijima, Takeshi Nagasu, Kappei Tsukahara, Kyosuke Kitoh: Sulfonamide derivatives. Eisai, Flynn Thiel Boutell & Tanis, March 8, 1994: US05292758 (8 worldwide citation)

Sulfonamide derivatives of the general formula (I): ##STR1## wherein preferably R.sup.1 represents a lower alkoxy group, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 may be the same or different from one another and each represent a hydrogen atom, halogen atom or lower alkyl group, A and ...


4

5
Toshimi Okada, Nobuyuki Kurusu, Keigo Tanaka, Seiji Yoshikawa, Daisuke Shinmyo, Nobuhisa Watanabe, Hironori Ikuta, Hironobu Hiyoshi, Takao Saeki, Mamoru Yanagimachi, Masashi Ito: N-aryl-substituted cyclic amine derivative and medicine containing the same as active ingredient. Eisai, Birch Stewart Kolasch and Birch, September 26, 2006: US07112593 (4 worldwide citation)

An excellent squalene synthase inhibitor is provided. Specifically, what is provided is a compound (I) represented by the following formula, a salt thereof or a hydrate of them. In formula (I), R1 represents an optionally substituted vinyl group or an aromatic ring which may be substituted. Also, n ...


6
Hiroshi Yoshino, Norihiro Ueda, Hiroyuki Sugumi, Jun Niijima, Yoshihiko Kotake, Toshimi Okada, Nozomu Koyanagi, Tatsuo Watanabe, Makoto Asada, Kentaro Yoshimatsu, Atsumi Iijima, Takeshi Nagasu, Kappei Tsukahara, Kyosuke Kitoh: Pyridine carboxamide compounds which have useful as pharmaceutical utility. Eisai, Flynn Thiel Boutell & Tanis, July 26, 1994: US05332751 (4 worldwide citation)

Sulfonamide derivatives of the general formula (I): ##STR1## wherein preferably R.sup.1 represents a lower alkoxy group, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 may be the same or different from one another and each represent a hydrogen atom, halogen atom or lower alkyl group, A and ...


7
Toshimi Okada, Nobuyuki Kurusu, Keigo Tanaka, Kazuki Miyazaki, Daisuke Shinmyo, Hiroyuki Sugumi, Hironori Ikuta, Hironobu Hiyoshi, Takao Saeki, Mamoru Yanagimachi, Masashi Ito: Quinuclidine compounds and drugs containing the same as the active ingredient. Eisai, Birch Stewart Kolasch & Birch, July 29, 2003: US06599917 (2 worldwide citation)

The present invention provides an excellent squalene synthesizing enzyme inhibitor. Specifically, it provides a compound (I) represented by the following formula, a salt thereof or a hydrate of them.


8
Sueo Machi, Isao Ishigaki, Toshimi Okada, Shigeaki Washio: Radiation polymerization of cationic monomer in aqueous alcohol. Japan Atomic Energy Research Institute, Taki Chemical, Browdy and Neimark, October 19, 1982: US04354907 (2 worldwide citation)

A process for the production of water-soluble, substantially solid, cationic polymers comprises the step of irradiating an aqueous solution with ionizing radiation, the aqueous solution comprising at least 50% by weight of one, or two or more of specific type of amino ester or esters optionally bein ...


9
Hiroshi Yoshino, Norihiro Ueda, Hiroyuki Sugumi, Jun Niijima, Yoshihiko Kotake, Toshimi Okada, Nozomu Koyanagi, Tatsuo Watanabe, Makoto Asada, Kentaro Yoshimatsu, Atsumi Iijima, Takeshi Nagasu, Kappei Tsukahara, Kyosuke Kitoh: Sulfonamide derivatives. Eisai, Flynn Thiel Boutell & Tanis, July 18, 1995: US05434172 (1 worldwide citation)

Sulfonamide derivatives of the general formula (I): ##STR1## wherein preferably R.sup.1 represents a lower alkoxy group, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 may be the same or different from one another and each represent a hydrogen atom, halogen atom or lower alkyl group, A and ...


10
Nobuyuki Yasuda, Tadashi Nagakura, Kazuto Yamazaki, Seiji Yoshikawa, Toshimi Okada, Hironori Ikuta, Mika Koyanagi: Pharmaceutical use of N-carbamoylazole derivatives. Eisai R & D Management, Morgan & Finnegan, July 3, 2007: US07238720 (1 worldwide citation)

The present invention relates to use of 1-carbamoylazole derivatives as medicaments and pharmaceutical compositions containing 1-carbamoylazole derivatives as the active ingredient, based on their DPPIV inhibiting effects. The present invention provides a dipeptidyl peptidase IV inhibiting agent com ...