1
Shiro Nankai, Mariko Kawaguri, Toshihiko Yoshioka, Haruhiro Tsutsumi, Kyozo Terao, Naoki Tanimoto, Masahiro Yoshioka, Hiroshi Hyodo, Takatoshi Uchigaki: Quantitative analysis method and its system using a disposable sensor. Matsushita Electric Industrial, Kyoto Daiichi Kagaku, November 30, 1993: US05266179 (788 worldwide citation)

A sensor 13 is inserted into a connector 14. A constant voltage required to obtain a response current is applied across the connector 14 by a voltage applying source 15 at timings required. A response current of the sensor 13 inserted into the connector 14 is converted into a voltage by a current-to ...


2
Shin Ikeda, Toshihiko Yoshioka, Shiro Nankai, Haruhiro Tsutsumi, Hideyuki Baba, Yoshinobu Tokuno, Syoji Miyazaki: Biosensor, and a method and a device for quantifying a substrate in a sample liquid using the same. Matsushita Electric Industrial, Renner Otto Boisselle & Sklar, December 10, 1996: US05582697 (652 worldwide citation)

The biosensor of this invention can quantify a substrate in a sample liquid by electrochemically measuring the amount of an electron acceptor that has been reduced by electrons generated in a reaction between the substrate and an oxidoreductase. The biosensor has an electrically insulating substrate ...


3
Toshihiko Yoshioka, Shiro Nankai: Biosensor and a method for measuring a concentration of a substrate in a sample. Matsushita Electric Industrial, Renner Otto Boisselle & Sklar, November 23, 1993: US05264103 (645 worldwide citation)

The present invention provides a biosensor comprising an electrical insulating substrate, a main electrode system formed on the substrate and having a working electrode and a counter electrode, a reaction layer provided in contact with or in the vicinity of the main electrode system and containing a ...


4
Toshihiko Yoshioka, Shiro Nankai: Biosensor utilizing enzyme and a method for producing the same. Matsushita Electric Industrial, Panitch Schwarze Jacobs & Nadel, March 9, 1993: US05192415 (457 worldwide citation)

The biosensor of the present invention quantifies a substrate contained in a sample liquid by reducing electron acceptors using electron generated in a reaction of the substrate to enzyme and then by measuring the reduced amount of the electron acceptors electrochemically. The biosensor has an elect ...


5
Shin Ikeda, Toshihiko Yoshioka, Shiro Nankai, Haruhiro Tsutsumi, Hideyuki Baba, Yoshinobu Tokuno, Syoji Miyazaki: Biosensor, and a method and a device for quantifying a substrate in a sample liquid using the same. Matsushita Electric Industrial, Renner Otto Boisselle & Sklar, July 22, 1997: US05650062 (447 worldwide citation)

The biosensor of this invention can quantify a substrate in a sample liquid by electrochemically measuring the amount of an electron acceptor that has been reduced by electrons generated in a reaction between the substrate and an oxidoreductase. The biosensor has an electrically insulating substrate ...


6
Shin Ikeda, Mariko Miyahara, Toshihiko Yoshioka, Shiro Nankai: Biosensor and method for producing the same. Matsushita Electric Industrial, Panitch Schwarze Jacobs & Nadel P C, November 19, 1996: US05575895 (446 worldwide citation)

A biosensor for quantification of a specific component contained in various biological samples comprises an electrically insulating base plate, an electrode system including a working electrode and a counter electrode which are provided on the electrically insulating base plate, a reaction layer for ...


7
Toshihiko Yoshioka, Mariko Kawaguri, Shiro Nankai: Preparation of biosensor having a layer containing an enzyme, electron acceptor and hydrophilic polymer on an electrode system. Matsushita Electric Industrial, Wenderoth Lind & Ponack, July 20, 1993: US05229282 (442 worldwide citation)

The present invention relates to a process of preparation of a biosensor comprising forming an electrode system mainly containing carbon on an insulating base plate, treating the surface of electrode system with an organic solvent, and then arranging a reaction layer on the electrode system to give ...


8
Keiko Yukawa, Toshihiko Yoshioka, Shiro Nankai: Biosensor. Matsushita Electric Industrial, McDermott Will & Emery, May 9, 2000: US06059946 (360 worldwide citation)

The present invention provides a stable and cost-effective biosensor. The biosensor includes an electrically insulating base plate, an electrode system that includes at least a working electrode and counter electrode formed on the base plate, a reaction layer containing at least an enzyme, an electr ...


9
Toshihiko Yoshioka, Shin Ikeda, Shiro Nankai: Biosensor. Matsushita Electric Industrial, Renner Otto Biosselle & Sklar, July 29, 1997: US05651869 (324 worldwide citation)

The biosensor of this invention includes an electrically insulating substrate; an electrode system formed on the substrate which includes a working electrode and a counter electrode; and a reaction layer formed on the substrate or above the substrate with a space therebetween. The reaction layer inc ...


10
Shin Ikeda, Toshihiko Yoshioka, Shiro Nankai, Haruhiro Tsutsumi, Hideyuki Baba, Yoshinobu Tokuno: Method for quantifying specific compound. Matsushita Electric Industrial, McDermott Will & Emery, October 15, 1996: US05565085 (291 worldwide citation)

A biosensor for quantifying a specific compound has a reaction layer containing at least an enzyme, and an electrode system having a working electrode and a counter electrode formed on an insulating base plate; the biosensor detects the specific compound contained in a sample on the basis of an elec ...