1
Starrett Jr John E, Yu Kuo Long, Mansuri Murammil M, Tortolani David R: Substituted (5,6)-dihydronaphthalenyl compounds having retinoid-like activity.. Squibb Bristol Myers Co, July 5, 1995: EP0661259-A1 (97 worldwide citation)

The present invention relates to a compound of formula I or a nontoxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof, in which X is -O-CO-, -NH-CO-, -CS-NH-, -CO-O-, -CO-NH-, -COS-, -SCO-, -SCH2-, -CH2-CH2-, -C IDENTICAL C-, -CH2-NH-, -COCH2-, -NHCS-, -CH2S- ...


2
Starrett John Edward Jr, Mansuri Muzammil M, Martin John C, Tortolani David R, Bronson Joanne J: Prodrugs of phosphonates.. Squibb Bristol Myers Co, April 22, 1992: EP0481214-A1 (74 worldwide citation)

There are disclosed novel oral prodrugs of phosphonate nucleotide analogs which are hydrolyzable under physiological conditions to yield compounds which are useful as antiviral agents, especially as agents effective against RNA and DNA viruses. They may also find use as antitumor agents.


3
Starrett Jr John E, Mansuri Muzammil N, Tortolani David R: Phenyl or phenylalkyl substituted naphtalene derivatives having retinoid-like activity as well as anti-tumor activities.. Squibb Bristol Myers Co, July 5, 1995: EP0661261-A1 (54 worldwide citation)

This invention relates to a retinoid compound of formula I in which Y is -CO-NH-, -CR=CR-, -CO-O-, -O-CO-, -C(=S)-NH-, -C IDENTICAL C-, -O-CH2-, -CH2-O-, or -CH2-CH2-; A is -(CH2)t- or a bond; Q is phenyl optionally substituted with one to three same or different C1-6alkyl, C1-6alkoxy, halogen, or - ...


4
Vaccaro Wayne, Chen Zhong, Dodd Dharmpal S, Huynh Tram N, Lin James, Liu Chunjian, Mussari Christopher P, Tokarski John S, Tortolani David R, Wrobleski Stephen T: Fused heterocyclic compounds useful as kinase modulators. Bristol Myers Squibb Company, Vaccaro Wayne, Chen Zhong, Dodd Dharmpal S, Huynh Tram N, Lin James, Liu Chunjian, Mussari Christopher P, Tokarski John S, Tortolani David R, Wrobleski Stephen T, DUNCAN Laurelee A, April 5, 2007: WO/2007/038314 (47 worldwide citation)

Compounds having the formula (I), and enantiomers, and diastereomers, pharmaceutically-acceptable salts, and hydrates, thereof, (I) are useful as kinase modulators, including MK2 modulation, wherein one of E and F is a nitrogen atom and the other of E and F is a carbon atom, and Z is N or CR3, and R ...


5
Vaccaro Wayne, Yang Bingwei Vera, Kim Soong Hoon, Huynh Tram, Tortolani David R, Leavitt Kenneth J, Li Wenying, Doweyko Arthur M, Chen Xiao Tao, Doweyko Lidia: Modulators of the glucocorticoid receptor and method. Bristol Myers Squibb Company, Vaccaro Wayne, Yang Bingwei Vera, Kim Soong Hoon, Huynh Tram, Tortolani David R, Leavitt Kenneth J, Li Wenying, Doweyko Arthur M, Chen Xiao Tao, Doweyko Lidia, sDAVIS Stephen, January 29, 2004: WO/2004/009017 (23 worldwide citation)

Novel non-steroidal compounds are provided which are glucocorticoid receptor modulators which are useful in treating diseases requiring glucocorticoid receptor agonist or antagonist therapy such as obesity, diabetes, inflammatory and immune disorders, and have the structure formula (I), where Z is C ...


6

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Yang Bingwei Vera, Doweyko Lidia M, Vaccaro Wayne, Huynh Tram N, Tortolani David R, Dhar Tg Murali: Modulators of glucocorticoid receptor, ap-1, and/or nf-ϰb activity and use thereof. Bristol Myers Squibb Company, Yang Bingwei Vera, Doweyko Lidia M, Vaccaro Wayne, Huynh Tram N, Tortolani David R, Dhar Tg Murali, DUNCAN Laurelee A, May 15, 2008: WO/2008/057862 (8 worldwide citation)

Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-ϰB activity including inflammatory and immune diseases, obesity and diabetes having the structure of formula (I) an enantiomer, diastereo ...


8
Poss Michael A, Tortolani David R, Mattson Ronald J, Yevich Joseph P: Antidepressant heterocyclic compounds. Squibb Bristol Myers Co, October 24, 2001: EP1146871-A1

Compounds of formula (I) are useful antidepressant agents demonstrating potent inhibition of 5-HT reuptake. Z is selected from among various phenyl and hetaryl moieties while Y is benzyl or indolyl.


9
Starrett John E Jr, Tortolani David R, Mansuri Muzammil M, Meanwell Nicholas A: Retinoid-like heterocycles. Squibb Bristol Myers Co, October 9, 1996: EP0736530-A2

This invention relates to a compound of formula I in which T is -CONH- or -CH=CH-; R and R are independently C1-6 alkyl; R is C1-6 alkyl or hydrogen; and R is heteroaryl; or a non-toxic pharmaceutically-acceptable salt, physiologically-hydrolyzable ester or solvate thereof.


10
Vaccaro Wayne, Yang Bingwei Vera, Kim Soong Hoon, Huynh Tram, Tortolani David R, Leavitt Kenneth J, Li Wenying, Doweyko Arthur M, Chen Xiao Tao, Doweyko Lidia: Modulators of the glucocorticoid receptor and method. Squibb Bristol Myers Co, June 1, 2005: EP1534273-A2

Novel non-steroidal compounds are provided which are glucocorticoid receptor modulators which are useful in treating diseases requiring glucocorticoid receptor agonist or antagonist therapy such as obesity, diabetes, inflammatory and immune disorders, and have the structure formula (I), where Z is C ...