1
John E Park, Cornelia Dorner Ciossek, Stefan Hoerer, Lothar Kussmaul, Martin Lenter, Katharina Zimmermann, Gerald Beste, Toon Laeremans, Pascal Merchiers, Jo Vercammen: A-beta binding polypeptides. Boehringer Ingelheim International, Michael P Morris, David L Kershner, December 25, 2012: US08337845 (3 worldwide citation)

The invention relates to biparatopic A-beta binding polypeptides and, more specifically, to biparatopic A-beta binding polypeptides comprising at least two immunoglobulin single variable domains binding to different epitopes of A-beta. The invention also relates to specific sequences of such polypep ...


2
John E Park, Cornelia Dorner Ciossek, Stefan Hoerer, Lothar Kussmaul, Martin Lenter, Katharina Zimmermann, Gerald Beste, Toon Laeremans, Pascal Merchiers, Jo Vercammen: Nucleic acid molecules encoding A-beta binding polypeptides. Boehringer Ingelheim International, Michael P Morris, David L Kershner, December 24, 2013: US08614308 (1 worldwide citation)

The invention relates to biparatopic A-beta binding polypeptides and, more specifically, to biparatopic A-beta binding polypeptides comprising at least two immunoglobulin single variable domains binding to different epitopes of A-beta. The invention also relates to specific sequences of such polypep ...


3
Sanjaya Singh, Alisa K Waterman, Erik Depla, Toon Laeremans, Diane Van Hoorick, Cedric Jozef Néotère Ververken: CX3CR1-binding polypeptides comprising immunoglobulin single variable domains. Boehringer Ingelheim International, Michael P Morris, Edward S Lazer, May 19, 2015: US09035029 (1 worldwide citation)

The present invention relates to CX3CR1-binding polypeptides, in particular polypeptides comprising specific immunoglobulin domains. The invention also relates to nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing s ...


4
Jan Steyaert, Toon Laeremans, Els Pardon: Chimeric polypeptides comprising G protein-coupled receptors and VHH antibodies. VIB VZW, Vrije Universiteit Brussel, TraskBritt P C, March 14, 2017: US09593157

Described are polypeptides and their use for screening and drug discovery. More specifically, the disclosure provides chimeric polypeptides comprising a membrane protein, in particular a GPCR, fused to a binding domain, wherein the binding domain is directed against and/or specifically binds to the ...


5
John E Park, Cornelia Dorner Ciossek, Stefan Hoerer, Lothar Kussmaul, Martin Lenter, Katharina Zimmerman, Gerald Beste, Toon Laeremans, Pascal Gerard Merchiers, Jo Vercammen: A-beta binding polypeptides. Ablynx, Wolf Greenfield & Sacks P C, December 15, 2015: US09211330

The invention relates to biparatopic A-beta binding polypeptides and, more specifically, to biparatopic A-beta binding polypeptides comprising at least two immunoglobulin single variable domains binding to different epitopes of A-beta. The invention also relates to specific sequences of such polypep ...


6
Jan Steyaert, Els Pardon, Soren Rasmussen, Juan Fung, Brian Kobilka, Toon Laeremans: Protein binding domains stabilizing functional conformational states of GPCRs and uses thereof. VIB VZW, Vrije Universiteit Brussel, The Board of Trustees of the Leland Stanford Junior University, TraskBritt P C, September 27, 2016: US09453065

The disclosure relates to the field of GPCR structure biology and signaling. In particular, it relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifically, it provides protein bi ...


7
Jan Steyaert, Juan Jose Fung, Brian Kobilka, Toon Laeremans, Els Pardon, Soren G F Rasmussen: Protein binding domains stabilizing functional conformational states of GPCRs and uses thereof. VIB VZW, Vrije Universiteit Brussel, The Board of Trustees of the Leland Stanford Junior University, TraskBritt P C, June 27, 2017: US09689872

The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifical ...


8
Toon Laeremans, Catelijne Stortelers, Friedrich Nolte, Maria Gonzalez Pajuelo, Joana Assunção, Philippe Van Rompaey: Method for generation of immunoglobulin sequences. Ablynx, Wolf Greenfield & Sacks P C, February 16, 2016: US09260508

The present invention relates to a method for generating immunoglobulin sequences against cell-associated antigens, more particularly, antigens that are membrane-anchored. The invention also provides immunoglobulin sequences obtainable by the method of the invention. Specifically, the present invent ...


9
Sanjaya Singh, Alisa K Waterman, Erik Depla, Toon Laeremans, Diane Van Hoorick, Cedric Jozef Néotère Ververken: Method for treating a CX3CR1-associated disease with CX3CR1-binding polypeptides. Boehringer Ingelheim International, Michael P Morris, Edward S Lazer, October 4, 2016: US09458235

The present invention relates to CX3CR1-binding polypeptides, in particular polypeptides comprising specific immunoglobulin domains. The invention also relates to nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing s ...


10
Toon Laeremans, Paul PMP Van Bergen En Henegouwen: Camelidae single domain antibodies vhh directed against epidermal growth factor receptor and uses therefor. Wolf Greenfield & Sacks PC, October 12, 2006: US20060228355-A1

The present invention relates to antibodies directed to Epidermal Growth Factor Receptor that are single domain antibodies Camelidae VHHs. It further relates to methods of of use of said polypeptides.



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