1
Kevin Rodzinak
Jeannie M Arruda, Brian T Campbell, Nicholas D P Cosford, Jacob M Hoffman, Essa H Hu, Mark E Layton, Yiwei Li, Jun Liang, Kevin J Rodzinak, Tony Siu, Brian A Stearns, Lida R Tehrani, Mark T Bilodeau, Peter J Manley: Inhibitors of Akt activity. Merck Sharp & Dohme, Matthew A Leff, David A Muthard, March 22, 2011: US07910561 (1 worldwide citation)

The present invention is directed to compounds which contain substituted naphthyridines which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer ...


2
Kevin Rodzinak
Jeannie M Arruda, Brian T Campbell, Nicholas DP Cosford, Jacob M Hoffman, Essa H Hu, Mark E Layton, Yiwei Li, Jun Liang, Kevin J Rodzinak, Tony Siu, Brian A Stearns, Lida R Tehrani, Mark T Bilodeau, Peter J Manley: Inhibitors of Akt Activity. Merck And Co, November 20, 2008: US20080287457-A1

The present invention is directed to compounds which contain substituted naphthyridines which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer ...


3

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Mark T Bilodeau, Nicholas D P Cosford, John C Hartnett, Yiwei Li, Jun Liang, Peter J Manley, Lou Anne Neilson, Tony Siu, Zhicai Wu: Inhibitors of Akt activity. Merck & Co, Matthew A Leff, David A Muthard, June 9, 2009: US07544677 (5 worldwide citation)

The present invention is directed to compounds which contain substituted 5-deazapteridine moieties which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treat ...


5
Seyamak Vaziri, Bhaskar Peddinti, Jennifer Kay Walker, Daniel Eskenazi, Tony Siu Kong Leung: Connector for telecommunication devices. Cisco Technology, BainwoodHuang, March 10, 2009: US07500880 (4 worldwide citation)

A connector that mechanically connects and provides power to two or more telecommunication devices in series, for example a phone and an expansion module or accessory device, from a single or multiple power source is provided. In one embodiment, the connector includes a support body and a pair of ou ...


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Weiming Fan, Thomas F N Haxell, Matthew G Jenks, Nobuhiko Kawanishi, Shuliang Lee, Hao Liu, Michael J Malaska, Joseph A Moore III, Yoshio Ogino, Yu Onozaki, Bharathi Pandi, Michael R Peel, Toshihiro Sakamoto, Tony Siu: Inhibitors of Akt activity. Merck Sharp & Dohme, MSD, Yong Zhao, Laura M Ginkel, Matthew A Leff, December 24, 2013: US08614221 (1 worldwide citation)

The instant invention provides for substituted fused naphthyridine derivatives that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibi ...


8
Tony Siu, Jonathan Young, Michael Altman, Alan Northrup, Ekaterina Kozina, Christopher Dinsmore, David J Guerin, Kevin A Keenan, Joon O Jung, Solomon Kattar, Rachel N MacCoss: Inhibitors of janus kinases and/or 3-phosphoinositide-dependent protein kinase-1. Merck Sharp & Dohme, Laura M Ginkel, David A Muthard, December 11, 2012: US08329722

The instant invention provides for compounds that inhibit JAK2 tyrosine kinase and/or PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting JAK2 tyrosine kinase activity and/or PDK1 kinase inhibitory activity by administering the compound t ...


9
Michael Altman, Matthew Christopher, Jonathan B Grimm, Andrew Haidle, Kaleen Konrad, Jongwon Lim, Rachel N MacCoss, Michelle Machacek, Ekundayo Osimboni, Ryan D Otte, Tony Siu, Kerrie Spencer, Brandon Taoka, Paul Tempest, Kevin Wilson, Hyun Chong Woo, Jonathan Young, Anna Zabierek: Inhibitors of janus kinases. Merck Sharp & Dohme, Laura M Ginkel, David A Muthard, February 5, 2013: US08367706

The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 TYK2 and PDK1 by administe ...


10
Jason Brubaker, Joshua Close, Tony Siu, Graham Frank Smith, Luis E Torres, Hyun Chong Woo, Jonathan R Young, Zhongyong Wei, Feng Shi: Pyrazole carboxamides as Janus kinase inhibitors. Merck Sharp & Dohme, Patricia A Shatynski, Catherine D Fitch, July 19, 2016: US09394282

The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.



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