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Constantine G Boojamra, Lee S Chong, Scott J Hecker, Tomasz W Glinka, Dale E Shuster: Florfenicol-type antibiotics. Schering Plough Animal Health Corporation, May 9, 2006: US07041670 (22 worldwide citation)

The present invention relates to novel florfenicol compounds having the chemical structure: wherein the compounds are useful for the treatment and/or prevention of bacterial infections in a broad range of patients such as, without limitation, birds, fish, shellfish and mammals.


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Burton G Christensen, In Seop Cho, Tomasz W Glinka, Scott J Hecker: Substituted-pyridinyl cephalosporin antibiotics active against methicillin resistant bacteria. Microcide Pharmaceuticals, Lyon & Lyon, August 4, 1998: US05789584 (14 worldwide citation)

The present invention includes (7R)-7-(acylamino)-3-(substituted-pyridinyl)-3-cephem-4-carboxylic acids or their pharmacologically acceptable salts which exhibit antibiotic activity against methicillin-resistant bacteria and are therefore useful as antibacterial agents.


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Scott Hecker, Sunil V Pansare, Tomasz W Glinka: Florfenicol prodrug having improved water solubility. Schering Plough Animal Health Corporation, December 26, 2006: US07153842 (11 worldwide citation)

The present invention discloses phosphate esters of florfenicol (prodrugs) and florfenicol analogs having superior water solubility that are hydrolyzed to florfenicol or the respective florfenicol analog in vivo, upon administration to an animal.


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Dale E Shuster, Scott Hecker, Tomasz W Glinka, Rajeshwar Singh, Zhuoyi Su: Antibacterial 1-(4-mono- and di-halomethylsulphonylphenyl)-2-acylamino-3-fluoroproponals and preparation thereof. Schering Plough Animal Health Corporation, April 22, 2008: US07361689 (10 worldwide citation)

Novel florfenicol compounds having the chemical structure: or a pharmaceutically-acceptable salt thereof or a solvate thereof, or prodrug thereof, wherein R1 is CHCl2, CHClF, CHF2, CHBrCl, CH3, CH2N3, CH2CN, CH(R2)NH2 or CH X1X2; where R2 is H, CH3 or CH2OH, and X1 and X2 are independently selected ...


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Eric E Allen, Nancy Kevin, Tomasz W Glinka, Ralph A Rivero: Angiotensin II antagonists incorporating a substituted thiophene or furan. Merck & Co, Joseph F DiPrima, Valerie J Camara, October 12, 1993: US05252574 (7 worldwide citation)

Substituted heterocycles attached through a methylene bridge to novel substituted phenyl thiophene or phenyl furan derivative of the Formula I are useful as angiotensin II antagonists. ##STR1##


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In Seop Cho, Scott J Hecker, Tomasz W Glinka, Ving J Lee, Zhijia J Zhang: Cephalosporin antibiotics. Microcide Pharmaceuticals, Lyon & Lyon, February 15, 2000: US06025352 (5 worldwide citation)

The present invention includes novel compounds of formula ##STR1## where G, H, J, L and M are carbon or nitrogen, R.sup.99 is selected from the group consisting of sulfur, SO, SO.sub.2, NH, N-alkyl, oxygen, C.tbd.C (cis or trans), and C.tbd.C, and R.sup.12 is NR.sup.13 R.sup.14, ##STR2## The inventi ...


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Scott J Hecker, Sunil V Pansare, Tomasz W Glinka: Florfenicol prodrug having improved water solubility. Schering Plough Animal Health, David J Kerwick, August 11, 2009: US07572777 (5 worldwide citation)

The present invention discloses methods of using phosphate esters of florfenicol (prodrugs) and florfenicol analogs having superior water solubility that are hydrolyzed to florfenicol or the respective florfenicol analog in vivo, upon administration to an animal.