1
Todd E French, Douglas N Modlin, John C Owicki, James S Richey, Lev J Leytes, Enal S Razvi: Methods and apparatus for detecting nucleic acid polymorphisms. LJL BioSystems, Kolisch Hartwell Dickinson McCormack & Heuser, October 2, 2001: US06297018 (150 worldwide citation)

Methods and apparatus for detecting polynucleotide hybridization in luminescence-based assays. The methods may include (1) allele-specific hybridization, using luminescence detection, (2) allele-specific oligonucleotide ligation, using dye-labeled oligonucleotide ligation with luminescence resonance ...


2
Douglas N Modlin, John C Owicki, Jon F Petersen, Todd E French, Carl L Wright, Jeanne A Ruiz, Lorne E Bechtel: Multi-mode light detection system. Molecular Devices Corporation, Kolisch Hartwell P C, November 30, 2004: US06825921 (108 worldwide citation)

Apparatus and methods for combining multiple modes and methods of optical detection, postprocessing, and/or feedback loops in bioanalytical measurements. The methods may include (1) positioning a composition at an examination site in a multi-mode instrument; (2) detecting light transmitted form the ...


3
Douglas N Modlin, Todd E French, John C Owicki: Apparatus and methods for time-resolved spectroscopic measurements. LJL BioSystems, Kolisch Hartwell PC, November 19, 2002: US06483582 (30 worldwide citation)

Apparatus and methods for measuring light transmitted from a sample. The apparatus may include a stage, a light source, and a detector. The stage may be configured to hold a microplate having a plurality of sample wells. The apparatus may be configured to take frequency-domain time-resolved measurem ...


4
Joseph H Jackson III, Dean G Hafeman, Todd E French: Light detection device. Molecular Devices Corporation, Dorsey & Whitney, August 16, 2005: US06930314 (22 worldwide citation)

Apparatus and methods for optical illumination and/or detection with improved flexibility and/or read speed. The apparatus and methods may include mechanisms for selecting and switching between multiple excitation wavelengths and/or simultaneously reading from a plurality of sample sites. The appara ...


5
Todd E French, David P Stumbo, Douglas N Modlin: Frequency-domain light detection device. LJL Biosystems, Kolisch Hartwell Dickinson McCormack & Heuser, November 13, 2001: US06317207 (15 worldwide citation)

Apparatus and methods for determining temporal properties of photoluminescent samples using frequency-domain photoluminescence measurements, where the measurements may include photon counting and/or the separation of measured luminescence into potentially overlapping time bins.


6
Douglas N Modlin, David P Stumbo, Rick V Stellmacher, Jonathan F Petersen, Todd E French: Broad range light detection system. Molecular Devices Corporation, Kolisch Hartwell P C, January 31, 2006: US06992761 (7 worldwide citation)

Broad-range light-detection systems, including components and methods of use thereof. These systems may include apparatus and methods for detecting light with increased speed and/or detection efficiency, particularly in applications involving repeated analysis of the same sample and/or successive an ...


7
Wu Jiang, Todd E French, David P Stumbo: Reflective optic system for imaging microplate readers. Molecular Devices Corporation, Morgan Lewis & Bockius, David J Brezner, Victor E Johnson, September 4, 2007: US07265829 (5 worldwide citation)

A reflective light imaging system for use in high-throughput screening of samples disposed in multiple-well plates. The system can include a set of mirrors and lenses. The first mirror has a central aperture through which light from the object passes. The first mirror has a concave reflective surfac ...


8
Douglas N Modlin, Todd E French, Jon F Petersen, John C Owicki: Methods and apparatus for detecting polynucleotide hybridization. LJL BioSystems, Kolisch Hartwell Dickinson McCormack & Heuser, January 7, 2003: US06503719 (4 worldwide citation)

Methods and apparatus for detecting polynucleotide hybridization in luminescence-based assays. The methods may include (1) contacting a sample polynucleotide with a reference polynucleotide at an assay site, where at least one of the polynucleotides is capable of emitting luminescence, (2) illuminat ...


9
Joseph H Jackson, Robert M Gavin III, Richard C Tighe, Steve McNerney, Wu Jiang, Todd E French, Reginald Tobias: Instrument excitation source and calibration method. Molecular Devices, Morgan Lewis & Bockius, May 11, 2010: US07714301 (3 worldwide citation)

An apparatus including an LED excitation source and module useful for full plate imaging fluorescence instruments as well as methods for calibrating such instruments. The apparatus may include a light source operative to provide simultaneous illumination of a first wavelength selected to a plurality ...


10
Todd E French, John C Owicki, Douglas N Modlin: Apparatus and methods for time-resolved optical spectroscopy. Kolisch Hartwell Dickinson Mccormack & Heuser, October 31, 2002: US20020158212-A1 (1 worldwide citation)

Frequency-domain light detection systems and components and uses thereof for performing time-resolved luminescence assays. The systems may include methods for identifying and/or correcting for background and/or quenching, among others. The systems also may include apparatus for increasing duty cycle ...