1
Philip Leder, Timothy A Stewart: Transgenic non-human mammals. President and Fellows of Harvard College, Paul T Clark, April 12, 1988: US04736866 (420 worldwide citation)

A transgenic non-human eukaryotic animal whose germ cells and somatic cells contain an activated oncogene sequence introduced into the animal, or an ancestor of the animal, at an embryonic stage.


2
Philip Leder, Timothy A Stewart: Method for providing a cell culture from a transgenic non-human mammal. President and Fellows of Harvard College, Fish & Richardson, February 11, 1992: US05087571 (43 worldwide citation)

A transgenic non-human eukaryotic animal whose germ cells and somatic cells contain an activated oncogene sequence introduced into the animal, or an ancestor of the animal, at an embryonic stage.


3
Avi Ashkenazi, David Botstein, Luc Desnoyers, Dan L Eaton, Napoleone Ferrara, Ellen Filvaroff, Sherman Fong, Wei Qiang Gao, Hanspeter Gerber, Mary E Gerritsen, Audrey Goddard, Paul J Godowski, J Christopher Grimaldi, Austin L Gurney, Kenneth J Hillan, Ivar J Kljavin, Jennie P Mather, James Pan, Nicholas F Paoni, Margaret Ann Roy, Timothy A Stewart, Daniel Tumas, P Mickey Williams, William I Wood: Secreted and transmembrane polypeptides and nucleic acids encoding the same. Genentech, Elizabeth M Barnes, Mark T Kresnak, Ginger R Greger Esq, October 21, 2003: US06635468 (28 worldwide citation)

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to het ...


4
Kevin P Baker, Luc Desnoyers, Dan L Eaton, Ellen Filvaroff, Wei Qiang Gao, Mary E Gerritsen, Audrey Goddard, Paul J Godowski, Austin L Gurney, Kenneth J Hillan, Sophia S Kuo, James Pan, Margaret Ann Roy, Timothy A Stewart, Daniel Tumas, William I Wood: Secreted and transmembrane polypeptides and nucleic acids encoding the same. Genentech, Elizabeth M Barnes, Mark T Kresnak, Ginger R Dreger, April 18, 2006: US07029874 (15 worldwide citation)

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to het ...


5
Avi Ashkenazi, David Botstein, Luc Desnoyers, Dan L Eaton, Napoleone Ferrara, Ellen Filvaroff, Sherman Fong, Wei Qiang Gao, Hanspeter Gerber, Mary E Gerritsen, Audrey Goddard, Paul J Godowski, J Christopher Grimaldi, Austin L Gurney, Kenneth J Hillan, Ivar J Kljavin, Jennie P Mather, James Pan, Nicholas F Paoni, Margaret Ann Roy, Timothy A Stewart, Daniel Tumas, P Mickey Williams, William I Wood: Nucleic acid encoding PRO211 polypeptides. Genentech, Mark T Kresnak, Ginger R Dreger Esq, Heller Ehrman, December 13, 2005: US06974689 (14 worldwide citation)

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to het ...


6
Ira D Goldfine, Andrew Grupe, Betty A Maddux, Steven Spencer, Timothy A Stewart, Denise M Harrison: Antagonists to insulin receptor tyrosine kinase inhibitor. Regents of the University of California The, Pamela J Sherwood, Bozicevic Field & Francis, October 19, 1999: US05968508 (8 worldwide citation)

A method of diagnosing insulin resistance and related disorders is provided. Additionally, methods of treating mammals with insulin resistance and related disorders is provided. The methods employ antagonists to an insulin receptor tyrosine kinase inhibitor protein.


7
Philip Leder, Timothy A Stewart: Testing method using transgenic mice expressing an oncogene. President and Fellows of Havard College, Clark & Elbing, July 20, 1999: US05925803 (7 worldwide citation)

A transgenic non-human eukaryotic animal whose germ cells and somatic cells contain an activated oncogene sequence introduced into the animal, or an ancestor of the animal, at an embryonic stage.


8
Kevin P Baker, David Botstein, Luc Desnoyers, Dan L Eaton, Napoleone Ferrara, Sherman Fong, Wei Qiang Gao, Audrey Goddard, Paul J Godowski, J Christopher Grimaldi, Austin L Gurney, Kenneth J Hillan, James Pan, Nicholas F Paoni, Margaret Ann Roy, Victoria Smith, Timothy A Stewart, Daniel Tumas, Colin K Watanabe, P Mickey Williams, William I Wood: Secreted and transmembrane polypeptides and nucleic acids encoding the same. Genentech, Elizabeth M Barnes, Mark T Kresnak, Ginger R Dreger, August 30, 2005: US06936436 (7 worldwide citation)

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to het ...


9
Avi Ashkenazi, David Botstein, Luc Desnoyers, Dan L Eaton, Napoleone Ferrara, Ellen Filvaroff, Sherman Fong, Wei Qiang Gao, Hanspeter Gerber, Mary E Gerritsen, Audrey Goddard, Paul J Godowski, J Christopher Grimaldi, Austin Gurney, Kenneth J Hillan, Ivar J Kljavin, Jenni P Mather, James Pan, Nicholas F Paoni, Margaret Ann Roy, Timothy A Stewart, Daniel Tumas, P Mickey Williams, William I Wood: Secreted and transmembrane polypeptides nucleic acid encoding. Genetech, Mark T Kresnak, Elizabeth M Barnes, Ginger R Dreger Esq, July 11, 2006: US07074592 (7 worldwide citation)

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to het ...


10
Ira D Goldfine, Andrew Grupe, Betty A Maddux, Steven Spencer, Timothy A Stewart: Antagonists to insulin receptor tyrosine kinase inhibitor. The Regents Of The University Of California, Genentech, Pamela Sherwood, Bozicevic Field & Francis, August 17, 1999: US05939269 (6 worldwide citation)

A method of diagnosing insulin resistance and related disorders is provided. Additionally, methods of treating animals with insulin resistance and related disorders if provided. The methods employ antagonists to an insulin receptor tyrosine kinase inhibitor protein.