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Tianbao Lu, Bruce E Tomczuk, Thomas P Markotan, Colleen Siedem: Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors. 3 Dimensional Pharmaceuticals, Sterne Kessler Goldstein & Fox P L L C, March 14, 2000: US06037356 (22 worldwide citation)

Aminoguanidine and alkoxyguanidine compounds are described, including compounds of the Formula VII: ##STR1## wherein X is O or NR.sup.9 and Het, R.sup.1, R.sup.7, R.sup.8, R.sup.12 -R.sup.15, R.sup.a, R.sup.b, R.sup.c, Z, and n are set forth in the specification, as well as hydrates, solvates or pha ...


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Carl R Illig, Richard M Soll, Joseph M Salvino, Bruce E Tomczuk, Tianbao Lu, Nalin L Subasinghe: Arylsulfonylaminobenzene derivatives and the use thereof as factor Xa inhibitors. 3 Dimensional Pharmaceuticals, Sterne Kessler Goldstein & Fox P L L C, April 21, 1998: US05741819 (15 worldwide citation)

The present invention is directed to non-peptidic factor Xa inhibitors which are useful for the treatment of arterial and venous thrombotic occlusive disorders, inflammation, cancer, and neurodegenerative diseases. The factor Xa inhibitors provide compounds of structure: ##STR1## or pharmaceutically ...


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Richard M Soll, Tianbao Lu, Cynthia L Fedde, Bruce E Tomczuk, Carl Illig: Amidinohydrazones as protease inhibitors. 3 Dimensional Pharmaceuticals, Sterne Kessler Goldstein & Fox P L L C, April 6, 1999: US05891909 (13 worldwide citation)

Amidino and benzamidino compounds, including compounds of the formula: ##STR1## wherein R.sup.1 -R.sup.4, R.sup.6 -R.sup.9, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin ...


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Tianbao Lu, Carl R Illig, Bruce E Tomczuk, Richard M Soll, Nalin L Subasinghe, Roger F Bone: Guanidino protease inhibitors. 3 Dimensional Pharmaceuticals, Sterne Kessler Goldstein & Fox P L L C, August 11, 1998: US05792769 (12 worldwide citation)

Compounds of the formula: ##STR1## wherein R.sup.1 --R.sup.4, R.sup.7 --R.sup.8, R.sup.a, R.sup.b, R.sup.c, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit a number of proteolytic enzymes are described. Also d ...


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Roger F Bone, Richard M Soll, Carl L Illig, Tianbao Lu, Nalin L Subasinghe: Thrombin inhibitors. 3 Dimensional Pharmaceuticals, Sterne Kessler Goldstein Fox P L L C, March 18, 1997: US05612369 (10 worldwide citation)

The present invention is directed to novel compounds that are thrombin inhibitors and are useful for the treatment of arterial and venous thrombotic occlusive disorders, inflammation, cancer, and neurodegenerative diseases. The compounds have the general Formula I: ##STR1## and pharmaceutically acce ...


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Wenxi Pan, Tianbao Lu, Thomas P Markotan, Bruce E Tomczuk: Aminopyridyl-substituted phenyl acetamides as protease inhibitors. 3 Dimensional Pharmaceuticals, Woodcock Washburn, May 31, 2005: US06900231 (7 worldwide citation)

Phenyl acetamide compounds are described, including compounds of or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R3-R6, R11, B, Y and W are set forth in the specification. The compounds of the invention are potent inhibitors of proteases, especially trypsin-like serine pro ...


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