1
Thorsteinn Loftsson: Cyclodextrin/drug complexation. Burns Doane Swecker & Mathis, June 28, 1994: US05324718 (75 worldwide citation)

The invention provides a method for enhancing the complexation of a cyclodextrin with a lipophilic and/or water-libile drug, comprising combining from about 0.1 to about 70% (weight/volume) of a cyclodextrin and from about 0.01 to about 5% (weight/volume) of a pharmaceutically acceptable, pharmacolo ...


2
Thorsteinn Loftsson: Cyclodextrin complexation. Cyclops h f, Burns Doane Swecker & Mathis, December 5, 1995: US05472954 (73 worldwide citation)

The invention provides a method for enhancing the complexation of a cyclodextrin with a lipophilic and/or water-labile active ingredient which is a drug, cosmetic additive, food additive or agrochemical, comprising combining from about 0.1 to about 70% (weight/volume) of a cyclodextrin, from about 0 ...


3
Nicholas Bodor, Thorsteinn Loftsson: Percutaneous penetration enhancer of oleic acid and 2-ethyl-1, 3-hexanediol. Key Pharmaceuticals, John J Maitner, Stephen I Miller, James R Nelson, August 16, 1988: US04764381 (37 worldwide citation)

Pharmaceutical preparations comprised of a pharmaceutically active ingredient and a carrier which comprises a percutaneous penetration enhancer comprised of 2-ethyl-1, 3-hexanediol alone or in combination with oleic acid is disclosed. The 2-ethyl-1, 3-hexanediol may be present in an amount in the ra ...


4
Thorsteinn Loftsson, Nicholas Bodor: Sulfur-substituted phenylacetamides. Key Pharmaceuticals, Anita W Magatti, Stephen I Miller, August 22, 1989: US04859707 (20 worldwide citation)

This invention relates to sulfur-substituted phenylacetamides of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 may be the same or different and are H or CH.sub.3 ; R.sub.4 is SR.sub.5, ##STR2## R.sub.5 and R.sub.6 may be the same or different and are lower alkyl containing 1-4 carbon ato ...


5
Thorsteinn Loftsson, Einar Stefánsson: Cyclodextrin nanotechnology for ophthalmic drug delivery. Oculis ehf, Buchanan Ingersoll & Rooney PC, February 22, 2011: US07893040 (14 worldwide citation)

The invention provides an ophthalmic composition which is an aqueous suspension comprising drug, cyclodextrin and water, the composition having an aqueous phase of from about 0.1% (w/v) to about 90% (w/v) of the drug in solution, as dissolved free drug and as dissolved drug/cyclodextrin complex(es), ...


6
Thorsteinn Loftsson, Mar Masson, Einar Stefansson: Cyclodextrin complexes of benzodiazepines. Cyclops ehf, Burns Doane Swecker & Mathis L, March 2, 2004: US06699849 (13 worldwide citation)

Methods for enhancing the complexation efficiency of a drug with cyclodextrin and for enhancing the availability of a drug following administration of a cyclodextrin-drug complex.


7
Nicholas Bodor, Thorsteinn Loftsson: Percutaneous penetration enhancer of oleic acid and 2-ethyl-1,3-hexanediol. Key Pharmaceuticals, John J Maitner, Stephen I Miller, James R Nelson, December 5, 1989: US04885174 (12 worldwide citation)

Pharmaceutical preparations comprised of a pharmaceutically active ingredient and a carrier which comprises a percutaneous penetration enhancer comprised of 2-ethyl-1, 3-hexanediol alone or in combination with oleic acid is disclosed. The 2-ethyl-1, 3-hexanediol may be present in an amount in the ra ...


8
Nicholas S Bodor, Thorsteinn Loftsson: Composition and method for enhancing permeability of topical drugs. University of Florida, Dennis P Clarke, January 9, 1990: US04892737 (12 worldwide citation)

A composition and method for enhancing permeability of topical drugs wherein the agent which enhances the permeability of the drug is selected from the group consisting of (1) a choline ester having the formula:


9
Thorsteinn Loftsson: Non-inclusion cyclodextrin complexes. Decode Genetics EHF, Buchanan Ingersoll & Rooney PC, October 3, 2006: US07115586 (11 worldwide citation)

The invention provides a number of methods for enhancing the aqueous solubility of an active ingredient which is insoluble or sparingly soluble in water. In one preferred embodiment, solubilization of the active ingredient is enhanced by combining it with ╬▓-cyclodextrin in an aqueous complexation me ...


10
Nicholas Bodor, Thorsteinn Loftsson: Percutaneous penetration enhancer of oleic acid and 2-ethyl-1,3-hexanediol. Key Pharmaceuticals, John J Maitner, Stephen I Miller, James R Nelson, January 8, 1991: US04983396 (7 worldwide citation)

Pharmaceutical preparations comprised of a pharmaceutically active ingredient and a carrier which comprises a percutaneous penetration enhancer comprised of 2-ethyl-1, 3-hexanediol alone or in combination with oleic acid is disclosed. The 2-ethyl-1, 3-hexanediol may be present in an amount in the ra ...



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